Hepatoprotective effects of traditional medicines. Isolation of the active constituent from seeds of Celosia argentea

Kouji Hase, Shigetoshi Kadota, Purusotam Basnet, Tsuneo Namba, Tooru Takahashi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The hepatoprotective effects of water extracts from twelve crude drugs were investigated. Among them, the water extracts of Cassia obtusifolia, Celosia argentea, Cucurbita moschata and Curcuma aeruginosa showed a significant protective effect on carbon tetrachloride induced liver injury in rats and D-galactosamine (D-GalN)/lipopolysaccharide (LPS) induced liver injury in mice. The water extract of C. argentea was found to be the most effective. The hepatoprotective activity guided fractionation of this extract led to the isolation of an active constituent. This component was named as celosian, and was found to be an acidic heteroglycan (molecular weight: 1.9 x 105) containing 4% of proteins.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalPhytotherapy Research
Volume10
Issue number5
DOIs
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Celosia
Traditional Medicine
Medicine
Seed
Seeds
Liver
Water
Cassia
Curcuma
Cucurbita
Galactosamine
Carbon Tetrachloride
Wounds and Injuries
Fractionation
Complex Mixtures
Lipopolysaccharides
Rats
Molecular Weight
Molecular weight
Pharmaceutical Preparations

Keywords

  • Carbon tetrachloride
  • Celosia argentea
  • Celosian
  • D-galactosamine
  • Hepatoprotective effect
  • Lipopolysaccharide

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Hepatoprotective effects of traditional medicines. Isolation of the active constituent from seeds of Celosia argentea. / Hase, Kouji; Kadota, Shigetoshi; Basnet, Purusotam; Namba, Tsuneo; Takahashi, Tooru.

In: Phytotherapy Research, Vol. 10, No. 5, 1996, p. 387-392.

Research output: Contribution to journalArticle

Hase, Kouji ; Kadota, Shigetoshi ; Basnet, Purusotam ; Namba, Tsuneo ; Takahashi, Tooru. / Hepatoprotective effects of traditional medicines. Isolation of the active constituent from seeds of Celosia argentea. In: Phytotherapy Research. 1996 ; Vol. 10, No. 5. pp. 387-392.
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