Abstract
The bioassay-guided fractionation of the cytotoxic constituents of the Okinawan ascidian Didemnum molle led to the isolation of hexamollamide (1), a hexapeptide. The gross structure and relative stereostructure of 1 were established by spectroscopic analysis including 2D NMR techniques and single-crystal X-ray diffraction analysis. The absolute stereostructure was determined by chiral HPLC analysis of acid hydrolysates of 1. Hexamollamide (1) exhibits moderate cytotoxicity against HeLa S3 cells.
Original language | English |
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Pages (from-to) | 5297-5299 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 49 |
Issue number | 36 |
DOIs | |
Publication status | Published - 2008 Sep 1 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry