High impact of FDG-PET/CT in diagnostic strategies for ovarian cancer

Ashraf Anas Zytoon, Koji Murakami, Hazem Eid, Mahmoud El-Gammal

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Ovarian cancer has the highest mortality of all gynecologic malignancies. FDG-PET/CT was proven to be accurate for identification of primary ovarian tumors, regional lymph nodes, and distant metastases. Purpose: To evaluate ovarian masses at FDG-PET/CT in correlation with histopathologic findings. Material and Methods: Ninety-eight patients underwent whole body FDG-PET/CT examination. Eighty-six patients with primary ovarian cancer and 12 patients with metastatic disease to the ovaries were included. Results: PET/CT imaging was true-positive in 87/94 patients with malignant tumors. In 4/4 patients with benign tumors, PET/CT results were true-negative, with sensitivity of 92.6%, specificity 100%, total test accuracy 92.9%. Fifty-seven patients were diagnosed as stage IV ovarian cancer with distant metastasis. Conclusion: The anatomical/functional examination by FDG-PET/CT was proven to be valuable in increasing the diagnostic accuracy that can help improve patient management.

Original languageEnglish
Pages (from-to)340-348
Number of pages9
JournalActa Radiologica
Volume54
Issue number3
DOIs
Publication statusPublished - 2013 Apr

Keywords

  • FDG
  • Ovarian cancer
  • PET-CT

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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    Zytoon, A. A., Murakami, K., Eid, H., & El-Gammal, M. (2013). High impact of FDG-PET/CT in diagnostic strategies for ovarian cancer. Acta Radiologica, 54(3), 340-348. https://doi.org/10.1258/ar.2012.120632