Hepatoprotective activity of phenylethanoids from Cistanche deserticola

Quanbo Xiong, Koji Hase, Yasuhiro Tezuka, Tadato Tani, Tsuneo Namba, Shigetoshi Kadota

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D- GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.

Original languageEnglish
Pages (from-to)120-125
Number of pages6
JournalPlanta Medica
Volume64
Issue number2
Publication statusPublished - 1998 Apr 16
Externally publishedYes

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Keywords

  • Carbon tetrachloride
  • Cistanche deserticola
  • D-galactosamine
  • Hepatoprotective activity
  • Orobanchaceae
  • Phenylethanoids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Xiong, Q., Hase, K., Tezuka, Y., Tani, T., Namba, T., & Kadota, S. (1998). Hepatoprotective activity of phenylethanoids from Cistanche deserticola. Planta Medica, 64(2), 120-125.