Hepatoprotective effect of Hovenia dulcis Thunb. on experimental liver injuries induced by carbon tetrachloride or D- galactosamine/lipopolysaccharide

Koji Hase; Mizue Ohsugi; Quanbo Xiong; Purusotam Basnet; Shigetoshi Kadota; Tsuneo Namba

doi:10.1248/bpb.20.381

Hepatoprotective effect of Hovenia dulcis Thunb. on experimental liver injuries induced by carbon tetrachloride or D- galactosamine/lipopolysaccharide

Koji Hase, Mizue Ohsugi, Quanbo Xiong, Purusotam Basnet, Shigetoshi Kadota, Tsuneo Namba

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

The hepatoprotective effects of the fruits of Hovenia dulcis Thunb. on chemically or immunologically induced experimental liver injury models were examined. The methanol extract showed significant hepatoprotective activity against CCl₄-toxicity in rats and D-galactosamine (D- GalN)/lipopolysaccharide-induced liver injury in mice. The methanol extract also significantly protected against CCl₄-toxicity in primary cultured rat hepatocytes. Hepatoprotective activity-guided fractionation and chemical analysis led to the isolation of an active constituent. (+)-ampelopsin (1) from the methanol extract.

Original language	English
Pages (from-to)	381-385
Number of pages	5
Journal	Biological and Pharmaceutical Bulletin
Volume	20
Issue number	4
DOIs	https://doi.org/10.1248/bpb.20.381
Publication status	Published - 1997 Apr
Externally published	Yes

Keywords

(+)-ampelopsin
D-galactosamine
Hovenia dulcis
carbon tetrachloride
hepatoprotective effect
lipopolysaccharide

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Access to Document

10.1248/bpb.20.381

Cite this

@article{5d6de43f0ed94de4aa0bfe53f7932fe3,

title = "Hepatoprotective effect of Hovenia dulcis Thunb. on experimental liver injuries induced by carbon tetrachloride or D- galactosamine/lipopolysaccharide",

abstract = "The hepatoprotective effects of the fruits of Hovenia dulcis Thunb. on chemically or immunologically induced experimental liver injury models were examined. The methanol extract showed significant hepatoprotective activity against CCl4-toxicity in rats and D-galactosamine (D- GalN)/lipopolysaccharide-induced liver injury in mice. The methanol extract also significantly protected against CCl4-toxicity in primary cultured rat hepatocytes. Hepatoprotective activity-guided fractionation and chemical analysis led to the isolation of an active constituent. (+)-ampelopsin (1) from the methanol extract.",

keywords = "(+)-ampelopsin, D-galactosamine, Hovenia dulcis, carbon tetrachloride, hepatoprotective effect, lipopolysaccharide",

author = "Koji Hase and Mizue Ohsugi and Quanbo Xiong and Purusotam Basnet and Shigetoshi Kadota and Tsuneo Namba",

year = "1997",

month = apr,

doi = "10.1248/bpb.20.381",

language = "English",

volume = "20",

pages = "381--385",

journal = "Biological and Pharmaceutical Bulletin",

issn = "0918-6158",

publisher = "Pharmaceutical Society of Japan",

number = "4",

}

TY - JOUR

T1 - Hepatoprotective effect of Hovenia dulcis Thunb. on experimental liver injuries induced by carbon tetrachloride or D- galactosamine/lipopolysaccharide

AU - Hase, Koji

AU - Ohsugi, Mizue

AU - Xiong, Quanbo

AU - Basnet, Purusotam

AU - Kadota, Shigetoshi

AU - Namba, Tsuneo

PY - 1997/4

Y1 - 1997/4

N2 - The hepatoprotective effects of the fruits of Hovenia dulcis Thunb. on chemically or immunologically induced experimental liver injury models were examined. The methanol extract showed significant hepatoprotective activity against CCl4-toxicity in rats and D-galactosamine (D- GalN)/lipopolysaccharide-induced liver injury in mice. The methanol extract also significantly protected against CCl4-toxicity in primary cultured rat hepatocytes. Hepatoprotective activity-guided fractionation and chemical analysis led to the isolation of an active constituent. (+)-ampelopsin (1) from the methanol extract.

AB - The hepatoprotective effects of the fruits of Hovenia dulcis Thunb. on chemically or immunologically induced experimental liver injury models were examined. The methanol extract showed significant hepatoprotective activity against CCl4-toxicity in rats and D-galactosamine (D- GalN)/lipopolysaccharide-induced liver injury in mice. The methanol extract also significantly protected against CCl4-toxicity in primary cultured rat hepatocytes. Hepatoprotective activity-guided fractionation and chemical analysis led to the isolation of an active constituent. (+)-ampelopsin (1) from the methanol extract.

KW - (+)-ampelopsin

KW - D-galactosamine

KW - Hovenia dulcis

KW - carbon tetrachloride

KW - hepatoprotective effect

KW - lipopolysaccharide

UR - http://www.scopus.com/inward/record.url?scp=0030958297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030958297&partnerID=8YFLogxK

U2 - 10.1248/bpb.20.381

DO - 10.1248/bpb.20.381

M3 - Article

C2 - 9145214

AN - SCOPUS:0030958297

SN - 0918-6158

VL - 20

SP - 381

EP - 385

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 4

ER -

Hepatoprotective effect of Hovenia dulcis Thunb. on experimental liver injuries induced by carbon tetrachloride or D- galactosamine/lipopolysaccharide

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this