Hereditary palmoplantar keratoderma "clinical and genetic differential diagnosis"

Tomo Sakiyama, Akiharu Kubo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Hereditary palmoplantar keratoderma (PPK) is a heterogeneous group of disorders characterized by hyperkeratosis of the palm and the sole skin. Hereditary PPK are divided into four groups - diffuse, focal, striate and punctate PPK - according to the clinical patterns of the hyperkeratotic lesions. Each group includes simple PPK, without associated features, and PPK with associated features, such as involvement of nails, teeth and other organs. PPK have been classified by a clinically based descriptive system. In recent years, many causative genes of PPK have been identified, which has confirmed and/or rearranged the traditional classifications. It is now important to diagnose PPK by a combination of the traditional morphological classification and genetic testing. In this review, we focus on PPK without associated features and introduce their morphological features, genetic backgrounds and new findings from the last decade.

Original languageEnglish
Pages (from-to)264-274
Number of pages11
JournalJournal of Dermatology
Volume43
Issue number3
DOIs
Publication statusPublished - 2016 Mar 1

Fingerprint

Palmoplantar Keratoderma
Differential Diagnosis
Genetic Testing
Nails
Tooth

Keywords

  • diffuse
  • focal
  • punctate
  • striate
  • transgrediens

ASJC Scopus subject areas

  • Dermatology

Cite this

Hereditary palmoplantar keratoderma "clinical and genetic differential diagnosis". / Sakiyama, Tomo; Kubo, Akiharu.

In: Journal of Dermatology, Vol. 43, No. 3, 01.03.2016, p. 264-274.

Research output: Contribution to journalArticle

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