High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men

SESSA Research group

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This study examines the associations of HDL-P and HDL-C with carotid intima-media thickness (cIMT) and plaque counts among Japanese men, who characteristically have higher HDL-C levels and a lower CHD burden than those in men of Western populations. Methods: We cross-sectionally examined a community-based sample of 870 Japanese men aged 40-79 years, free of known clinical cardiovascular disease (CVD) and not on lipid-lowering medication. Participants were randomly selected among Japanese living in Kusatsu City in Shiga, Japan. Results: Both HDL-P and HDL-C were inversely and independently associated with cIMT in models adjusted for conventional CHD risk factors, including low-density lipoprotein cholesterol (LDL-C) and diabetes. HDL-P maintained an association with cIMT after further adjustment for HDL-C (P<0.01), whereas the association of HDL-C with cIMT was noticeably absent after inclusion of HDL-P in the model. In plaque counts of the carotid arteries, HDL-P was significantly associated with a reduction in plaque count, whereas HDL-C was not. Conclusion: HDL-P, in comparison to HDL-C, is more strongly associated with measures of carotid atherosclerosis in a cross-sectional study of Japanese men. Findings demonstrate that, HDL-P is a strong correlate of subclinical atherosclerosis even in a population at low risk for CHD.

Original languageEnglish
Pages (from-to)444-450
Number of pages7
JournalAtherosclerosis
Volume239
Issue number2
DOIs
Publication statusPublished - 2015 Apr 1

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HDL Lipoproteins
Carotid Arteries
HDL Cholesterol
Atherosclerosis
Carotid Intima-Media Thickness
Coronary Disease
Carotid Artery Diseases
Carotid Stenosis
Hypercholesterolemia
LDL Cholesterol
Japan
Cardiovascular Diseases
Cross-Sectional Studies
Lipids
Population

Keywords

  • Carotid intima-media thickness (cIMT)
  • High-density lipoprotein (HDL) cholesterol
  • High-density lipoprotein (HDL) particle
  • Plaque count
  • Subclinical atherosclerosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men. / SESSA Research group.

In: Atherosclerosis, Vol. 239, No. 2, 01.04.2015, p. 444-450.

Research output: Contribution to journalArticle

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title = "High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men",
abstract = "The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This study examines the associations of HDL-P and HDL-C with carotid intima-media thickness (cIMT) and plaque counts among Japanese men, who characteristically have higher HDL-C levels and a lower CHD burden than those in men of Western populations. Methods: We cross-sectionally examined a community-based sample of 870 Japanese men aged 40-79 years, free of known clinical cardiovascular disease (CVD) and not on lipid-lowering medication. Participants were randomly selected among Japanese living in Kusatsu City in Shiga, Japan. Results: Both HDL-P and HDL-C were inversely and independently associated with cIMT in models adjusted for conventional CHD risk factors, including low-density lipoprotein cholesterol (LDL-C) and diabetes. HDL-P maintained an association with cIMT after further adjustment for HDL-C (P<0.01), whereas the association of HDL-C with cIMT was noticeably absent after inclusion of HDL-P in the model. In plaque counts of the carotid arteries, HDL-P was significantly associated with a reduction in plaque count, whereas HDL-C was not. Conclusion: HDL-P, in comparison to HDL-C, is more strongly associated with measures of carotid atherosclerosis in a cross-sectional study of Japanese men. Findings demonstrate that, HDL-P is a strong correlate of subclinical atherosclerosis even in a population at low risk for CHD.",
keywords = "Carotid intima-media thickness (cIMT), High-density lipoprotein (HDL) cholesterol, High-density lipoprotein (HDL) particle, Plaque count, Subclinical atherosclerosis",
author = "{SESSA Research group} and Maryam Zaid and Akira Fujiyoshi and Katsuyuki Miura and Abbott, {Robert D.} and Tomonori Okamura and Naoyuki Takashima and Sayuki Torii and Yoshino Saito and Takashi Hisamatsu and Naoko Miyagawa and Takayoshi Ohkubo and Aya Kadota and Akira Sekikawa and Hiroshi Maegawa and Yasuyuki Nakamura and Kenichi Mitsunami and Hirotsugu Ueshima and Minoru Horie and Yasutaka Nakano and Takashi Yamamoto and Emiko Ogawa and Itsuko Miyazawa and Kiyoshi Murata and Kazuhiko Nozaki and Akihiko Shiino and Isao Araki and Teruhiko Tsuru and Ikuo Toyama and Hisakazu Ogita and Souichi Kurita and Toshinaga Maeda and Naomi Miyamatsu and Toru Kita and Takeshi Kimura and Yoshihiko Nishio and Barinas-Mitchell, {Emma J M} and Daniel Edmundowicz and Atsushi Hozawa and Nagako Okuda and Aya Higashiyama and Shinya Nagasawa and Yoshikuni Kita and Takashi Kadowaki and Sayaka Kadowaki and Yoshitaka Murakami and Seiko Ohno",
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AU - SESSA Research group

AU - Zaid, Maryam

AU - Fujiyoshi, Akira

AU - Miura, Katsuyuki

AU - Abbott, Robert D.

AU - Okamura, Tomonori

AU - Takashima, Naoyuki

AU - Torii, Sayuki

AU - Saito, Yoshino

AU - Hisamatsu, Takashi

AU - Miyagawa, Naoko

AU - Ohkubo, Takayoshi

AU - Kadota, Aya

AU - Sekikawa, Akira

AU - Maegawa, Hiroshi

AU - Nakamura, Yasuyuki

AU - Mitsunami, Kenichi

AU - Ueshima, Hirotsugu

AU - Horie, Minoru

AU - Nakano, Yasutaka

AU - Yamamoto, Takashi

AU - Ogawa, Emiko

AU - Miyazawa, Itsuko

AU - Murata, Kiyoshi

AU - Nozaki, Kazuhiko

AU - Shiino, Akihiko

AU - Araki, Isao

AU - Tsuru, Teruhiko

AU - Toyama, Ikuo

AU - Ogita, Hisakazu

AU - Kurita, Souichi

AU - Maeda, Toshinaga

AU - Miyamatsu, Naomi

AU - Kita, Toru

AU - Kimura, Takeshi

AU - Nishio, Yoshihiko

AU - Barinas-Mitchell, Emma J M

AU - Edmundowicz, Daniel

AU - Hozawa, Atsushi

AU - Okuda, Nagako

AU - Higashiyama, Aya

AU - Nagasawa, Shinya

AU - Kita, Yoshikuni

AU - Kadowaki, Takashi

AU - Kadowaki, Sayaka

AU - Murakami, Yoshitaka

AU - Ohno, Seiko

PY - 2015/4/1

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N2 - The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This study examines the associations of HDL-P and HDL-C with carotid intima-media thickness (cIMT) and plaque counts among Japanese men, who characteristically have higher HDL-C levels and a lower CHD burden than those in men of Western populations. Methods: We cross-sectionally examined a community-based sample of 870 Japanese men aged 40-79 years, free of known clinical cardiovascular disease (CVD) and not on lipid-lowering medication. Participants were randomly selected among Japanese living in Kusatsu City in Shiga, Japan. Results: Both HDL-P and HDL-C were inversely and independently associated with cIMT in models adjusted for conventional CHD risk factors, including low-density lipoprotein cholesterol (LDL-C) and diabetes. HDL-P maintained an association with cIMT after further adjustment for HDL-C (P<0.01), whereas the association of HDL-C with cIMT was noticeably absent after inclusion of HDL-P in the model. In plaque counts of the carotid arteries, HDL-P was significantly associated with a reduction in plaque count, whereas HDL-C was not. Conclusion: HDL-P, in comparison to HDL-C, is more strongly associated with measures of carotid atherosclerosis in a cross-sectional study of Japanese men. Findings demonstrate that, HDL-P is a strong correlate of subclinical atherosclerosis even in a population at low risk for CHD.

AB - The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This study examines the associations of HDL-P and HDL-C with carotid intima-media thickness (cIMT) and plaque counts among Japanese men, who characteristically have higher HDL-C levels and a lower CHD burden than those in men of Western populations. Methods: We cross-sectionally examined a community-based sample of 870 Japanese men aged 40-79 years, free of known clinical cardiovascular disease (CVD) and not on lipid-lowering medication. Participants were randomly selected among Japanese living in Kusatsu City in Shiga, Japan. Results: Both HDL-P and HDL-C were inversely and independently associated with cIMT in models adjusted for conventional CHD risk factors, including low-density lipoprotein cholesterol (LDL-C) and diabetes. HDL-P maintained an association with cIMT after further adjustment for HDL-C (P<0.01), whereas the association of HDL-C with cIMT was noticeably absent after inclusion of HDL-P in the model. In plaque counts of the carotid arteries, HDL-P was significantly associated with a reduction in plaque count, whereas HDL-C was not. Conclusion: HDL-P, in comparison to HDL-C, is more strongly associated with measures of carotid atherosclerosis in a cross-sectional study of Japanese men. Findings demonstrate that, HDL-P is a strong correlate of subclinical atherosclerosis even in a population at low risk for CHD.

KW - Carotid intima-media thickness (cIMT)

KW - High-density lipoprotein (HDL) cholesterol

KW - High-density lipoprotein (HDL) particle

KW - Plaque count

KW - Subclinical atherosclerosis

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