High-grade trichoblastic carcinoma arising through malignant transformation of trichoblastoma

Immunohistochemical analysis and the expression of p53 and phosphorylated AKT

Takayuki Fusumae, Keiji Tanese, Asako Takeuchi, Arisa Takasugi, Rino Kawakita, Junichi Shiraishi, Tetsuya Yoshida

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Trichoblastoma (TB) is a benign cutaneous adnexal neoplasm. The lesion typically presents as a slow-growing, solitary, well-circumscribed nodule measuring up to 3 cm in diameter. On rare occasions, TB causes malignant transformation into an aggressive form described as high-grade trichoblastic carcinoma. Four such cases have been reported to date; all were described as high-grade trichoblastic carcinomas. Here, we describe the case of a 72-year-old Japanese male patient with a rapidly enlarging subcutaneous tumor on his lower back, which was diagnosed as high-grade trichoblastic carcinoma. Histopathologically, the tumor featured both benign and malignant components, and a transition zone between these states was clearly evident. In the immunohistochemical analysis, a malignant component was positive for p53 and showed stronger staining of phospho-RAC-α serine/threonine-protein kinase (AKT) Ser473 in comparison with a benign component. These results suggest that loss of p53 function and activation of phosphatidylinositol 3-kinase–AKT signaling pathways played important pathogenic roles in malignant transformation of the present case.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalJournal of Dermatology
Volume46
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

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Carcinoma
Protein-Serine-Threonine Kinases
Skin Neoplasms
Phosphatidylinositols
Neoplasms
Staining and Labeling

Keywords

  • AKT
  • high-grade trichoblastic carcinoma
  • malignant transformation
  • p53
  • trichoblastoma

ASJC Scopus subject areas

  • Dermatology

Cite this

High-grade trichoblastic carcinoma arising through malignant transformation of trichoblastoma : Immunohistochemical analysis and the expression of p53 and phosphorylated AKT. / Fusumae, Takayuki; Tanese, Keiji; Takeuchi, Asako; Takasugi, Arisa; Kawakita, Rino; Shiraishi, Junichi; Yoshida, Tetsuya.

In: Journal of Dermatology, Vol. 46, No. 1, 01.01.2019, p. 57-60.

Research output: Contribution to journalArticle

Fusumae, Takayuki ; Tanese, Keiji ; Takeuchi, Asako ; Takasugi, Arisa ; Kawakita, Rino ; Shiraishi, Junichi ; Yoshida, Tetsuya. / High-grade trichoblastic carcinoma arising through malignant transformation of trichoblastoma : Immunohistochemical analysis and the expression of p53 and phosphorylated AKT. In: Journal of Dermatology. 2019 ; Vol. 46, No. 1. pp. 57-60.
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