Hidden osteophyte formation on plain X-ray is the predictive factor for development of knee osteoarthritis after 48 months - data from the Osteoarthritis Initiative

J. Katsuragi, T. Sasho, S. Yamaguchi, Yasunori Sato, A. Watanabe, R. Akagi, Y. Muramatsu, S. Mukoyama, Y. Akatsu, T. Fukawa, J. Endo, H. Hoshi, Y. Yamamoto, T. Sasaki, K. Takahashi

Research output: Contribution to journalArticle

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Abstract

Objective: To examine whether the detection of osteophytes anywhere in the knee could serve as a pre-radiographic biomarker for osteoarthritis (OA) development. Methods: Baseline magnetic resonance imaging (MRIs) of 132 participants in the Osteoarthritis Initiative (OAI) were studied. Based on radiographs, 66 knees were assessed as osteoarthritis-free (no-osteoarthritis [NOA], or Kellgren/Lawrence [K/L] severity grade 0/1 both at baseline and 48 months), and another 66 knees were assessed as having radiographic OA changes (pre-radiographic osteoarthritis [PROA], or with K/L grade 0/1at baseline and grade ≥2at 48 months). Using baseline MRI data, we examined eight sites of osteophyte formation: the medial and lateral femoral condyle (MFC and LFC, respectively); medial and lateral tibial plateau (MTP and LTP, respectively); medial and lateral facets of the patellofemoral joint (PM and PL, respectively); tibial spine (TS); and femoral intercondylar notch (IC). Knee joint osteophyte size was assessed via the 8-point marginal osteophytes item of the whole-organ magnetic resonance imaging score (WORMS). The frequencies and distributions of osteophytes were compared between groups. Results: Mild-size osteophytes (defined as score ≥2) were observed more frequently at the MFC (P=0.00278), MTP (P=0.0046), TS (P=0.0146), PM (P<0.0001), PL (P=0.0012), and IC (P<0.0001) in PROA knees than in NOA knees. Moderate-size osteophytes (defined as score ≥4) were more frequently observed in PROA knees than in NOA knees only at the IC (P<0.0001). Conclusion: Knees with osteophyte formation at the IC, even those of K/L severity grade 0/1, are at risk for the development of radiographic OA by 48 months.

Original languageEnglish
Pages (from-to)383-390
Number of pages8
JournalOsteoarthritis and Cartilage
Volume23
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1
Externally publishedYes

Fingerprint

Osteophyte
Knee Osteoarthritis
Magnetic resonance
Osteoarthritis
X-Rays
Imaging techniques
X rays
Knee
Biomarkers
Magnetic Resonance Imaging
Thigh
Spine
Patellofemoral Joint
Zygapophyseal Joint
Knee Joint
Bone and Bones

Keywords

  • Intercondylar notch
  • Magnetic resonance imaging
  • Osteoarthritis
  • Osteoarthritis Initiative
  • Osteophyte formation
  • Pre-radiographic osteoarthritis

ASJC Scopus subject areas

  • Rheumatology
  • Biomedical Engineering
  • Orthopedics and Sports Medicine

Cite this

Hidden osteophyte formation on plain X-ray is the predictive factor for development of knee osteoarthritis after 48 months - data from the Osteoarthritis Initiative. / Katsuragi, J.; Sasho, T.; Yamaguchi, S.; Sato, Yasunori; Watanabe, A.; Akagi, R.; Muramatsu, Y.; Mukoyama, S.; Akatsu, Y.; Fukawa, T.; Endo, J.; Hoshi, H.; Yamamoto, Y.; Sasaki, T.; Takahashi, K.

In: Osteoarthritis and Cartilage, Vol. 23, No. 3, 01.03.2015, p. 383-390.

Research output: Contribution to journalArticle

Katsuragi, J, Sasho, T, Yamaguchi, S, Sato, Y, Watanabe, A, Akagi, R, Muramatsu, Y, Mukoyama, S, Akatsu, Y, Fukawa, T, Endo, J, Hoshi, H, Yamamoto, Y, Sasaki, T & Takahashi, K 2015, 'Hidden osteophyte formation on plain X-ray is the predictive factor for development of knee osteoarthritis after 48 months - data from the Osteoarthritis Initiative', Osteoarthritis and Cartilage, vol. 23, no. 3, pp. 383-390. https://doi.org/10.1016/j.joca.2014.11.026
Katsuragi, J. ; Sasho, T. ; Yamaguchi, S. ; Sato, Yasunori ; Watanabe, A. ; Akagi, R. ; Muramatsu, Y. ; Mukoyama, S. ; Akatsu, Y. ; Fukawa, T. ; Endo, J. ; Hoshi, H. ; Yamamoto, Y. ; Sasaki, T. ; Takahashi, K. / Hidden osteophyte formation on plain X-ray is the predictive factor for development of knee osteoarthritis after 48 months - data from the Osteoarthritis Initiative. In: Osteoarthritis and Cartilage. 2015 ; Vol. 23, No. 3. pp. 383-390.
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AU - Sasho, T.

AU - Yamaguchi, S.

AU - Sato, Yasunori

AU - Watanabe, A.

AU - Akagi, R.

AU - Muramatsu, Y.

AU - Mukoyama, S.

AU - Akatsu, Y.

AU - Fukawa, T.

AU - Endo, J.

AU - Hoshi, H.

AU - Yamamoto, Y.

AU - Sasaki, T.

AU - Takahashi, K.

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N2 - Objective: To examine whether the detection of osteophytes anywhere in the knee could serve as a pre-radiographic biomarker for osteoarthritis (OA) development. Methods: Baseline magnetic resonance imaging (MRIs) of 132 participants in the Osteoarthritis Initiative (OAI) were studied. Based on radiographs, 66 knees were assessed as osteoarthritis-free (no-osteoarthritis [NOA], or Kellgren/Lawrence [K/L] severity grade 0/1 both at baseline and 48 months), and another 66 knees were assessed as having radiographic OA changes (pre-radiographic osteoarthritis [PROA], or with K/L grade 0/1at baseline and grade ≥2at 48 months). Using baseline MRI data, we examined eight sites of osteophyte formation: the medial and lateral femoral condyle (MFC and LFC, respectively); medial and lateral tibial plateau (MTP and LTP, respectively); medial and lateral facets of the patellofemoral joint (PM and PL, respectively); tibial spine (TS); and femoral intercondylar notch (IC). Knee joint osteophyte size was assessed via the 8-point marginal osteophytes item of the whole-organ magnetic resonance imaging score (WORMS). The frequencies and distributions of osteophytes were compared between groups. Results: Mild-size osteophytes (defined as score ≥2) were observed more frequently at the MFC (P=0.00278), MTP (P=0.0046), TS (P=0.0146), PM (P<0.0001), PL (P=0.0012), and IC (P<0.0001) in PROA knees than in NOA knees. Moderate-size osteophytes (defined as score ≥4) were more frequently observed in PROA knees than in NOA knees only at the IC (P<0.0001). Conclusion: Knees with osteophyte formation at the IC, even those of K/L severity grade 0/1, are at risk for the development of radiographic OA by 48 months.

AB - Objective: To examine whether the detection of osteophytes anywhere in the knee could serve as a pre-radiographic biomarker for osteoarthritis (OA) development. Methods: Baseline magnetic resonance imaging (MRIs) of 132 participants in the Osteoarthritis Initiative (OAI) were studied. Based on radiographs, 66 knees were assessed as osteoarthritis-free (no-osteoarthritis [NOA], or Kellgren/Lawrence [K/L] severity grade 0/1 both at baseline and 48 months), and another 66 knees were assessed as having radiographic OA changes (pre-radiographic osteoarthritis [PROA], or with K/L grade 0/1at baseline and grade ≥2at 48 months). Using baseline MRI data, we examined eight sites of osteophyte formation: the medial and lateral femoral condyle (MFC and LFC, respectively); medial and lateral tibial plateau (MTP and LTP, respectively); medial and lateral facets of the patellofemoral joint (PM and PL, respectively); tibial spine (TS); and femoral intercondylar notch (IC). Knee joint osteophyte size was assessed via the 8-point marginal osteophytes item of the whole-organ magnetic resonance imaging score (WORMS). The frequencies and distributions of osteophytes were compared between groups. Results: Mild-size osteophytes (defined as score ≥2) were observed more frequently at the MFC (P=0.00278), MTP (P=0.0046), TS (P=0.0146), PM (P<0.0001), PL (P=0.0012), and IC (P<0.0001) in PROA knees than in NOA knees. Moderate-size osteophytes (defined as score ≥4) were more frequently observed in PROA knees than in NOA knees only at the IC (P<0.0001). Conclusion: Knees with osteophyte formation at the IC, even those of K/L severity grade 0/1, are at risk for the development of radiographic OA by 48 months.

KW - Intercondylar notch

KW - Magnetic resonance imaging

KW - Osteoarthritis

KW - Osteoarthritis Initiative

KW - Osteophyte formation

KW - Pre-radiographic osteoarthritis

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