Hepatocellular carcinoma in heavy drinkers with negative markers for viral hepatitis

Yoshiyuki Yamagishi, Yoshinori Horie, Mikio Kajihara, Masahiro Konishi, Hirotoshi Ebinuma, Hidetsugu Saito, Shinzo Kato, Akira Yokoyama, Katsuya Maruyama, Hiromasa Ishii

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Alcohol has been known to be associated with an increased risk of cancer. We investigated the characteristics of hepatocellular carcinoma (HCC) in heavy drinkers with negative serum markers for viral hepatitis (non-B, non-C) to determine whether ethanol enhances the development of HCC in Japanese patients with or without serum markers for viral hepatitis. Among the 432 HCC cases seen at our hospital between 1995 and 2000, 26 patients had negative serum markers (non-B, non-C) and were heavy drinkers. The mean patient age at the time of HCC diagnosis was 64.2±7.6 years. The mean total ethanol intake was 1617±796kg. Most of the patients also had liver cirrhosis (LC), although the frequency was significantly higher in non-B, non-C, heavy drinkers HCC cases than in non-B, non-C, non-alcoholic HCC cases. Among the hepatitis C virus (HCV)-positive cases, the mean age at the time of HCC diagnosis was lower in heavy drinkers; this trend was not seen in HBV-positive cases. In HCC cases with heavy drinking, a high frequency of gastrointestinal (oropharynx, esophagus, stomach, colon and anal) cancers was seen. As for the aldehyde dehydrogenase-2 (ALDH2) genotype, the frequency of normal homozygotes was 87.5% in heavy drinkers with HCC and the frequency of heterozygotes was 12.5%; the frequency of heterozygotes was 58.3% in alcoholics with esophageal cancer. More than half of the non-B, non-C, heavy drinkers HCC cases had a normal range of serum alpha-fetoprotein (AFP) levels. These results indicate that heavy drinking enhances HCV-related hepatocarcinogenesis. Whether or not ethanol is directly involved in hepatocarcinogenesis remains controversial, but LC may progress HCC in heavy drinkers even if their serum markers for HBV (including tissue) or HCV are negative. Therefore, close observation, including radiographic examinations, is recommended for non-B, non-C, heavy drinkers with LC. In HCV-positive cases, abstinence or a reduction in daily ethanol intake is recommended.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalHepatology Research
Volume28
Issue number4
DOIs
Publication statusPublished - 2004 Apr

Fingerprint

Hepatitis
Hepatocellular Carcinoma
Biomarkers
Hepacivirus
Ethanol
Liver Cirrhosis
Heterozygote
Drinking
Anus Neoplasms
Aldehyde Dehydrogenase
Oropharynx
Homozygote
alpha-Fetoproteins
Alcoholics
Esophageal Neoplasms
Hepatitis B
Colonic Neoplasms
Esophagus
Stomach
Reference Values

Keywords

  • Alcohol
  • Alcoholic liver disease (ALD)
  • Aldehyde dehydrogenase-2 (ALDH2)
  • Hepatocellular carcinoma (HCC)

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Yamagishi, Y., Horie, Y., Kajihara, M., Konishi, M., Ebinuma, H., Saito, H., ... Ishii, H. (2004). Hepatocellular carcinoma in heavy drinkers with negative markers for viral hepatitis. Hepatology Research, 28(4), 177-183. https://doi.org/10.1016/j.hepres.2003.11.009

Hepatocellular carcinoma in heavy drinkers with negative markers for viral hepatitis. / Yamagishi, Yoshiyuki; Horie, Yoshinori; Kajihara, Mikio; Konishi, Masahiro; Ebinuma, Hirotoshi; Saito, Hidetsugu; Kato, Shinzo; Yokoyama, Akira; Maruyama, Katsuya; Ishii, Hiromasa.

In: Hepatology Research, Vol. 28, No. 4, 04.2004, p. 177-183.

Research output: Contribution to journalArticle

Yamagishi, Y, Horie, Y, Kajihara, M, Konishi, M, Ebinuma, H, Saito, H, Kato, S, Yokoyama, A, Maruyama, K & Ishii, H 2004, 'Hepatocellular carcinoma in heavy drinkers with negative markers for viral hepatitis', Hepatology Research, vol. 28, no. 4, pp. 177-183. https://doi.org/10.1016/j.hepres.2003.11.009
Yamagishi, Yoshiyuki ; Horie, Yoshinori ; Kajihara, Mikio ; Konishi, Masahiro ; Ebinuma, Hirotoshi ; Saito, Hidetsugu ; Kato, Shinzo ; Yokoyama, Akira ; Maruyama, Katsuya ; Ishii, Hiromasa. / Hepatocellular carcinoma in heavy drinkers with negative markers for viral hepatitis. In: Hepatology Research. 2004 ; Vol. 28, No. 4. pp. 177-183.
@article{f93a5b9d2df64219becbe5c800225af2,
title = "Hepatocellular carcinoma in heavy drinkers with negative markers for viral hepatitis",
abstract = "Alcohol has been known to be associated with an increased risk of cancer. We investigated the characteristics of hepatocellular carcinoma (HCC) in heavy drinkers with negative serum markers for viral hepatitis (non-B, non-C) to determine whether ethanol enhances the development of HCC in Japanese patients with or without serum markers for viral hepatitis. Among the 432 HCC cases seen at our hospital between 1995 and 2000, 26 patients had negative serum markers (non-B, non-C) and were heavy drinkers. The mean patient age at the time of HCC diagnosis was 64.2±7.6 years. The mean total ethanol intake was 1617±796kg. Most of the patients also had liver cirrhosis (LC), although the frequency was significantly higher in non-B, non-C, heavy drinkers HCC cases than in non-B, non-C, non-alcoholic HCC cases. Among the hepatitis C virus (HCV)-positive cases, the mean age at the time of HCC diagnosis was lower in heavy drinkers; this trend was not seen in HBV-positive cases. In HCC cases with heavy drinking, a high frequency of gastrointestinal (oropharynx, esophagus, stomach, colon and anal) cancers was seen. As for the aldehyde dehydrogenase-2 (ALDH2) genotype, the frequency of normal homozygotes was 87.5{\%} in heavy drinkers with HCC and the frequency of heterozygotes was 12.5{\%}; the frequency of heterozygotes was 58.3{\%} in alcoholics with esophageal cancer. More than half of the non-B, non-C, heavy drinkers HCC cases had a normal range of serum alpha-fetoprotein (AFP) levels. These results indicate that heavy drinking enhances HCV-related hepatocarcinogenesis. Whether or not ethanol is directly involved in hepatocarcinogenesis remains controversial, but LC may progress HCC in heavy drinkers even if their serum markers for HBV (including tissue) or HCV are negative. Therefore, close observation, including radiographic examinations, is recommended for non-B, non-C, heavy drinkers with LC. In HCV-positive cases, abstinence or a reduction in daily ethanol intake is recommended.",
keywords = "Alcohol, Alcoholic liver disease (ALD), Aldehyde dehydrogenase-2 (ALDH2), Hepatocellular carcinoma (HCC)",
author = "Yoshiyuki Yamagishi and Yoshinori Horie and Mikio Kajihara and Masahiro Konishi and Hirotoshi Ebinuma and Hidetsugu Saito and Shinzo Kato and Akira Yokoyama and Katsuya Maruyama and Hiromasa Ishii",
year = "2004",
month = "4",
doi = "10.1016/j.hepres.2003.11.009",
language = "English",
volume = "28",
pages = "177--183",
journal = "Hepatology Research",
issn = "1386-6346",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "4",

}

TY - JOUR

T1 - Hepatocellular carcinoma in heavy drinkers with negative markers for viral hepatitis

AU - Yamagishi, Yoshiyuki

AU - Horie, Yoshinori

AU - Kajihara, Mikio

AU - Konishi, Masahiro

AU - Ebinuma, Hirotoshi

AU - Saito, Hidetsugu

AU - Kato, Shinzo

AU - Yokoyama, Akira

AU - Maruyama, Katsuya

AU - Ishii, Hiromasa

PY - 2004/4

Y1 - 2004/4

N2 - Alcohol has been known to be associated with an increased risk of cancer. We investigated the characteristics of hepatocellular carcinoma (HCC) in heavy drinkers with negative serum markers for viral hepatitis (non-B, non-C) to determine whether ethanol enhances the development of HCC in Japanese patients with or without serum markers for viral hepatitis. Among the 432 HCC cases seen at our hospital between 1995 and 2000, 26 patients had negative serum markers (non-B, non-C) and were heavy drinkers. The mean patient age at the time of HCC diagnosis was 64.2±7.6 years. The mean total ethanol intake was 1617±796kg. Most of the patients also had liver cirrhosis (LC), although the frequency was significantly higher in non-B, non-C, heavy drinkers HCC cases than in non-B, non-C, non-alcoholic HCC cases. Among the hepatitis C virus (HCV)-positive cases, the mean age at the time of HCC diagnosis was lower in heavy drinkers; this trend was not seen in HBV-positive cases. In HCC cases with heavy drinking, a high frequency of gastrointestinal (oropharynx, esophagus, stomach, colon and anal) cancers was seen. As for the aldehyde dehydrogenase-2 (ALDH2) genotype, the frequency of normal homozygotes was 87.5% in heavy drinkers with HCC and the frequency of heterozygotes was 12.5%; the frequency of heterozygotes was 58.3% in alcoholics with esophageal cancer. More than half of the non-B, non-C, heavy drinkers HCC cases had a normal range of serum alpha-fetoprotein (AFP) levels. These results indicate that heavy drinking enhances HCV-related hepatocarcinogenesis. Whether or not ethanol is directly involved in hepatocarcinogenesis remains controversial, but LC may progress HCC in heavy drinkers even if their serum markers for HBV (including tissue) or HCV are negative. Therefore, close observation, including radiographic examinations, is recommended for non-B, non-C, heavy drinkers with LC. In HCV-positive cases, abstinence or a reduction in daily ethanol intake is recommended.

AB - Alcohol has been known to be associated with an increased risk of cancer. We investigated the characteristics of hepatocellular carcinoma (HCC) in heavy drinkers with negative serum markers for viral hepatitis (non-B, non-C) to determine whether ethanol enhances the development of HCC in Japanese patients with or without serum markers for viral hepatitis. Among the 432 HCC cases seen at our hospital between 1995 and 2000, 26 patients had negative serum markers (non-B, non-C) and were heavy drinkers. The mean patient age at the time of HCC diagnosis was 64.2±7.6 years. The mean total ethanol intake was 1617±796kg. Most of the patients also had liver cirrhosis (LC), although the frequency was significantly higher in non-B, non-C, heavy drinkers HCC cases than in non-B, non-C, non-alcoholic HCC cases. Among the hepatitis C virus (HCV)-positive cases, the mean age at the time of HCC diagnosis was lower in heavy drinkers; this trend was not seen in HBV-positive cases. In HCC cases with heavy drinking, a high frequency of gastrointestinal (oropharynx, esophagus, stomach, colon and anal) cancers was seen. As for the aldehyde dehydrogenase-2 (ALDH2) genotype, the frequency of normal homozygotes was 87.5% in heavy drinkers with HCC and the frequency of heterozygotes was 12.5%; the frequency of heterozygotes was 58.3% in alcoholics with esophageal cancer. More than half of the non-B, non-C, heavy drinkers HCC cases had a normal range of serum alpha-fetoprotein (AFP) levels. These results indicate that heavy drinking enhances HCV-related hepatocarcinogenesis. Whether or not ethanol is directly involved in hepatocarcinogenesis remains controversial, but LC may progress HCC in heavy drinkers even if their serum markers for HBV (including tissue) or HCV are negative. Therefore, close observation, including radiographic examinations, is recommended for non-B, non-C, heavy drinkers with LC. In HCV-positive cases, abstinence or a reduction in daily ethanol intake is recommended.

KW - Alcohol

KW - Alcoholic liver disease (ALD)

KW - Aldehyde dehydrogenase-2 (ALDH2)

KW - Hepatocellular carcinoma (HCC)

UR - http://www.scopus.com/inward/record.url?scp=12144290253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12144290253&partnerID=8YFLogxK

U2 - 10.1016/j.hepres.2003.11.009

DO - 10.1016/j.hepres.2003.11.009

M3 - Article

AN - SCOPUS:12144290253

VL - 28

SP - 177

EP - 183

JO - Hepatology Research

JF - Hepatology Research

SN - 1386-6346

IS - 4

ER -