High-dose dexamethasone may prevent esophageal stricture after endoscopic submucosal dissection

Satoshi Ono, Mitsuhiro Fujishiro, Shinya Kodashima, Chihiro Minatsuki, Kousuke Hirano, Keiko Niimi, Osamu Goto, Nobutake Yamamichi, Takashi Fukuda, Yasuyuki Seto, Kazuhiko Koike

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We report a rare case of esophageal endoscopic submucosal dissection (ESD) in a patient who underwent high-dose dexamethasone therapy for multiple myeloma shortly after ESD. A 61-year-old male was referred for treatment of esophageal superficial squamous cell carcinoma and underwent curative ESD. During his hospitalization for ESD, further examination for worsening back pain and gait disorder revealed multiple myeloma with multiple bone metastases. Consequently, high-dose dexamethasone therapy (40 mg × 4 days × 3 courses) was started on the 9th day after ESD. He was successfully treated by the subsequent peripheral blood stem cell transplantation. In the follow-up endoscopies, the artificial ulcer was shown to have re-epithelialized gradually with little or no size reduction of the ulcer bed. Minimal deformation of the lumen was observed. Histopathological assessment after surgical resection at a later date revealed thinned submucosa with minimal fibrosis of the ESD scar. This case demonstrated the effect of dexamethasone on the healing process of the artificial ulcer. Dexamethasone can be potentially useful for prevention of postoperative stricture, which is a major complication of esophageal ESD.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalClinical Journal of Gastroenterology
Volume3
Issue number3
DOIs
Publication statusPublished - 2010 Jun
Externally publishedYes

Fingerprint

Esophageal Stenosis
Dexamethasone
Multiple Myeloma
Ulcer
Peripheral Blood Stem Cell Transplantation
Somatoform Disorders
Back Pain
Endoscopic Mucosal Resection
Gait
Endoscopy
Cicatrix
Pathologic Constriction
Hospitalization
Fibrosis
Therapeutics
Neoplasm Metastasis
Bone and Bones

Keywords

  • ESD
  • Esophagus
  • Steroid
  • Stricture

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ono, S., Fujishiro, M., Kodashima, S., Minatsuki, C., Hirano, K., Niimi, K., ... Koike, K. (2010). High-dose dexamethasone may prevent esophageal stricture after endoscopic submucosal dissection. Clinical Journal of Gastroenterology, 3(3), 155-158. https://doi.org/10.1007/s12328-010-0147-z

High-dose dexamethasone may prevent esophageal stricture after endoscopic submucosal dissection. / Ono, Satoshi; Fujishiro, Mitsuhiro; Kodashima, Shinya; Minatsuki, Chihiro; Hirano, Kousuke; Niimi, Keiko; Goto, Osamu; Yamamichi, Nobutake; Fukuda, Takashi; Seto, Yasuyuki; Koike, Kazuhiko.

In: Clinical Journal of Gastroenterology, Vol. 3, No. 3, 06.2010, p. 155-158.

Research output: Contribution to journalArticle

Ono, S, Fujishiro, M, Kodashima, S, Minatsuki, C, Hirano, K, Niimi, K, Goto, O, Yamamichi, N, Fukuda, T, Seto, Y & Koike, K 2010, 'High-dose dexamethasone may prevent esophageal stricture after endoscopic submucosal dissection', Clinical Journal of Gastroenterology, vol. 3, no. 3, pp. 155-158. https://doi.org/10.1007/s12328-010-0147-z
Ono, Satoshi ; Fujishiro, Mitsuhiro ; Kodashima, Shinya ; Minatsuki, Chihiro ; Hirano, Kousuke ; Niimi, Keiko ; Goto, Osamu ; Yamamichi, Nobutake ; Fukuda, Takashi ; Seto, Yasuyuki ; Koike, Kazuhiko. / High-dose dexamethasone may prevent esophageal stricture after endoscopic submucosal dissection. In: Clinical Journal of Gastroenterology. 2010 ; Vol. 3, No. 3. pp. 155-158.
@article{2e9800eb58184bbc8a6490a1099e9e85,
title = "High-dose dexamethasone may prevent esophageal stricture after endoscopic submucosal dissection",
abstract = "We report a rare case of esophageal endoscopic submucosal dissection (ESD) in a patient who underwent high-dose dexamethasone therapy for multiple myeloma shortly after ESD. A 61-year-old male was referred for treatment of esophageal superficial squamous cell carcinoma and underwent curative ESD. During his hospitalization for ESD, further examination for worsening back pain and gait disorder revealed multiple myeloma with multiple bone metastases. Consequently, high-dose dexamethasone therapy (40 mg × 4 days × 3 courses) was started on the 9th day after ESD. He was successfully treated by the subsequent peripheral blood stem cell transplantation. In the follow-up endoscopies, the artificial ulcer was shown to have re-epithelialized gradually with little or no size reduction of the ulcer bed. Minimal deformation of the lumen was observed. Histopathological assessment after surgical resection at a later date revealed thinned submucosa with minimal fibrosis of the ESD scar. This case demonstrated the effect of dexamethasone on the healing process of the artificial ulcer. Dexamethasone can be potentially useful for prevention of postoperative stricture, which is a major complication of esophageal ESD.",
keywords = "ESD, Esophagus, Steroid, Stricture",
author = "Satoshi Ono and Mitsuhiro Fujishiro and Shinya Kodashima and Chihiro Minatsuki and Kousuke Hirano and Keiko Niimi and Osamu Goto and Nobutake Yamamichi and Takashi Fukuda and Yasuyuki Seto and Kazuhiko Koike",
year = "2010",
month = "6",
doi = "10.1007/s12328-010-0147-z",
language = "English",
volume = "3",
pages = "155--158",
journal = "Clinical Journal of Gastroenterology",
issn = "1865-7257",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - High-dose dexamethasone may prevent esophageal stricture after endoscopic submucosal dissection

AU - Ono, Satoshi

AU - Fujishiro, Mitsuhiro

AU - Kodashima, Shinya

AU - Minatsuki, Chihiro

AU - Hirano, Kousuke

AU - Niimi, Keiko

AU - Goto, Osamu

AU - Yamamichi, Nobutake

AU - Fukuda, Takashi

AU - Seto, Yasuyuki

AU - Koike, Kazuhiko

PY - 2010/6

Y1 - 2010/6

N2 - We report a rare case of esophageal endoscopic submucosal dissection (ESD) in a patient who underwent high-dose dexamethasone therapy for multiple myeloma shortly after ESD. A 61-year-old male was referred for treatment of esophageal superficial squamous cell carcinoma and underwent curative ESD. During his hospitalization for ESD, further examination for worsening back pain and gait disorder revealed multiple myeloma with multiple bone metastases. Consequently, high-dose dexamethasone therapy (40 mg × 4 days × 3 courses) was started on the 9th day after ESD. He was successfully treated by the subsequent peripheral blood stem cell transplantation. In the follow-up endoscopies, the artificial ulcer was shown to have re-epithelialized gradually with little or no size reduction of the ulcer bed. Minimal deformation of the lumen was observed. Histopathological assessment after surgical resection at a later date revealed thinned submucosa with minimal fibrosis of the ESD scar. This case demonstrated the effect of dexamethasone on the healing process of the artificial ulcer. Dexamethasone can be potentially useful for prevention of postoperative stricture, which is a major complication of esophageal ESD.

AB - We report a rare case of esophageal endoscopic submucosal dissection (ESD) in a patient who underwent high-dose dexamethasone therapy for multiple myeloma shortly after ESD. A 61-year-old male was referred for treatment of esophageal superficial squamous cell carcinoma and underwent curative ESD. During his hospitalization for ESD, further examination for worsening back pain and gait disorder revealed multiple myeloma with multiple bone metastases. Consequently, high-dose dexamethasone therapy (40 mg × 4 days × 3 courses) was started on the 9th day after ESD. He was successfully treated by the subsequent peripheral blood stem cell transplantation. In the follow-up endoscopies, the artificial ulcer was shown to have re-epithelialized gradually with little or no size reduction of the ulcer bed. Minimal deformation of the lumen was observed. Histopathological assessment after surgical resection at a later date revealed thinned submucosa with minimal fibrosis of the ESD scar. This case demonstrated the effect of dexamethasone on the healing process of the artificial ulcer. Dexamethasone can be potentially useful for prevention of postoperative stricture, which is a major complication of esophageal ESD.

KW - ESD

KW - Esophagus

KW - Steroid

KW - Stricture

UR - http://www.scopus.com/inward/record.url?scp=77955665303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955665303&partnerID=8YFLogxK

U2 - 10.1007/s12328-010-0147-z

DO - 10.1007/s12328-010-0147-z

M3 - Article

VL - 3

SP - 155

EP - 158

JO - Clinical Journal of Gastroenterology

JF - Clinical Journal of Gastroenterology

SN - 1865-7257

IS - 3

ER -