High-performance liquid chromatography of anti-pyretics on chemically modified porous glass

Yoshikazu Matsushima, Yoshiko Nagata, Keiko Takakusagi, Miki Niyomura, Nobuharu Takai

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

An octadecylsilyl porous glass was prepared and used as the packing for reversed-phase high-performance liquid chromatography. Five antipyretic drugs (aspirin, caffeine, guaiacol glycerol ether, 3-hydroxy-p-butyrophenetidine, and phenacetin) were separated in 2 min with a mobile phase of 20% acetonitrile at a flow-rate of 3.0 ml/min. A pharmaceutical preparation, containing aspirin, phenacetin, caffeine and chlorpheniramine maleate was analysed in 2 min with a mobile phase of acetonitrile-water-acetic acid (20:79:1). The packing seems promising for the rapid analysis of pharmaceuticals and biomedical compounds.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalJournal of Chromatography A
Volume332
Issue numberC
DOIs
Publication statusPublished - 1985 Sep 20

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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