Hepatoprotective activity of phenylethanoids from Cistanche deserticola

Quanbo Xiong, Kouji Hase, Yasuhiro Tezuka, Tadato Tani, Tsuneo Namba, Shigetoshi Kadota

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D- GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.

Original languageEnglish
Pages (from-to)120-125
Number of pages6
JournalPlanta Medica
Volume64
Issue number2
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Cistanche
hepatoprotective effect
Rats
galactosamine
Galactosamine
liver microsomes
rats
Liver Microsomes
NADP
NADP (coenzyme)
Liver
Lipid Peroxidation
hepatocytes
Hepatocytes
lipid peroxidation
Cells
Lipids
stems
cells
Cistanche deserticola

Keywords

  • Carbon tetrachloride
  • Cistanche deserticola
  • D-galactosamine
  • Hepatoprotective activity
  • Orobanchaceae
  • Phenylethanoids

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Xiong, Q., Hase, K., Tezuka, Y., Tani, T., Namba, T., & Kadota, S. (1998). Hepatoprotective activity of phenylethanoids from Cistanche deserticola. Planta Medica, 64(2), 120-125.

Hepatoprotective activity of phenylethanoids from Cistanche deserticola. / Xiong, Quanbo; Hase, Kouji; Tezuka, Yasuhiro; Tani, Tadato; Namba, Tsuneo; Kadota, Shigetoshi.

In: Planta Medica, Vol. 64, No. 2, 1998, p. 120-125.

Research output: Contribution to journalArticle

Xiong, Q, Hase, K, Tezuka, Y, Tani, T, Namba, T & Kadota, S 1998, 'Hepatoprotective activity of phenylethanoids from Cistanche deserticola', Planta Medica, vol. 64, no. 2, pp. 120-125.
Xiong Q, Hase K, Tezuka Y, Tani T, Namba T, Kadota S. Hepatoprotective activity of phenylethanoids from Cistanche deserticola. Planta Medica. 1998;64(2):120-125.
Xiong, Quanbo ; Hase, Kouji ; Tezuka, Yasuhiro ; Tani, Tadato ; Namba, Tsuneo ; Kadota, Shigetoshi. / Hepatoprotective activity of phenylethanoids from Cistanche deserticola. In: Planta Medica. 1998 ; Vol. 64, No. 2. pp. 120-125.
@article{eba8cde874334714a62c9bac5513eac3,
title = "Hepatoprotective activity of phenylethanoids from Cistanche deserticola",
abstract = "Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D- GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.",
keywords = "Carbon tetrachloride, Cistanche deserticola, D-galactosamine, Hepatoprotective activity, Orobanchaceae, Phenylethanoids",
author = "Quanbo Xiong and Kouji Hase and Yasuhiro Tezuka and Tadato Tani and Tsuneo Namba and Shigetoshi Kadota",
year = "1998",
language = "English",
volume = "64",
pages = "120--125",
journal = "Planta Medica",
issn = "0032-0943",
publisher = "Georg Thieme Verlag",
number = "2",

}

TY - JOUR

T1 - Hepatoprotective activity of phenylethanoids from Cistanche deserticola

AU - Xiong, Quanbo

AU - Hase, Kouji

AU - Tezuka, Yasuhiro

AU - Tani, Tadato

AU - Namba, Tsuneo

AU - Kadota, Shigetoshi

PY - 1998

Y1 - 1998

N2 - Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D- GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.

AB - Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D- GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.

KW - Carbon tetrachloride

KW - Cistanche deserticola

KW - D-galactosamine

KW - Hepatoprotective activity

KW - Orobanchaceae

KW - Phenylethanoids

UR - http://www.scopus.com/inward/record.url?scp=0031976872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031976872&partnerID=8YFLogxK

M3 - Article

VL - 64

SP - 120

EP - 125

JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 2

ER -