Hepatoprotective principles of Swertia japonica Makino on D- galactosamine/lipopolysaccharide-induced liver injury in mice

Koji Hase, L. I. Jianxin, Purusotam Basnet, Quanbo Xiong, Shuichi Takamura, Tsuneo Namba, Shigetoshi Kadota

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51 Citations (Scopus)

Abstract

The n-BuOH extract of Swertia japonica showed a significant hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The activity-guided fractionation led to the isolation of a new tetrahydroxanthone derivative, tetrahydroswertianolin (1), as well as two known iridoids, gentiopicroside (2) and sweroside (3). Their structures were elucidated by spectroscopic methods and chemical reactions. Of the three compounds, 2 and 3 possessed mild hepatoprotective activity at a dose range of 2550 mg/kg, whereas, 1 exhibited potent activity in a dose-dependent manner. The hepatoprotective effect of tetrahydroswertianolin (1) was stronger than that of glycyrrhizin which was used as a positive control.

Original languageEnglish
Pages (from-to)1823-1827
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume45
Issue number11
DOIs
Publication statusPublished - 1997 Jan 1
Externally publishedYes

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Keywords

  • Gentianaceae
  • Gentiopicroside
  • Hepa toprotective effect
  • Sweroside
  • Swertia japonica
  • Tetrahydroswertianolin

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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