Hereditary cataract of the Nakano mouse

Makoto Takehana

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The Nakano mouse is a hereditary cataract model whose most characteristic change is a deficiency in lens Na+,K+-ATPase. Consequently, there is a change in lenticular sodium and potassium ion levels just before cataract formation. The amounts of calcium ion also change suddenly in the lens, with accumulated levels higher than any other type of cataract. Other biochemical changes coincide with the development of lens opacity, including decreases in the levels of reduced glutathione, ATP, biosynthetic activity of proteoglycans in epithelial cells, and the permeability of gap junction channels in fiber cells. The decrease in the activity of Na+,K+-ATPase results in changes in a number of key metabolic parameters, resulting in the eventual opacification of the Nakano mouse lens at approximately 30 days of age.

Original languageEnglish
Pages (from-to)671-676
Number of pages6
JournalExperimental Eye Research
Volume50
Issue number6
DOIs
Publication statusPublished - 1990 Jun

Keywords

  • Na,K-ATPase
  • Nakano mouse
  • cation
  • gap junction
  • glycosaminoglycan
  • lens implantation
  • morphology

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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