Hepatoprotective principles of Swertia japonica Makino on D- galactosamine/lipopolysaccharide-induced liver injury in mice

Koji Hase; L. I. Jianxin; Purusotam Basnet; Quanbo Xiong; Shuichi Takamura; Tsuneo Namba; Shigetoshi Kadota

doi:10.1248/cpb.45.1823

Hepatoprotective principles of Swertia japonica Makino on D- galactosamine/lipopolysaccharide-induced liver injury in mice

Koji Hase, L. I. Jianxin, Purusotam Basnet, Quanbo Xiong, Shuichi Takamura, Tsuneo Namba, Shigetoshi Kadota

Research output: Contribution to journal › Article

51 Citations (Scopus)

Abstract

The n-BuOH extract of Swertia japonica showed a significant hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The activity-guided fractionation led to the isolation of a new tetrahydroxanthone derivative, tetrahydroswertianolin (1), as well as two known iridoids, gentiopicroside (2) and sweroside (3). Their structures were elucidated by spectroscopic methods and chemical reactions. Of the three compounds, 2 and 3 possessed mild hepatoprotective activity at a dose range of 2550 mg/kg, whereas, 1 exhibited potent activity in a dose-dependent manner. The hepatoprotective effect of tetrahydroswertianolin (1) was stronger than that of glycyrrhizin which was used as a positive control.

Original language	English
Pages (from-to)	1823-1827
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	45
Issue number	11
DOIs	https://doi.org/10.1248/cpb.45.1823
Publication status	Published - 1997 Jan 1
Externally published	Yes

Fingerprint

Keywords

Gentianaceae
Gentiopicroside
Hepa toprotective effect
Sweroside
Swertia japonica
Tetrahydroswertianolin

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Cite this

Hase, K., Jianxin, L. I., Basnet, P., Xiong, Q., Takamura, S., Namba, T., & Kadota, S. (1997). Hepatoprotective principles of Swertia japonica Makino on D- galactosamine/lipopolysaccharide-induced liver injury in mice. Chemical and Pharmaceutical Bulletin, 45(11), 1823-1827. https://doi.org/10.1248/cpb.45.1823

Hepatoprotective principles of Swertia japonica Makino on D- galactosamine/lipopolysaccharide-induced liver injury in mice. / Hase, Koji; Jianxin, L. I.; Basnet, Purusotam; Xiong, Quanbo; Takamura, Shuichi; Namba, Tsuneo; Kadota, Shigetoshi.

In: Chemical and Pharmaceutical Bulletin, Vol. 45, No. 11, 01.01.1997, p. 1823-1827.

Research output: Contribution to journal › Article

@article{7ee2099e2b7c4f7095127dfdc074c551,

title = "Hepatoprotective principles of Swertia japonica Makino on D- galactosamine/lipopolysaccharide-induced liver injury in mice",

abstract = "The n-BuOH extract of Swertia japonica showed a significant hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The activity-guided fractionation led to the isolation of a new tetrahydroxanthone derivative, tetrahydroswertianolin (1), as well as two known iridoids, gentiopicroside (2) and sweroside (3). Their structures were elucidated by spectroscopic methods and chemical reactions. Of the three compounds, 2 and 3 possessed mild hepatoprotective activity at a dose range of 2550 mg/kg, whereas, 1 exhibited potent activity in a dose-dependent manner. The hepatoprotective effect of tetrahydroswertianolin (1) was stronger than that of glycyrrhizin which was used as a positive control.",

keywords = "Gentianaceae, Gentiopicroside, Hepa toprotective effect, Sweroside, Swertia japonica, Tetrahydroswertianolin",

author = "Koji Hase and Jianxin, {L. I.} and Purusotam Basnet and Quanbo Xiong and Shuichi Takamura and Tsuneo Namba and Shigetoshi Kadota",

year = "1997",

month = jan

day = "1",

doi = "10.1248/cpb.45.1823",

language = "English",

volume = "45",

pages = "1823--1827",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "11",

}

TY - JOUR

T1 - Hepatoprotective principles of Swertia japonica Makino on D- galactosamine/lipopolysaccharide-induced liver injury in mice

AU - Hase, Koji

AU - Jianxin, L. I.

AU - Basnet, Purusotam

AU - Xiong, Quanbo

AU - Takamura, Shuichi

AU - Namba, Tsuneo

AU - Kadota, Shigetoshi

PY - 1997/1/1

Y1 - 1997/1/1

N2 - The n-BuOH extract of Swertia japonica showed a significant hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The activity-guided fractionation led to the isolation of a new tetrahydroxanthone derivative, tetrahydroswertianolin (1), as well as two known iridoids, gentiopicroside (2) and sweroside (3). Their structures were elucidated by spectroscopic methods and chemical reactions. Of the three compounds, 2 and 3 possessed mild hepatoprotective activity at a dose range of 2550 mg/kg, whereas, 1 exhibited potent activity in a dose-dependent manner. The hepatoprotective effect of tetrahydroswertianolin (1) was stronger than that of glycyrrhizin which was used as a positive control.

AB - The n-BuOH extract of Swertia japonica showed a significant hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The activity-guided fractionation led to the isolation of a new tetrahydroxanthone derivative, tetrahydroswertianolin (1), as well as two known iridoids, gentiopicroside (2) and sweroside (3). Their structures were elucidated by spectroscopic methods and chemical reactions. Of the three compounds, 2 and 3 possessed mild hepatoprotective activity at a dose range of 2550 mg/kg, whereas, 1 exhibited potent activity in a dose-dependent manner. The hepatoprotective effect of tetrahydroswertianolin (1) was stronger than that of glycyrrhizin which was used as a positive control.

KW - Gentianaceae

KW - Gentiopicroside

KW - Hepa toprotective effect

KW - Sweroside

KW - Swertia japonica

KW - Tetrahydroswertianolin

UR - http://www.scopus.com/inward/record.url?scp=0347395046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347395046&partnerID=8YFLogxK

U2 - 10.1248/cpb.45.1823

DO - 10.1248/cpb.45.1823

M3 - Article

C2 - 9396160

AN - SCOPUS:0347395046

VL - 45

SP - 1823

EP - 1827

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 11

ER -

Access to Document

10.1248/cpb.45.1823