Abstract
Using twenty-five mongrel dogs either with or without alveolar flooding induced by oleic acid administration, the effects of high oxygen breathing (60% O2) on ventilation-perfusion (V̇(A)/Q̇) distributions in the lungs were systematically investigated. V̇(A)/Q̇ distributions were examined by multiple inert gas elimination technique, from which the V̇(A)/Q̇ values describing mean positions of perfusion (Q̇) and ventilation (V̇(A)) distributions against the V̇(A)/Q̇ axis were calculated (mean Q̇ and mean V̇(A)). As the first measure of dispersion for V̇(A)/Q̇ distribution, the log standard deviation was estimated (log SD (Q̇) and log SD (V̇(A))). As the second measure of dispersion, the area under the curve, constructed by plotting inert gas arterial-to-alveolar partial pressure differences as a function of blood-gas partition coefficient, was calculated (aAD area). High oxygen breathing slightly enhanced the dispersion of V̇(A)/Q̇ distributions in the normal dogs but decreased that in the dogs injured with oleic acid. Therefore, we concluded that high oxygen breathing worsened the inhomogeneities of V̇(A)/Q̇ distributions in normal lungs but did improve those in acutely injured lungs.
| Original language | English |
|---|---|
| Pages (from-to) | 739-746 |
| Number of pages | 8 |
| Journal | Japanese Journal of Thoracic Diseases |
| Volume | 32 |
| Issue number | 8 |
| Publication status | Published - 1994 |
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Keywords
- acute lung injury
- high oxygen breathing
- multiple inert gas elimination
- oleic acid
- V̇(A)/Q̇ distribution
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
High oxygen breathing improves inhomogeneities of ventilation-perfusion distributions in acutely injured lungs. / Yamaguchi, K.; Mori, Masaaki; Takashugi, T.; Oyamada, Y.; Kawai, A.; Asano, K.; Aoki, T.; Fujita, H.; Suzuki, Y.
In: Japanese Journal of Thoracic Diseases, Vol. 32, No. 8, 1994, p. 739-746.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High oxygen breathing improves inhomogeneities of ventilation-perfusion distributions in acutely injured lungs
AU - Yamaguchi, K.
AU - Mori, Masaaki
AU - Takashugi, T.
AU - Oyamada, Y.
AU - Kawai, A.
AU - Asano, K.
AU - Aoki, T.
AU - Fujita, H.
AU - Suzuki, Y.
PY - 1994
Y1 - 1994
N2 - Using twenty-five mongrel dogs either with or without alveolar flooding induced by oleic acid administration, the effects of high oxygen breathing (60% O2) on ventilation-perfusion (V̇(A)/Q̇) distributions in the lungs were systematically investigated. V̇(A)/Q̇ distributions were examined by multiple inert gas elimination technique, from which the V̇(A)/Q̇ values describing mean positions of perfusion (Q̇) and ventilation (V̇(A)) distributions against the V̇(A)/Q̇ axis were calculated (mean Q̇ and mean V̇(A)). As the first measure of dispersion for V̇(A)/Q̇ distribution, the log standard deviation was estimated (log SD (Q̇) and log SD (V̇(A))). As the second measure of dispersion, the area under the curve, constructed by plotting inert gas arterial-to-alveolar partial pressure differences as a function of blood-gas partition coefficient, was calculated (aAD area). High oxygen breathing slightly enhanced the dispersion of V̇(A)/Q̇ distributions in the normal dogs but decreased that in the dogs injured with oleic acid. Therefore, we concluded that high oxygen breathing worsened the inhomogeneities of V̇(A)/Q̇ distributions in normal lungs but did improve those in acutely injured lungs.
AB - Using twenty-five mongrel dogs either with or without alveolar flooding induced by oleic acid administration, the effects of high oxygen breathing (60% O2) on ventilation-perfusion (V̇(A)/Q̇) distributions in the lungs were systematically investigated. V̇(A)/Q̇ distributions were examined by multiple inert gas elimination technique, from which the V̇(A)/Q̇ values describing mean positions of perfusion (Q̇) and ventilation (V̇(A)) distributions against the V̇(A)/Q̇ axis were calculated (mean Q̇ and mean V̇(A)). As the first measure of dispersion for V̇(A)/Q̇ distribution, the log standard deviation was estimated (log SD (Q̇) and log SD (V̇(A))). As the second measure of dispersion, the area under the curve, constructed by plotting inert gas arterial-to-alveolar partial pressure differences as a function of blood-gas partition coefficient, was calculated (aAD area). High oxygen breathing slightly enhanced the dispersion of V̇(A)/Q̇ distributions in the normal dogs but decreased that in the dogs injured with oleic acid. Therefore, we concluded that high oxygen breathing worsened the inhomogeneities of V̇(A)/Q̇ distributions in normal lungs but did improve those in acutely injured lungs.
KW - acute lung injury
KW - high oxygen breathing
KW - multiple inert gas elimination
KW - oleic acid
KW - V̇(A)/Q̇ distribution
UR - http://www.scopus.com/inward/record.url?scp=0027938048&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027938048&partnerID=8YFLogxK
M3 - Article
C2 - 7807752
AN - SCOPUS:0027938048
VL - 32
SP - 739
EP - 746
JO - Respiratory Investigation
JF - Respiratory Investigation
SN - 2212-5345
IS - 8
ER -