High oxygen breathing improves inhomogeneities of ventilation-perfusion distributions in acutely injured lungs

K. Yamaguchi, Masaaki Mori, T. Takashugi, Y. Oyamada, A. Kawai, K. Asano, T. Aoki, H. Fujita, Y. Suzuki

Research output: Contribution to journalArticle

Abstract

Using twenty-five mongrel dogs either with or without alveolar flooding induced by oleic acid administration, the effects of high oxygen breathing (60% O2) on ventilation-perfusion (V̇(A)/Q̇) distributions in the lungs were systematically investigated. V̇(A)/Q̇ distributions were examined by multiple inert gas elimination technique, from which the V̇(A)/Q̇ values describing mean positions of perfusion (Q̇) and ventilation (V̇(A)) distributions against the V̇(A)/Q̇ axis were calculated (mean Q̇ and mean V̇(A)). As the first measure of dispersion for V̇(A)/Q̇ distribution, the log standard deviation was estimated (log SD (Q̇) and log SD (V̇(A))). As the second measure of dispersion, the area under the curve, constructed by plotting inert gas arterial-to-alveolar partial pressure differences as a function of blood-gas partition coefficient, was calculated (aAD area). High oxygen breathing slightly enhanced the dispersion of V̇(A)/Q̇ distributions in the normal dogs but decreased that in the dogs injured with oleic acid. Therefore, we concluded that high oxygen breathing worsened the inhomogeneities of V̇(A)/Q̇ distributions in normal lungs but did improve those in acutely injured lungs.

Original languageEnglish
Pages (from-to)739-746
Number of pages8
JournalJapanese Journal of Thoracic Diseases
Volume32
Issue number8
Publication statusPublished - 1994

Fingerprint

Ventilation
Noble Gases
Respiration
Perfusion
Normal Distribution
Dogs
Oleic Acid
Oxygen
Lung
Partial Pressure
Area Under Curve
Gases

Keywords

  • acute lung injury
  • high oxygen breathing
  • multiple inert gas elimination
  • oleic acid
  • V̇(A)/Q̇ distribution

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Yamaguchi, K., Mori, M., Takashugi, T., Oyamada, Y., Kawai, A., Asano, K., ... Suzuki, Y. (1994). High oxygen breathing improves inhomogeneities of ventilation-perfusion distributions in acutely injured lungs. Japanese Journal of Thoracic Diseases, 32(8), 739-746.

High oxygen breathing improves inhomogeneities of ventilation-perfusion distributions in acutely injured lungs. / Yamaguchi, K.; Mori, Masaaki; Takashugi, T.; Oyamada, Y.; Kawai, A.; Asano, K.; Aoki, T.; Fujita, H.; Suzuki, Y.

In: Japanese Journal of Thoracic Diseases, Vol. 32, No. 8, 1994, p. 739-746.

Research output: Contribution to journalArticle

Yamaguchi, K, Mori, M, Takashugi, T, Oyamada, Y, Kawai, A, Asano, K, Aoki, T, Fujita, H & Suzuki, Y 1994, 'High oxygen breathing improves inhomogeneities of ventilation-perfusion distributions in acutely injured lungs', Japanese Journal of Thoracic Diseases, vol. 32, no. 8, pp. 739-746.
Yamaguchi, K. ; Mori, Masaaki ; Takashugi, T. ; Oyamada, Y. ; Kawai, A. ; Asano, K. ; Aoki, T. ; Fujita, H. ; Suzuki, Y. / High oxygen breathing improves inhomogeneities of ventilation-perfusion distributions in acutely injured lungs. In: Japanese Journal of Thoracic Diseases. 1994 ; Vol. 32, No. 8. pp. 739-746.
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