Hepatoid adenocarcinoma of the stomach with multi-nucleated giant cell proliferation in a 100-year-old man

Kazuhiro Yamanoi, Yasuko Kondoh, Taku Fujii, Naoto Kurihara, Makio Mukai, Michiie Sakamoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Few cases of gastric carcinoma with infiltrating multi-nucleated giant cells (MGCs) have been reported, and giant cells infiltrating the gastric carcinoma were previously described as osteoclast-like giant cells (OGCs). However, hepatoid adenocarcinomas have never been reported previously, and the present case is extremely rare. A 100-year-old Japanese man with gastralgia was found to have a mass in his gastric body. Histological examination showed a poorly differentiated adenocarcinoma with infiltration of MGCs. Vascular and lymphatic invasion were noted but there were no metastases. Almost all the tumor comprised cells with hepatoid-like features. The MGCs proliferated, with infiltration of lymphoid cells. A few MGCs contained mucous material in their cytoplasm, indicating these were foreign-body giant cells. Immunohistochemically, the hepatoid-like components were positive for AFP, and staining with polyclonal antibodies against carcinoembryonic antigen (CEA) showed the canalicular pattern. We concluded that this component was hepatoid adenocarcinoma. The MGCs were positive for CD68, and surrounding infiltrating lymphoid cells were diffusely positive for CD3. Infiltration of MGCs in gastric cancer may represent a cellular immune response against gastric cancer invasion. Further studies are required to elucidate the etiology of MGCs in gastric cancer.

Original languageEnglish
Pages (from-to)750-754
Number of pages5
JournalPathology International
Volume60
Issue number11
DOIs
Publication statusPublished - 2010 Nov

Fingerprint

Giant Cells
Stomach
Adenocarcinoma
Cell Proliferation
Stomach Neoplasms
Foreign Body Giant Cells
Lymphocytes
Carcinoma
Carcinoembryonic Antigen
Osteoclasts
Cellular Immunity
Blood Vessels
Cytoplasm
Staining and Labeling
Neoplasm Metastasis
Antibodies

Keywords

  • α-fetoprotein
  • Gastric carcinoma
  • Giant cell
  • Hepatoid
  • Osteoclast-like
  • Stomach

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Hepatoid adenocarcinoma of the stomach with multi-nucleated giant cell proliferation in a 100-year-old man. / Yamanoi, Kazuhiro; Kondoh, Yasuko; Fujii, Taku; Kurihara, Naoto; Mukai, Makio; Sakamoto, Michiie.

In: Pathology International, Vol. 60, No. 11, 11.2010, p. 750-754.

Research output: Contribution to journalArticle

Yamanoi, Kazuhiro ; Kondoh, Yasuko ; Fujii, Taku ; Kurihara, Naoto ; Mukai, Makio ; Sakamoto, Michiie. / Hepatoid adenocarcinoma of the stomach with multi-nucleated giant cell proliferation in a 100-year-old man. In: Pathology International. 2010 ; Vol. 60, No. 11. pp. 750-754.
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