Hexamollamide, a hexapeptide from an Okinawan ascidian Didemnum molle

Toshiaki Teruya, Hiroaki Sasaki, Kiyotake Suenaga

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The bioassay-guided fractionation of the cytotoxic constituents of the Okinawan ascidian Didemnum molle led to the isolation of hexamollamide (1), a hexapeptide. The gross structure and relative stereostructure of 1 were established by spectroscopic analysis including 2D NMR techniques and single-crystal X-ray diffraction analysis. The absolute stereostructure was determined by chiral HPLC analysis of acid hydrolysates of 1. Hexamollamide (1) exhibits moderate cytotoxicity against HeLa S3 cells.

Original languageEnglish
Pages (from-to)5297-5299
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number36
DOIs
Publication statusPublished - 2008 Sep 1

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Urochordata
Spectroscopic analysis
Bioassay
Cytotoxicity
Fractionation
HeLa Cells
X-Ray Diffraction
Biological Assay
X ray diffraction analysis
High Pressure Liquid Chromatography
Nuclear magnetic resonance
Single crystals
Acids

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Hexamollamide, a hexapeptide from an Okinawan ascidian Didemnum molle. / Teruya, Toshiaki; Sasaki, Hiroaki; Suenaga, Kiyotake.

In: Tetrahedron Letters, Vol. 49, No. 36, 01.09.2008, p. 5297-5299.

Research output: Contribution to journalArticle

Teruya, Toshiaki ; Sasaki, Hiroaki ; Suenaga, Kiyotake. / Hexamollamide, a hexapeptide from an Okinawan ascidian Didemnum molle. In: Tetrahedron Letters. 2008 ; Vol. 49, No. 36. pp. 5297-5299.
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