Abstract
Using twenty-five mongrel dogs either with or without alveolar flooding induced by oleic acid administration, the effects of high oxygen breathing (60% O2) on ventilation-perfusion (V̇(A)/Q̇) distributions in the lungs were systematically investigated. V̇(A)/Q̇ distributions were examined by multiple inert gas elimination technique, from which the V̇(A)/Q̇ values describing mean positions of perfusion (Q̇) and ventilation (V̇(A)) distributions against the V̇(A)/Q̇ axis were calculated (mean Q̇ and mean V̇(A)). As the first measure of dispersion for V̇(A)/Q̇ distribution, the log standard deviation was estimated (log SD (Q̇) and log SD (V̇(A))). As the second measure of dispersion, the area under the curve, constructed by plotting inert gas arterial-to-alveolar partial pressure differences as a function of blood-gas partition coefficient, was calculated (aAD area). High oxygen breathing slightly enhanced the dispersion of V̇(A)/Q̇ distributions in the normal dogs but decreased that in the dogs injured with oleic acid. Therefore, we concluded that high oxygen breathing worsened the inhomogeneities of V̇(A)/Q̇ distributions in normal lungs but did improve those in acutely injured lungs.
Original language | English |
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Pages (from-to) | 739-746 |
Number of pages | 8 |
Journal | Japanese Journal of Thoracic Diseases |
Volume | 32 |
Issue number | 8 |
Publication status | Published - 1994 Jan 1 |
Keywords
- V̇(A)/Q̇ distribution
- acute lung injury
- high oxygen breathing
- multiple inert gas elimination
- oleic acid
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine