Hepatoprotective principles of Swertia japonica Makino on D- galactosamine/lipopolysaccharide-induced liver injury in mice

Koji Hase; L. I. Jianxin; Purusotam Basnet; Quanbo Xiong; Shuichi Takamura; Tsuneo Namba; Shigetoshi Kadota

doi:10.1248/cpb.45.1823

Hepatoprotective principles of Swertia japonica Makino on D- galactosamine/lipopolysaccharide-induced liver injury in mice

Koji Hase, L. I. Jianxin, Purusotam Basnet, Quanbo Xiong, Shuichi Takamura, Tsuneo Namba, Shigetoshi Kadota

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

The n-BuOH extract of Swertia japonica showed a significant hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The activity-guided fractionation led to the isolation of a new tetrahydroxanthone derivative, tetrahydroswertianolin (1), as well as two known iridoids, gentiopicroside (2) and sweroside (3). Their structures were elucidated by spectroscopic methods and chemical reactions. Of the three compounds, 2 and 3 possessed mild hepatoprotective activity at a dose range of 2550 mg/kg, whereas, 1 exhibited potent activity in a dose-dependent manner. The hepatoprotective effect of tetrahydroswertianolin (1) was stronger than that of glycyrrhizin which was used as a positive control.

Original language	English
Pages (from-to)	1823-1827
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	45
Issue number	11
DOIs	https://doi.org/10.1248/cpb.45.1823
Publication status	Published - 1997
Externally published	Yes

Keywords

Gentianaceae
Gentiopicroside
Hepa toprotective effect
Sweroside
Swertia japonica
Tetrahydroswertianolin

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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title = "Hepatoprotective principles of Swertia japonica Makino on D- galactosamine/lipopolysaccharide-induced liver injury in mice",

abstract = "The n-BuOH extract of Swertia japonica showed a significant hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The activity-guided fractionation led to the isolation of a new tetrahydroxanthone derivative, tetrahydroswertianolin (1), as well as two known iridoids, gentiopicroside (2) and sweroside (3). Their structures were elucidated by spectroscopic methods and chemical reactions. Of the three compounds, 2 and 3 possessed mild hepatoprotective activity at a dose range of 2550 mg/kg, whereas, 1 exhibited potent activity in a dose-dependent manner. The hepatoprotective effect of tetrahydroswertianolin (1) was stronger than that of glycyrrhizin which was used as a positive control.",

keywords = "Gentianaceae, Gentiopicroside, Hepa toprotective effect, Sweroside, Swertia japonica, Tetrahydroswertianolin",

author = "Koji Hase and Jianxin, {L. I.} and Purusotam Basnet and Quanbo Xiong and Shuichi Takamura and Tsuneo Namba and Shigetoshi Kadota",

year = "1997",

doi = "10.1248/cpb.45.1823",

language = "English",

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pages = "1823--1827",

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AU - Hase, Koji

AU - Jianxin, L. I.

AU - Basnet, Purusotam

AU - Xiong, Quanbo

AU - Takamura, Shuichi

AU - Namba, Tsuneo

AU - Kadota, Shigetoshi

PY - 1997

Y1 - 1997

N2 - The n-BuOH extract of Swertia japonica showed a significant hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The activity-guided fractionation led to the isolation of a new tetrahydroxanthone derivative, tetrahydroswertianolin (1), as well as two known iridoids, gentiopicroside (2) and sweroside (3). Their structures were elucidated by spectroscopic methods and chemical reactions. Of the three compounds, 2 and 3 possessed mild hepatoprotective activity at a dose range of 2550 mg/kg, whereas, 1 exhibited potent activity in a dose-dependent manner. The hepatoprotective effect of tetrahydroswertianolin (1) was stronger than that of glycyrrhizin which was used as a positive control.

AB - The n-BuOH extract of Swertia japonica showed a significant hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The activity-guided fractionation led to the isolation of a new tetrahydroxanthone derivative, tetrahydroswertianolin (1), as well as two known iridoids, gentiopicroside (2) and sweroside (3). Their structures were elucidated by spectroscopic methods and chemical reactions. Of the three compounds, 2 and 3 possessed mild hepatoprotective activity at a dose range of 2550 mg/kg, whereas, 1 exhibited potent activity in a dose-dependent manner. The hepatoprotective effect of tetrahydroswertianolin (1) was stronger than that of glycyrrhizin which was used as a positive control.

KW - Gentianaceae

KW - Gentiopicroside

KW - Hepa toprotective effect

KW - Sweroside

KW - Swertia japonica

KW - Tetrahydroswertianolin

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JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

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ER -

Hepatoprotective principles of Swertia japonica Makino on D- galactosamine/lipopolysaccharide-induced liver injury in mice

Abstract

Keywords

ASJC Scopus subject areas

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