@article{c006b6934b3544a299fc01e566368a60,
title = "Heterogeneous Heterobimetallic Catalysis Enabling Expeditious Access to CF3-Containing vic-Amino Alcohols",
abstract = "A highly anti-selective catalytic asymmetric nitroaldol reaction of trifluoromethyl ketones based on Nd/Na and Pr/Na heterobimetallic catalysts was developed. These catalysts function as heterogeneous catalysts to engage nitroethane and a range of trifluoromethyl ketones in a stereoselective assembly to afford CF3-appended vic-nitroalkanols that could be readily converted to enantioenriched vic-amino alcohols, which are privileged structural motifs in medicinal chemistry.",
author = "Tomoya Karasawa and Naoya Kumagai and Masakatsu Shibasaki",
note = "Funding Information: This work was financially supported by ACT-C (JPMJCR12YO) from JST and by KAKENHI (17H03025 and JP16H01043 in Precisely Designed Catalysts with Customized Scaffolding) from JSPS and MEXT. Dr. Ryuichi Sawa, Ms. Yumiko Kubota, and Dr. Kiyoko Iijima at the Institute of Microbial Chemistry are gratefully acknowledged for their assistance with the spectroscopic analysis. We thank Dr. Tomoyuki Kimura at the Institute of Microbial Chemistry for assistance with X-ray crystallography. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2018",
month = jan,
day = "5",
doi = "10.1021/acs.orglett.7b03767",
language = "English",
volume = "20",
pages = "308--311",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "1",
}