High-mobility-group box chromosomal protein 1 as a new target for modulating stress response

Koichi Suda, Hiroya Takeuchi, Akitoshi Ishizaka, Yuko Kitagawa

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Major surgical procedures induce a systemic inflammatory response syndrome (SIRS) characterized by the overproduction of proinflammatory cytokines, which induces excessive stress and may trigger postoperative complications. This has prompted the hypothesis that drugs which relieve SIRS might improve the postoperative course of major surgery. One of the most promising targets for these drugs is high-mobility-group box chromosomal protein 1 (HMGB1). In 1999, HMGB1 was found to be a key late mediator of sepsis. It is now known to be associated with various kinds of acute and chronic inflammation, and is recognized as one of the most important danger signals in stress response. In this article, we present the latest information about HMGB1 and discuss its promise as a novel target for modulating stress response.

Original languageEnglish
Pages (from-to)592-601
Number of pages10
JournalSurgery today
Volume40
Issue number7
DOIs
Publication statusPublished - 2010 Jul 1

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Keywords

  • Alarmin
  • High-mobility-group box chromosomal protein 1
  • Multiple organ dysfunction syndrome
  • Pathogen-associated molecular pattern
  • Stress response
  • Systemic inflammatory response syndrome

ASJC Scopus subject areas

  • Surgery

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