High-grade dysplasia associated with fundic gland polyposis in a familial adenomatous polyposis patient, with special reference to APC mutation profiles

Shigeki Sekine, Tadakazu Shimoda, Satoshi Nimura, Yukihiro Nakanishi, Takayuki Akasu, Hitoshi Katai, Takuji Gotoda, Tatsuhiro Shibata, Michiie Sakamoto, Setsuo Hirohashi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We report a patient with familial adenomatous polyposis who developed high-grade dysplasia against a background of fundic gland polyposis. Two large high-grade dysplasia lesions were found in the gastric body, where numerous fundic gland polyps were present. In both lesions, the dysplastic epithelium covered non-neoplastic oxyntic glands that occasionally exhibit cystic changes. A genetic analysis for APC (adenomatous polyposis coli) revealed a somatic 50-bp deletion involving codons 1502-1517 and 2-bp deletion at codon 1465 in each lesion of high-grade dysplasia. In contrast, six of the 18 fundic gland polyps were found to harbor an identical mutation: 1-bp insertion at codon 1556. Both lesions of high-grade dysplasia and the fundic gland polyps were similarly located in the fundic gland area and were caused by the inactivaticn of APC; however, their mutation profiles of APC were different. These results imply that fundic gland polyps and high-grade dysplasia of the stomach have distinct preferences for APC genotypes in their development.

Original languageEnglish
Pages (from-to)1421-1426
Number of pages6
JournalModern Pathology
Volume17
Issue number11
DOIs
Publication statusPublished - 2004 Nov 1

Keywords

  • APC
  • Familial adenomatous polyposis
  • Gastric dysplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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