Abstract
OBJECTIVE - Natural killer T-cells (NKT cells) are believed to play an important role in the regulation of immune response, and a numerical and functional deficit of NKT cells has been reported to be associated with the pathogenesis of autoimmune diseases. Thus far, it has been shown that subjects with type 1 diabetes have a lower frequency of NKT cells than nondiabetic subjects. In this study, we measured the frequency of peripheral Vα24 + Vβ11+ T-cells, which include human NKT cells, in Japanese diabetic patients. RESEARCH DESIGN AND METHODS - Peripheral blood samples were obtained from 164 Japanese diabetic patients and 67 healthy subjects. The diabetic patients were classified into four categories as follows: islet-associated autoantibody-positive (Ab+) and -negative (Ab -) classic type 1 diabetes, latent autoimmune diabetes in adults (LADA), and type 2 diabetes. We measured the frequency of peripheral Vα24+ Vβ11+ CD3+ triple-positive cells. RESULTS - Unexpectedly, a higher frequency of Vα24+ Vβ11+ T-cells was observed in Ab+ and Ab- patients compared with LADA patients (P = 0.0294 and P = 0.0021), type 2 diabetic patients (P < 0.0001 and P < 0.0001), and healthy subjects (P = 0.0046 and P = 0.0001). Moreover, an inverse correlation between Vα24 + Vβ11+ T-cell frequency and disease duration was observed in Ab+ (p = -0.455; P = 0.0023) and Ab- (p = -0.432; P = 0.0162) patients. CONCLUSIONS - Our findings indicate that a high frequency of Vα24+ Vβ11+ T-cells is a unique finding in recent-onset classic type 1 diabetes, and measurement of Vα24+ Vβ11+ T-cell frequency may be useful to assess the disease activity of classic type 1 diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 1818-1823 |
| Number of pages | 6 |
| Journal | Diabetes Care |
| Volume | 25 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2002 Oct |
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ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
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High frequency of Vα24+ Vβ11+ T-cells observed in type 1 diabetes. / Oikawa, Yoichi; Shimada, Akira; Yamada, Satoru; Motohashi, Yoshiko; Nakagawa, Yoshinori; Irie, Junichiro; Maruyama, Taro; Saruta, Takao.
In: Diabetes Care, Vol. 25, No. 10, 10.2002, p. 1818-1823.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High frequency of Vα24+ Vβ11+ T-cells observed in type 1 diabetes
AU - Oikawa, Yoichi
AU - Shimada, Akira
AU - Yamada, Satoru
AU - Motohashi, Yoshiko
AU - Nakagawa, Yoshinori
AU - Irie, Junichiro
AU - Maruyama, Taro
AU - Saruta, Takao
PY - 2002/10
Y1 - 2002/10
N2 - OBJECTIVE - Natural killer T-cells (NKT cells) are believed to play an important role in the regulation of immune response, and a numerical and functional deficit of NKT cells has been reported to be associated with the pathogenesis of autoimmune diseases. Thus far, it has been shown that subjects with type 1 diabetes have a lower frequency of NKT cells than nondiabetic subjects. In this study, we measured the frequency of peripheral Vα24 + Vβ11+ T-cells, which include human NKT cells, in Japanese diabetic patients. RESEARCH DESIGN AND METHODS - Peripheral blood samples were obtained from 164 Japanese diabetic patients and 67 healthy subjects. The diabetic patients were classified into four categories as follows: islet-associated autoantibody-positive (Ab+) and -negative (Ab -) classic type 1 diabetes, latent autoimmune diabetes in adults (LADA), and type 2 diabetes. We measured the frequency of peripheral Vα24+ Vβ11+ CD3+ triple-positive cells. RESULTS - Unexpectedly, a higher frequency of Vα24+ Vβ11+ T-cells was observed in Ab+ and Ab- patients compared with LADA patients (P = 0.0294 and P = 0.0021), type 2 diabetic patients (P < 0.0001 and P < 0.0001), and healthy subjects (P = 0.0046 and P = 0.0001). Moreover, an inverse correlation between Vα24 + Vβ11+ T-cell frequency and disease duration was observed in Ab+ (p = -0.455; P = 0.0023) and Ab- (p = -0.432; P = 0.0162) patients. CONCLUSIONS - Our findings indicate that a high frequency of Vα24+ Vβ11+ T-cells is a unique finding in recent-onset classic type 1 diabetes, and measurement of Vα24+ Vβ11+ T-cell frequency may be useful to assess the disease activity of classic type 1 diabetes.
AB - OBJECTIVE - Natural killer T-cells (NKT cells) are believed to play an important role in the regulation of immune response, and a numerical and functional deficit of NKT cells has been reported to be associated with the pathogenesis of autoimmune diseases. Thus far, it has been shown that subjects with type 1 diabetes have a lower frequency of NKT cells than nondiabetic subjects. In this study, we measured the frequency of peripheral Vα24 + Vβ11+ T-cells, which include human NKT cells, in Japanese diabetic patients. RESEARCH DESIGN AND METHODS - Peripheral blood samples were obtained from 164 Japanese diabetic patients and 67 healthy subjects. The diabetic patients were classified into four categories as follows: islet-associated autoantibody-positive (Ab+) and -negative (Ab -) classic type 1 diabetes, latent autoimmune diabetes in adults (LADA), and type 2 diabetes. We measured the frequency of peripheral Vα24+ Vβ11+ CD3+ triple-positive cells. RESULTS - Unexpectedly, a higher frequency of Vα24+ Vβ11+ T-cells was observed in Ab+ and Ab- patients compared with LADA patients (P = 0.0294 and P = 0.0021), type 2 diabetic patients (P < 0.0001 and P < 0.0001), and healthy subjects (P = 0.0046 and P = 0.0001). Moreover, an inverse correlation between Vα24 + Vβ11+ T-cell frequency and disease duration was observed in Ab+ (p = -0.455; P = 0.0023) and Ab- (p = -0.432; P = 0.0162) patients. CONCLUSIONS - Our findings indicate that a high frequency of Vα24+ Vβ11+ T-cells is a unique finding in recent-onset classic type 1 diabetes, and measurement of Vα24+ Vβ11+ T-cell frequency may be useful to assess the disease activity of classic type 1 diabetes.
UR - http://www.scopus.com/inward/record.url?scp=0036782361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036782361&partnerID=8YFLogxK
U2 - 10.2337/diacare.25.10.1818
DO - 10.2337/diacare.25.10.1818
M3 - Article
C2 - 12351484
AN - SCOPUS:0036782361
VL - 25
SP - 1818
EP - 1823
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 10
ER -