High frequency of Vα24+ Vβ11+ T-cells observed in type 1 diabetes

Yoichi Oikawa, Akira Shimada, Satoru Yamada, Yoshiko Motohashi, Yoshinori Nakagawa, Junichiro Irie, Taro Maruyama, Takao Saruta

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Abstract

OBJECTIVE - Natural killer T-cells (NKT cells) are believed to play an important role in the regulation of immune response, and a numerical and functional deficit of NKT cells has been reported to be associated with the pathogenesis of autoimmune diseases. Thus far, it has been shown that subjects with type 1 diabetes have a lower frequency of NKT cells than nondiabetic subjects. In this study, we measured the frequency of peripheral Vα24 + Vβ11+ T-cells, which include human NKT cells, in Japanese diabetic patients. RESEARCH DESIGN AND METHODS - Peripheral blood samples were obtained from 164 Japanese diabetic patients and 67 healthy subjects. The diabetic patients were classified into four categories as follows: islet-associated autoantibody-positive (Ab+) and -negative (Ab -) classic type 1 diabetes, latent autoimmune diabetes in adults (LADA), and type 2 diabetes. We measured the frequency of peripheral Vα24+ Vβ11+ CD3+ triple-positive cells. RESULTS - Unexpectedly, a higher frequency of Vα24+ Vβ11+ T-cells was observed in Ab+ and Ab- patients compared with LADA patients (P = 0.0294 and P = 0.0021), type 2 diabetic patients (P < 0.0001 and P < 0.0001), and healthy subjects (P = 0.0046 and P = 0.0001). Moreover, an inverse correlation between Vα24 + Vβ11+ T-cell frequency and disease duration was observed in Ab+ (p = -0.455; P = 0.0023) and Ab- (p = -0.432; P = 0.0162) patients. CONCLUSIONS - Our findings indicate that a high frequency of Vα24+ Vβ11+ T-cells is a unique finding in recent-onset classic type 1 diabetes, and measurement of Vα24+ Vβ11+ T-cell frequency may be useful to assess the disease activity of classic type 1 diabetes.

Original languageEnglish
Pages (from-to)1818-1823
Number of pages6
JournalDiabetes Care
Volume25
Issue number10
DOIs
Publication statusPublished - 2002 Oct

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Type 1 Diabetes Mellitus
Natural Killer T-Cells
T-Lymphocytes
Healthy Volunteers
Autoantibodies
Type 2 Diabetes Mellitus
Autoimmune Diseases
Research Design

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Oikawa, Y., Shimada, A., Yamada, S., Motohashi, Y., Nakagawa, Y., Irie, J., ... Saruta, T. (2002). High frequency of Vα24+ Vβ11+ T-cells observed in type 1 diabetes. Diabetes Care, 25(10), 1818-1823. https://doi.org/10.2337/diacare.25.10.1818

High frequency of Vα24+ Vβ11+ T-cells observed in type 1 diabetes. / Oikawa, Yoichi; Shimada, Akira; Yamada, Satoru; Motohashi, Yoshiko; Nakagawa, Yoshinori; Irie, Junichiro; Maruyama, Taro; Saruta, Takao.

In: Diabetes Care, Vol. 25, No. 10, 10.2002, p. 1818-1823.

Research output: Contribution to journalArticle

Oikawa, Y, Shimada, A, Yamada, S, Motohashi, Y, Nakagawa, Y, Irie, J, Maruyama, T & Saruta, T 2002, 'High frequency of Vα24+ Vβ11+ T-cells observed in type 1 diabetes', Diabetes Care, vol. 25, no. 10, pp. 1818-1823. https://doi.org/10.2337/diacare.25.10.1818
Oikawa Y, Shimada A, Yamada S, Motohashi Y, Nakagawa Y, Irie J et al. High frequency of Vα24+ Vβ11+ T-cells observed in type 1 diabetes. Diabetes Care. 2002 Oct;25(10):1818-1823. https://doi.org/10.2337/diacare.25.10.1818
Oikawa, Yoichi ; Shimada, Akira ; Yamada, Satoru ; Motohashi, Yoshiko ; Nakagawa, Yoshinori ; Irie, Junichiro ; Maruyama, Taro ; Saruta, Takao. / High frequency of Vα24+ Vβ11+ T-cells observed in type 1 diabetes. In: Diabetes Care. 2002 ; Vol. 25, No. 10. pp. 1818-1823.
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AU - Irie, Junichiro

AU - Maruyama, Taro

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