Abstract
The bioassay-guided fractionation of the cytotoxic constituents of the Okinawan ascidian Didemnum molle led to the isolation of hexamollamide (1), a hexapeptide. The gross structure and relative stereostructure of 1 were established by spectroscopic analysis including 2D NMR techniques and single-crystal X-ray diffraction analysis. The absolute stereostructure was determined by chiral HPLC analysis of acid hydrolysates of 1. Hexamollamide (1) exhibits moderate cytotoxicity against HeLa S3 cells.
| Original language | English |
|---|---|
| Pages (from-to) | 5297-5299 |
| Number of pages | 3 |
| Journal | Tetrahedron Letters |
| Volume | 49 |
| Issue number | 36 |
| DOIs | |
| Publication status | Published - 2008 Sep 1 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Teruya, T., Sasaki, H., & Suenaga, K. (2008). Hexamollamide, a hexapeptide from an Okinawan ascidian Didemnum molle. Tetrahedron Letters, 49(36), 5297-5299. https://doi.org/10.1016/j.tetlet.2008.06.086