Abstract
The n-BuOH extract of Swertia japonica showed a significant hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The activity-guided fractionation led to the isolation of a new tetrahydroxanthone derivative, tetrahydroswertianolin (1), as well as two known iridoids, gentiopicroside (2) and sweroside (3). Their structures were elucidated by spectroscopic methods and chemical reactions. Of the three compounds, 2 and 3 possessed mild hepatoprotective activity at a dose range of 2550 mg/kg, whereas, 1 exhibited potent activity in a dose-dependent manner. The hepatoprotective effect of tetrahydroswertianolin (1) was stronger than that of glycyrrhizin which was used as a positive control.
Original language | English |
---|---|
Pages (from-to) | 1823-1827 |
Number of pages | 5 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 45 |
Issue number | 11 |
DOIs | |
Publication status | Published - 1997 |
Externally published | Yes |
Keywords
- Gentianaceae
- Gentiopicroside
- Hepa toprotective effect
- Sweroside
- Swertia japonica
- Tetrahydroswertianolin
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery