Heterogeneous Heterobimetallic Catalysis Enabling Expeditious Access to CF3-Containing vic-Amino Alcohols

Tomoya Karasawa, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


A highly anti-selective catalytic asymmetric nitroaldol reaction of trifluoromethyl ketones based on Nd/Na and Pr/Na heterobimetallic catalysts was developed. These catalysts function as heterogeneous catalysts to engage nitroethane and a range of trifluoromethyl ketones in a stereoselective assembly to afford CF3-appended vic-nitroalkanols that could be readily converted to enantioenriched vic-amino alcohols, which are privileged structural motifs in medicinal chemistry.

Original languageEnglish
Pages (from-to)308-311
Number of pages4
JournalOrganic Letters
Issue number1
Publication statusPublished - 2018 Jan 5
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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