Hematopoietic stem cells and their niche

Toshio Suda, Fumio Arai, Atsushi Hirao

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Recent evidence indicates that osteoblasts are crucial components of the particular microenvironments, or niches, for hematopoietic stem cells (HSCs) in adult bone marrow (BM). Stem cells persist in an immature state within the BM. The quiescence of HSCs is controlled dynamically by the signaling of receptors-ligands and cell-adhesion molecules. In this review, the characteristics of HSCs in the niche are discussed. The understanding of the relationship between normal and cancer stem cells and their niches should lead to the development of new strategies directed toward regeneration medicine and cancer therapeutics.

Original languageEnglish
Pages (from-to)426-433
Number of pages8
JournalTrends in Immunology
Volume26
Issue number8
DOIs
Publication statusPublished - 2005 Aug

Fingerprint

Stem Cell Niche
Hematopoietic Stem Cells
Bone Marrow
Neoplastic Stem Cells
Cell Adhesion Molecules
Osteoblasts
Regeneration
Stem Cells
Medicine
Ligands
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Hematopoietic stem cells and their niche. / Suda, Toshio; Arai, Fumio; Hirao, Atsushi.

In: Trends in Immunology, Vol. 26, No. 8, 08.2005, p. 426-433.

Research output: Contribution to journalArticle

Suda, T, Arai, F & Hirao, A 2005, 'Hematopoietic stem cells and their niche', Trends in Immunology, vol. 26, no. 8, pp. 426-433. https://doi.org/10.1016/j.it.2005.06.006
Suda, Toshio ; Arai, Fumio ; Hirao, Atsushi. / Hematopoietic stem cells and their niche. In: Trends in Immunology. 2005 ; Vol. 26, No. 8. pp. 426-433.
@article{2b9eb9e085734dc3bd77f14cf3c19b3e,
title = "Hematopoietic stem cells and their niche",
abstract = "Recent evidence indicates that osteoblasts are crucial components of the particular microenvironments, or niches, for hematopoietic stem cells (HSCs) in adult bone marrow (BM). Stem cells persist in an immature state within the BM. The quiescence of HSCs is controlled dynamically by the signaling of receptors-ligands and cell-adhesion molecules. In this review, the characteristics of HSCs in the niche are discussed. The understanding of the relationship between normal and cancer stem cells and their niches should lead to the development of new strategies directed toward regeneration medicine and cancer therapeutics.",
author = "Toshio Suda and Fumio Arai and Atsushi Hirao",
year = "2005",
month = "8",
doi = "10.1016/j.it.2005.06.006",
language = "English",
volume = "26",
pages = "426--433",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Limited",
number = "8",

}

TY - JOUR

T1 - Hematopoietic stem cells and their niche

AU - Suda, Toshio

AU - Arai, Fumio

AU - Hirao, Atsushi

PY - 2005/8

Y1 - 2005/8

N2 - Recent evidence indicates that osteoblasts are crucial components of the particular microenvironments, or niches, for hematopoietic stem cells (HSCs) in adult bone marrow (BM). Stem cells persist in an immature state within the BM. The quiescence of HSCs is controlled dynamically by the signaling of receptors-ligands and cell-adhesion molecules. In this review, the characteristics of HSCs in the niche are discussed. The understanding of the relationship between normal and cancer stem cells and their niches should lead to the development of new strategies directed toward regeneration medicine and cancer therapeutics.

AB - Recent evidence indicates that osteoblasts are crucial components of the particular microenvironments, or niches, for hematopoietic stem cells (HSCs) in adult bone marrow (BM). Stem cells persist in an immature state within the BM. The quiescence of HSCs is controlled dynamically by the signaling of receptors-ligands and cell-adhesion molecules. In this review, the characteristics of HSCs in the niche are discussed. The understanding of the relationship between normal and cancer stem cells and their niches should lead to the development of new strategies directed toward regeneration medicine and cancer therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=22444447491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22444447491&partnerID=8YFLogxK

U2 - 10.1016/j.it.2005.06.006

DO - 10.1016/j.it.2005.06.006

M3 - Article

VL - 26

SP - 426

EP - 433

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 8

ER -