Hepatoprotective effects of traditional medicines. isolation of the active constituent from seeds of celosia argentea

Koji Hase, Shigetoshi Kadota, Purusotam Basnet, Tsuneo Namba, Tooru Takahashi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The hepatoprotective effects of water extracts from twelve crude drugs were investigated. Among them, the water extracts of Cassia obtusifolia, Celosia argentea, Cucurbita moschata and Curcuma aeruginosa showed a significant protective effect on carbon tetrachloride induced liver injury in rats and D-galactosamine (D-GalN)/lipopolysaccharide (LPS) induced liver injury in mice. The water extract of C. argentea was found to be the most effective. The hepatoprotective activity guided fractionation of this extract led to the isolation of an active constituent. This component was named as celosian, and was found to be an acidic heteroglycan (molecular weight: 1.9 × 105) containing 4% of proteins.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalPhytotherapy Research
Volume11
Issue number8
Publication statusPublished - 1997 Dec 1
Externally publishedYes

Keywords

  • Carbon tetrachloride
  • Celosia argentea
  • Celosian
  • D-galactosamine
  • Hepatoprotective effects
  • Lipopolysaccharide

ASJC Scopus subject areas

  • Pharmacology

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