High-dose chemotherapy and autologous peripheral blood stem cell transplantation in high-risk multiple myeloma

Hirokazu Murakami, Hiroshi Fujii, Tohru Inaba, Chihiro Shimazaki, Sinichirou Okamoto, Akiyosi Miwa, Morio Sawamura, Masahiro Abe, Takaaki Chou, Hideki Asaoku, Yoshikazu Kitahara, Kunihiko Hayashi, Masaaki Kosaka, Atsushi Togawa, Kiyoshi Takatsuki

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Abstract

We compared the effect of high-dose therapy together with autologous peripheral blood stem cell transplantation (autoPBSCT) in 60 patients with multiple myeloma (MM) with 90 patients who underwent conventional chemotherapy. We scored the prognostic factors according to our reported classification system that includes measurements of serum albumin, serum beta-2-microglobulin, and morphology of myeloma cells selected by multivariate analysis. We separated the patients into three risk groups at stratification level I (low, intermediate and high) and into two risk groups at stratification level II (low and high). AutoPBSCT tended to be as effective for high, as for low-risk patients in level I, and was obviously as helpful for high, as for low-risk patients in stratification II. In conclusion, high-risk patients with MM should be treated with high-dose therapy accompanied with autoPBSCT like low-risk patients.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalEuropean Journal of Haematology
Volume73
Issue number3
DOIs
Publication statusPublished - 2004 Sep

Keywords

  • Morphology
  • Myeloma
  • Prognostic factor
  • Stem cell transplantation
  • Stratification

ASJC Scopus subject areas

  • Hematology

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    Murakami, H., Fujii, H., Inaba, T., Shimazaki, C., Okamoto, S., Miwa, A., Sawamura, M., Abe, M., Chou, T., Asaoku, H., Kitahara, Y., Hayashi, K., Kosaka, M., Togawa, A., & Takatsuki, K. (2004). High-dose chemotherapy and autologous peripheral blood stem cell transplantation in high-risk multiple myeloma. European Journal of Haematology, 73(3), 169-173. https://doi.org/10.1111/j.1600-0609.2004.00282.x