Hemopoietic colony-forming cells in shwachman’s syndrome

Toshio Suda, Koichiro Ikuta, Hideaki Mizoguchi, Hideki Sasaki, Yasusada Miura, Takeshi Nagao, Kazuo Kubota

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Colony-forming capacities were studied in three Japanese children with Shwachman’s syndrome (chronic neu-tropenia and exocrine pancreatic insufficiency). Bone marrow granulocyte-macrophage colony-forming cells assayed in a soft agar culture were markedly reduced in all three cases. The cytochemical examination of granu-locyte-macrophage colonies by a new technique revealed that 90% of the colonies consisted exclusively of granu-locytes. Erythroid colony-forming cells assayed in a plasma clot culture were significantly reduced in two of the three cases. Bone marrow phagocytic cells did not suppress granulopoiesis in contrast to the cases of idio-pathic aplastic anemia. Moreover, the patient serum did not inhibit granulopoiesis of normal bone marrow cells. These results have been discussed with the possibility of involving the hemopoietic stem cells and other additional factors.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume4
Issue number2
Publication statusPublished - 1982

Fingerprint

Bone Marrow Cells
Macrophages
Exocrine Pancreatic Insufficiency
Aplastic Anemia
Phagocytes
Granulocytes
Agar
Stem Cells
Bone Marrow
Serum
Shwachman syndrome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

Suda, T., Ikuta, K., Mizoguchi, H., Sasaki, H., Miura, Y., Nagao, T., & Kubota, K. (1982). Hemopoietic colony-forming cells in shwachman’s syndrome. American Journal of Pediatric Hematology/Oncology, 4(2), 129-133.

Hemopoietic colony-forming cells in shwachman’s syndrome. / Suda, Toshio; Ikuta, Koichiro; Mizoguchi, Hideaki; Sasaki, Hideki; Miura, Yasusada; Nagao, Takeshi; Kubota, Kazuo.

In: American Journal of Pediatric Hematology/Oncology, Vol. 4, No. 2, 1982, p. 129-133.

Research output: Contribution to journalArticle

Suda, T, Ikuta, K, Mizoguchi, H, Sasaki, H, Miura, Y, Nagao, T & Kubota, K 1982, 'Hemopoietic colony-forming cells in shwachman’s syndrome', American Journal of Pediatric Hematology/Oncology, vol. 4, no. 2, pp. 129-133.
Suda T, Ikuta K, Mizoguchi H, Sasaki H, Miura Y, Nagao T et al. Hemopoietic colony-forming cells in shwachman’s syndrome. American Journal of Pediatric Hematology/Oncology. 1982;4(2):129-133.
Suda, Toshio ; Ikuta, Koichiro ; Mizoguchi, Hideaki ; Sasaki, Hideki ; Miura, Yasusada ; Nagao, Takeshi ; Kubota, Kazuo. / Hemopoietic colony-forming cells in shwachman’s syndrome. In: American Journal of Pediatric Hematology/Oncology. 1982 ; Vol. 4, No. 2. pp. 129-133.
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