Hemobilia due to biliary intraepithelial neoplasia associated with Zollinger-Ellison syndrome

Rumiko Umeda, Yuji Nakamura, Yohei Masugi, Masahiro Shinoda, Naoki Hosoe, Yoshihiro Ono, Tomonori Fujimura, Yoshiyuki Yamagishi, Hajime Higuchi, Hirotoshi Ebinuma, Shigenari Hozawa, Minoru Tanabe, Subaru Hashimoto, Michiie Sakamoto, Yuukou Kitagawa, Toshifumi Hibi

Research output: Contribution to journalArticle

Abstract

A 58-year-old man was transferred to us from his local hospital because of failure to control his gastrointestinal bleeding by endoscopic hemostasis. Abdominal imaging suggested a hypervascular tumor of the pancreatic head (36 mm diameter), and laboratory testing showed an elevated serum gastrin level (17,800 pg/mL). Gastroduodenal endoscopy revealed multiple duodenal ulcers and active bleeding from the ampulla of Vater. The selective arterial secretagogue injection test suggested a gastrinoma in the pancreatic head, but no gastrinoma in the pancreatic tail. The patient was diagnosed with solitary pancreatic head gastrinoma complicated by hemosuccus pancreaticus, and pancreaticoduodenectomy was performed. Intraoperatively, the diagnosis was changed to primary peripancreatic lymph node gastrinoma without pancreatic involvement. The gastrointestinal bleeding stopped postoperatively and serum gastrin levels returned to normal. Histological examination of the surgical specimens revealed a small submucosal gastrinoma in the duodenum (7 mm diameter). The final diagnosis was microgastrinoma of the duodenum with peripancreatic lymph node metastasis. The cause of bleeding from the ampulla of Vater was initially obscure, but eventually a hemorrhagic erosion with moderate atypia was found in the common bile duct, indicating biliary intraepithelial neoplasia (BilIN). This is the first report of hemobilia due to BilIN with gastrinoma.

Original languageEnglish
Pages (from-to)189-194
Number of pages6
JournalClinical Journal of Gastroenterology
Volume5
Issue number3
DOIs
Publication statusPublished - 2012 Jun

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Hemobilia
Gastrinoma
Zollinger-Ellison Syndrome
Hemorrhage
Ampulla of Vater
Neoplasms
Duodenum
Lymph Nodes
Endoscopic Hemostasis
Pancreaticoduodenectomy
Gastrins
Common Bile Duct
Duodenal Ulcer
Serum
Endoscopy
Neoplasm Metastasis
Injections

Keywords

  • Biliary intraepithelial neoplasia
  • Gastrinoma
  • GI bleeding
  • Hemobilia
  • Zollinger-Ellison syndrome

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hemobilia due to biliary intraepithelial neoplasia associated with Zollinger-Ellison syndrome. / Umeda, Rumiko; Nakamura, Yuji; Masugi, Yohei; Shinoda, Masahiro; Hosoe, Naoki; Ono, Yoshihiro; Fujimura, Tomonori; Yamagishi, Yoshiyuki; Higuchi, Hajime; Ebinuma, Hirotoshi; Hozawa, Shigenari; Tanabe, Minoru; Hashimoto, Subaru; Sakamoto, Michiie; Kitagawa, Yuukou; Hibi, Toshifumi.

In: Clinical Journal of Gastroenterology, Vol. 5, No. 3, 06.2012, p. 189-194.

Research output: Contribution to journalArticle

Umeda, Rumiko ; Nakamura, Yuji ; Masugi, Yohei ; Shinoda, Masahiro ; Hosoe, Naoki ; Ono, Yoshihiro ; Fujimura, Tomonori ; Yamagishi, Yoshiyuki ; Higuchi, Hajime ; Ebinuma, Hirotoshi ; Hozawa, Shigenari ; Tanabe, Minoru ; Hashimoto, Subaru ; Sakamoto, Michiie ; Kitagawa, Yuukou ; Hibi, Toshifumi. / Hemobilia due to biliary intraepithelial neoplasia associated with Zollinger-Ellison syndrome. In: Clinical Journal of Gastroenterology. 2012 ; Vol. 5, No. 3. pp. 189-194.
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AU - Ono, Yoshihiro

AU - Fujimura, Tomonori

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AU - Tanabe, Minoru

AU - Hashimoto, Subaru

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AU - Hibi, Toshifumi

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