High blood pressure in middle age is associated with a future decline in activities of daily living. NIPPON DATA80

A. Hozawa, Tomonori Okamura, Y. Murakami, T. Kadowaki, N. Okuda, N. Takashima, T. Hayakawa, Y. Kita, K. Miura, Y. Nakamura, A. Okayama, H. Ueshima

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Although several studies have reported on the relation between high blood pressure (BP) and impaired activities of daily living (ADL), only a few studies have reported on the relation of high BP in middle-aged subjects with future impaired ADL. Furthermore, no studies reported an excess impaired ADL due to non-normal BP. Using ADL 1999 data, we compared data from NIPPON DATA80 survivors without impaired ADL (N = 1816) with those with impaired ADL (N = 75) using baseline BP information collected in 1980. We analysed participants who were aged 47-59 years at baseline. Multiple adjusted logistic regression analyses were used to estimate the risk of impaired ADL, according to baseline BP categories using Joint National Committee 7 guidelines (normal BP, prehypertension, stage 1 hypertension (HT) and stage 2 HT). Subjects who used antihypertensive medications were classified as having stage 2 HT. We calculated excess impaired ADL due to non-normal BP. Compared with normal BP categories, the adjusted odds ratio (OR) and 95% confidence interval (CI) of having impaired ADL was higher in subjects with prehypertension (OR = 1.50, 95% CI: 0.55-4.09), stage 1 HT (OR = 1.56, 95% CI: 0.56-4.32) and stage 2 HT (OR = 2.96, 95% CI: 1.09-8.05). Non-normal BP explained 45% (33.7/75) of impaired ADL. A positive relation of BP categories with the composite end point of mortality and impaired ADL was also observed. In conclusion, controlling BP in middle age may prevent deaths and future ADL decline.

Original languageEnglish
Pages (from-to)546-552
Number of pages7
JournalJournal of Human Hypertension
Volume23
Issue number8
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Activities of Daily Living
Hypertension
Blood Pressure
Odds Ratio
Prehypertension
Confidence Intervals
Antihypertensive Agents
Survivors
Logistic Models
Regression Analysis
Guidelines

ASJC Scopus subject areas

  • Internal Medicine

Cite this

High blood pressure in middle age is associated with a future decline in activities of daily living. NIPPON DATA80. / Hozawa, A.; Okamura, Tomonori; Murakami, Y.; Kadowaki, T.; Okuda, N.; Takashima, N.; Hayakawa, T.; Kita, Y.; Miura, K.; Nakamura, Y.; Okayama, A.; Ueshima, H.

In: Journal of Human Hypertension, Vol. 23, No. 8, 2009, p. 546-552.

Research output: Contribution to journalArticle

Hozawa, A, Okamura, T, Murakami, Y, Kadowaki, T, Okuda, N, Takashima, N, Hayakawa, T, Kita, Y, Miura, K, Nakamura, Y, Okayama, A & Ueshima, H 2009, 'High blood pressure in middle age is associated with a future decline in activities of daily living. NIPPON DATA80', Journal of Human Hypertension, vol. 23, no. 8, pp. 546-552. https://doi.org/10.1038/jhh.2008.155
Hozawa, A. ; Okamura, Tomonori ; Murakami, Y. ; Kadowaki, T. ; Okuda, N. ; Takashima, N. ; Hayakawa, T. ; Kita, Y. ; Miura, K. ; Nakamura, Y. ; Okayama, A. ; Ueshima, H. / High blood pressure in middle age is associated with a future decline in activities of daily living. NIPPON DATA80. In: Journal of Human Hypertension. 2009 ; Vol. 23, No. 8. pp. 546-552.
@article{f6f05ea4ce2544aaa97f7553891048b9,
title = "High blood pressure in middle age is associated with a future decline in activities of daily living. NIPPON DATA80",
abstract = "Although several studies have reported on the relation between high blood pressure (BP) and impaired activities of daily living (ADL), only a few studies have reported on the relation of high BP in middle-aged subjects with future impaired ADL. Furthermore, no studies reported an excess impaired ADL due to non-normal BP. Using ADL 1999 data, we compared data from NIPPON DATA80 survivors without impaired ADL (N = 1816) with those with impaired ADL (N = 75) using baseline BP information collected in 1980. We analysed participants who were aged 47-59 years at baseline. Multiple adjusted logistic regression analyses were used to estimate the risk of impaired ADL, according to baseline BP categories using Joint National Committee 7 guidelines (normal BP, prehypertension, stage 1 hypertension (HT) and stage 2 HT). Subjects who used antihypertensive medications were classified as having stage 2 HT. We calculated excess impaired ADL due to non-normal BP. Compared with normal BP categories, the adjusted odds ratio (OR) and 95{\%} confidence interval (CI) of having impaired ADL was higher in subjects with prehypertension (OR = 1.50, 95{\%} CI: 0.55-4.09), stage 1 HT (OR = 1.56, 95{\%} CI: 0.56-4.32) and stage 2 HT (OR = 2.96, 95{\%} CI: 1.09-8.05). Non-normal BP explained 45{\%} (33.7/75) of impaired ADL. A positive relation of BP categories with the composite end point of mortality and impaired ADL was also observed. In conclusion, controlling BP in middle age may prevent deaths and future ADL decline.",
author = "A. Hozawa and Tomonori Okamura and Y. Murakami and T. Kadowaki and N. Okuda and N. Takashima and T. Hayakawa and Y. Kita and K. Miura and Y. Nakamura and A. Okayama and H. Ueshima",
year = "2009",
doi = "10.1038/jhh.2008.155",
language = "English",
volume = "23",
pages = "546--552",
journal = "Journal of Human Hypertension",
issn = "0950-9240",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - High blood pressure in middle age is associated with a future decline in activities of daily living. NIPPON DATA80

AU - Hozawa, A.

AU - Okamura, Tomonori

AU - Murakami, Y.

AU - Kadowaki, T.

AU - Okuda, N.

AU - Takashima, N.

AU - Hayakawa, T.

AU - Kita, Y.

AU - Miura, K.

AU - Nakamura, Y.

AU - Okayama, A.

AU - Ueshima, H.

PY - 2009

Y1 - 2009

N2 - Although several studies have reported on the relation between high blood pressure (BP) and impaired activities of daily living (ADL), only a few studies have reported on the relation of high BP in middle-aged subjects with future impaired ADL. Furthermore, no studies reported an excess impaired ADL due to non-normal BP. Using ADL 1999 data, we compared data from NIPPON DATA80 survivors without impaired ADL (N = 1816) with those with impaired ADL (N = 75) using baseline BP information collected in 1980. We analysed participants who were aged 47-59 years at baseline. Multiple adjusted logistic regression analyses were used to estimate the risk of impaired ADL, according to baseline BP categories using Joint National Committee 7 guidelines (normal BP, prehypertension, stage 1 hypertension (HT) and stage 2 HT). Subjects who used antihypertensive medications were classified as having stage 2 HT. We calculated excess impaired ADL due to non-normal BP. Compared with normal BP categories, the adjusted odds ratio (OR) and 95% confidence interval (CI) of having impaired ADL was higher in subjects with prehypertension (OR = 1.50, 95% CI: 0.55-4.09), stage 1 HT (OR = 1.56, 95% CI: 0.56-4.32) and stage 2 HT (OR = 2.96, 95% CI: 1.09-8.05). Non-normal BP explained 45% (33.7/75) of impaired ADL. A positive relation of BP categories with the composite end point of mortality and impaired ADL was also observed. In conclusion, controlling BP in middle age may prevent deaths and future ADL decline.

AB - Although several studies have reported on the relation between high blood pressure (BP) and impaired activities of daily living (ADL), only a few studies have reported on the relation of high BP in middle-aged subjects with future impaired ADL. Furthermore, no studies reported an excess impaired ADL due to non-normal BP. Using ADL 1999 data, we compared data from NIPPON DATA80 survivors without impaired ADL (N = 1816) with those with impaired ADL (N = 75) using baseline BP information collected in 1980. We analysed participants who were aged 47-59 years at baseline. Multiple adjusted logistic regression analyses were used to estimate the risk of impaired ADL, according to baseline BP categories using Joint National Committee 7 guidelines (normal BP, prehypertension, stage 1 hypertension (HT) and stage 2 HT). Subjects who used antihypertensive medications were classified as having stage 2 HT. We calculated excess impaired ADL due to non-normal BP. Compared with normal BP categories, the adjusted odds ratio (OR) and 95% confidence interval (CI) of having impaired ADL was higher in subjects with prehypertension (OR = 1.50, 95% CI: 0.55-4.09), stage 1 HT (OR = 1.56, 95% CI: 0.56-4.32) and stage 2 HT (OR = 2.96, 95% CI: 1.09-8.05). Non-normal BP explained 45% (33.7/75) of impaired ADL. A positive relation of BP categories with the composite end point of mortality and impaired ADL was also observed. In conclusion, controlling BP in middle age may prevent deaths and future ADL decline.

UR - http://www.scopus.com/inward/record.url?scp=67849084536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67849084536&partnerID=8YFLogxK

U2 - 10.1038/jhh.2008.155

DO - 10.1038/jhh.2008.155

M3 - Article

C2 - 19092846

AN - SCOPUS:67849084536

VL - 23

SP - 546

EP - 552

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

SN - 0950-9240

IS - 8

ER -