Heterogeneous Heterobimetallic Catalysis Enabling Expeditious Access to CF3-Containing vic-Amino Alcohols

Tomoya Karasawa, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

A highly anti-selective catalytic asymmetric nitroaldol reaction of trifluoromethyl ketones based on Nd/Na and Pr/Na heterobimetallic catalysts was developed. These catalysts function as heterogeneous catalysts to engage nitroethane and a range of trifluoromethyl ketones in a stereoselective assembly to afford CF3-appended vic-nitroalkanols that could be readily converted to enantioenriched vic-amino alcohols, which are privileged structural motifs in medicinal chemistry.

Original languageEnglish
Pages (from-to)308-311
Number of pages4
JournalOrganic Letters
Volume20
Issue number1
DOIs
Publication statusPublished - 2018 Jan 5
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Heterogeneous Heterobimetallic Catalysis Enabling Expeditious Access to CF<sub>3</sub>-Containing vic-Amino Alcohols'. Together they form a unique fingerprint.

Cite this