High concentrations of interleukin-8 in bronchoalveolar lavage fluid from a patient with adult respiratory distress syndrome

H. Matsubara, Seitaro Fujishima, K. Sayama, Y. Akasaka, F. Yamasawa, A. Ishizaka, K. Yamaguchi, M. Kanazawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 75-year-old man was admitted to the hospital due to acute onset of a dry cough and dyspnea on exertion. Arterial blood gas analysis showed hypoxemia (PaO2 = 63 Torr) on room air. Chest radiography and computed tomography showed diffuse bilateral infiltrates. Adult respiratory distress syndrome was diagnosed from the findings described above and from the lack of evidence of left heart failure. Diffuse alveolar damage was confirmed at autopsy. During the course of his illness, the patient underwent bronchoalveolar lavage five times. The recovered fluid had high concentrations of interleukin-8 (IL-8), with a maximum of 6260 pg/ml and a minimum of 190 pg/ml, and these values correlated with the number of polymorphonuclear cells in the fluid. Levels of leukotriene B4, another chemotactic factor for PMN, in the lavage fluid were not high. We conclude that IL-8 was a major chemoattractant for PMN in the alveoli of this patient.

Original languageEnglish
Pages (from-to)552-556
Number of pages5
JournalJapanese Journal of Thoracic Diseases
Volume34
Issue number5
Publication statusPublished - 1996

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Chemotactic Factors
Adult Respiratory Distress Syndrome
Bronchoalveolar Lavage Fluid
Interleukin-8
Blood Gas Analysis
Leukotriene B4
Therapeutic Irrigation
Bronchoalveolar Lavage
Cough
Radiography
Dyspnea
Autopsy
Thorax
Heart Failure
Cell Count
Air
Tomography
Hypoxia

Keywords

  • Acute lung injury
  • Adult respiratory distress syndrome
  • Bronchoalveolar lavage
  • Interleukin-8
  • Neutrophil

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

High concentrations of interleukin-8 in bronchoalveolar lavage fluid from a patient with adult respiratory distress syndrome. / Matsubara, H.; Fujishima, Seitaro; Sayama, K.; Akasaka, Y.; Yamasawa, F.; Ishizaka, A.; Yamaguchi, K.; Kanazawa, M.

In: Japanese Journal of Thoracic Diseases, Vol. 34, No. 5, 1996, p. 552-556.

Research output: Contribution to journalArticle

Matsubara, H, Fujishima, S, Sayama, K, Akasaka, Y, Yamasawa, F, Ishizaka, A, Yamaguchi, K & Kanazawa, M 1996, 'High concentrations of interleukin-8 in bronchoalveolar lavage fluid from a patient with adult respiratory distress syndrome', Japanese Journal of Thoracic Diseases, vol. 34, no. 5, pp. 552-556.
Matsubara, H. ; Fujishima, Seitaro ; Sayama, K. ; Akasaka, Y. ; Yamasawa, F. ; Ishizaka, A. ; Yamaguchi, K. ; Kanazawa, M. / High concentrations of interleukin-8 in bronchoalveolar lavage fluid from a patient with adult respiratory distress syndrome. In: Japanese Journal of Thoracic Diseases. 1996 ; Vol. 34, No. 5. pp. 552-556.
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AU - Yamasawa, F.

AU - Ishizaka, A.

AU - Yamaguchi, K.

AU - Kanazawa, M.

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