Abstract
The bioassay-guided fractionation of the cytotoxic constituents of the Okinawan ascidian Didemnum molle led to the isolation of hexamollamide (1), a hexapeptide. The gross structure and relative stereostructure of 1 were established by spectroscopic analysis including 2D NMR techniques and single-crystal X-ray diffraction analysis. The absolute stereostructure was determined by chiral HPLC analysis of acid hydrolysates of 1. Hexamollamide (1) exhibits moderate cytotoxicity against HeLa S3 cells.
| Original language | English |
|---|---|
| Pages (from-to) | 5297-5299 |
| Number of pages | 3 |
| Journal | Tetrahedron Letters |
| Volume | 49 |
| Issue number | 36 |
| DOIs | |
| Publication status | Published - 2008 Sep 1 |
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ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Hexamollamide, a hexapeptide from an Okinawan ascidian Didemnum molle. / Teruya, Toshiaki; Sasaki, Hiroaki; Suenaga, Kiyotake.
In: Tetrahedron Letters, Vol. 49, No. 36, 01.09.2008, p. 5297-5299.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hexamollamide, a hexapeptide from an Okinawan ascidian Didemnum molle
AU - Teruya, Toshiaki
AU - Sasaki, Hiroaki
AU - Suenaga, Kiyotake
PY - 2008/9/1
Y1 - 2008/9/1
N2 - The bioassay-guided fractionation of the cytotoxic constituents of the Okinawan ascidian Didemnum molle led to the isolation of hexamollamide (1), a hexapeptide. The gross structure and relative stereostructure of 1 were established by spectroscopic analysis including 2D NMR techniques and single-crystal X-ray diffraction analysis. The absolute stereostructure was determined by chiral HPLC analysis of acid hydrolysates of 1. Hexamollamide (1) exhibits moderate cytotoxicity against HeLa S3 cells.
AB - The bioassay-guided fractionation of the cytotoxic constituents of the Okinawan ascidian Didemnum molle led to the isolation of hexamollamide (1), a hexapeptide. The gross structure and relative stereostructure of 1 were established by spectroscopic analysis including 2D NMR techniques and single-crystal X-ray diffraction analysis. The absolute stereostructure was determined by chiral HPLC analysis of acid hydrolysates of 1. Hexamollamide (1) exhibits moderate cytotoxicity against HeLa S3 cells.
UR - http://www.scopus.com/inward/record.url?scp=47549088623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47549088623&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2008.06.086
DO - 10.1016/j.tetlet.2008.06.086
M3 - Article
AN - SCOPUS:47549088623
VL - 49
SP - 5297
EP - 5299
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 36
ER -