High plasma adiponectin levels are associated with frailty in a general old-old population: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study

Motonori Nagasawa, Yoichi Takami, Hiroshi Akasaka, Mai Kabayama, Satomi Maeda, Serina Yokoyama, Taku Fujimoto, Yoichi Nozato, Yuki Imaizumi, Masao Takeda, Norihisa Itoh, Yasushi Takeya, Koichi Yamamoto, Ken Sugimoto, Takeshi Nakagawa, Yukie Masui, Yasumichi Arai, Tatsuro Ishizaki, Kazunori Ikebe, Yasuyuki GondoKei Kamide, Hiromi Rakugi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim: The objective of the present study was to investigate the association between frailty and plasma adiponectin levels in a general population of Japanese older adults. Methods: The volunteer older adults, aged approximately 83years, were recruited randomly from a general population in the Japanese Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. We used the modified Cardiovascular Health Study criteria to assess the frailty status of the study participants. The study participants were classified as non-frail, pre-frail and frail according to their physical activities. We compared plasma adiponectin levels among these three groups and applied a multivariate logistic regression analysis including plasma adiponectin levels to clarify the factors associated with frailty status in the cross-sectional design. Results: The mean age of the participants was 83.1±0.9years, and 51.8% were men. The frailty index was available to assess 353 participants, of whom 24.6% were classified as non-frail, 62.3% as prefrail and 13.0% as frail. The log-transformed plasma adiponectin levels increased stepwise in the following order: non-frail, pre-frail and frail. A multivariate logistic regression analysis showed that higher plasma adiponectin levels, a higher estimated glomerular filtration rate and lower hemoglobin levels were independent determinants for pre-frail/frail status compared with non-frail status. Conclusions: The present study showed that higher plasma adiponectin levels were associated with frailty status in older Japanese adults in the general population. Further longitudinal study is essential to clarify the role of plasma adiponectin in the progression of frailty.

Original languageEnglish
JournalGeriatrics and Gerontology International
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Adiponectin
Population
regression analysis
logistics
Logistic Models
Regression Analysis
longitudinal study
determinants
Glomerular Filtration Rate
Longitudinal Studies
health
Volunteers
Hemoglobins
Exercise
Group
Health

Keywords

  • Adiponectin
  • Cross-sectional study
  • Elderly
  • Frailty
  • Japanese

ASJC Scopus subject areas

  • Health(social science)
  • Gerontology
  • Geriatrics and Gerontology

Cite this

High plasma adiponectin levels are associated with frailty in a general old-old population : The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. / Nagasawa, Motonori; Takami, Yoichi; Akasaka, Hiroshi; Kabayama, Mai; Maeda, Satomi; Yokoyama, Serina; Fujimoto, Taku; Nozato, Yoichi; Imaizumi, Yuki; Takeda, Masao; Itoh, Norihisa; Takeya, Yasushi; Yamamoto, Koichi; Sugimoto, Ken; Nakagawa, Takeshi; Masui, Yukie; Arai, Yasumichi; Ishizaki, Tatsuro; Ikebe, Kazunori; Gondo, Yasuyuki; Kamide, Kei; Rakugi, Hiromi.

In: Geriatrics and Gerontology International, 01.01.2018.

Research output: Contribution to journalArticle

Nagasawa, M, Takami, Y, Akasaka, H, Kabayama, M, Maeda, S, Yokoyama, S, Fujimoto, T, Nozato, Y, Imaizumi, Y, Takeda, M, Itoh, N, Takeya, Y, Yamamoto, K, Sugimoto, K, Nakagawa, T, Masui, Y, Arai, Y, Ishizaki, T, Ikebe, K, Gondo, Y, Kamide, K & Rakugi, H 2018, 'High plasma adiponectin levels are associated with frailty in a general old-old population: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study', Geriatrics and Gerontology International. https://doi.org/10.1111/ggi.13258
Nagasawa, Motonori ; Takami, Yoichi ; Akasaka, Hiroshi ; Kabayama, Mai ; Maeda, Satomi ; Yokoyama, Serina ; Fujimoto, Taku ; Nozato, Yoichi ; Imaizumi, Yuki ; Takeda, Masao ; Itoh, Norihisa ; Takeya, Yasushi ; Yamamoto, Koichi ; Sugimoto, Ken ; Nakagawa, Takeshi ; Masui, Yukie ; Arai, Yasumichi ; Ishizaki, Tatsuro ; Ikebe, Kazunori ; Gondo, Yasuyuki ; Kamide, Kei ; Rakugi, Hiromi. / High plasma adiponectin levels are associated with frailty in a general old-old population : The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. In: Geriatrics and Gerontology International. 2018.
@article{67bfa8ee3d1542f390862d2575283eab,
title = "High plasma adiponectin levels are associated with frailty in a general old-old population: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study",
abstract = "Aim: The objective of the present study was to investigate the association between frailty and plasma adiponectin levels in a general population of Japanese older adults. Methods: The volunteer older adults, aged approximately 83years, were recruited randomly from a general population in the Japanese Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. We used the modified Cardiovascular Health Study criteria to assess the frailty status of the study participants. The study participants were classified as non-frail, pre-frail and frail according to their physical activities. We compared plasma adiponectin levels among these three groups and applied a multivariate logistic regression analysis including plasma adiponectin levels to clarify the factors associated with frailty status in the cross-sectional design. Results: The mean age of the participants was 83.1±0.9years, and 51.8{\%} were men. The frailty index was available to assess 353 participants, of whom 24.6{\%} were classified as non-frail, 62.3{\%} as prefrail and 13.0{\%} as frail. The log-transformed plasma adiponectin levels increased stepwise in the following order: non-frail, pre-frail and frail. A multivariate logistic regression analysis showed that higher plasma adiponectin levels, a higher estimated glomerular filtration rate and lower hemoglobin levels were independent determinants for pre-frail/frail status compared with non-frail status. Conclusions: The present study showed that higher plasma adiponectin levels were associated with frailty status in older Japanese adults in the general population. Further longitudinal study is essential to clarify the role of plasma adiponectin in the progression of frailty.",
keywords = "Adiponectin, Cross-sectional study, Elderly, Frailty, Japanese",
author = "Motonori Nagasawa and Yoichi Takami and Hiroshi Akasaka and Mai Kabayama and Satomi Maeda and Serina Yokoyama and Taku Fujimoto and Yoichi Nozato and Yuki Imaizumi and Masao Takeda and Norihisa Itoh and Yasushi Takeya and Koichi Yamamoto and Ken Sugimoto and Takeshi Nakagawa and Yukie Masui and Yasumichi Arai and Tatsuro Ishizaki and Kazunori Ikebe and Yasuyuki Gondo and Kei Kamide and Hiromi Rakugi",
year = "2018",
month = "1",
day = "1",
doi = "10.1111/ggi.13258",
language = "English",
journal = "Geriatrics and Gerontology International",
issn = "1447-0594",
publisher = "Japan Geriatrics Society",

}

TY - JOUR

T1 - High plasma adiponectin levels are associated with frailty in a general old-old population

T2 - The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study

AU - Nagasawa, Motonori

AU - Takami, Yoichi

AU - Akasaka, Hiroshi

AU - Kabayama, Mai

AU - Maeda, Satomi

AU - Yokoyama, Serina

AU - Fujimoto, Taku

AU - Nozato, Yoichi

AU - Imaizumi, Yuki

AU - Takeda, Masao

AU - Itoh, Norihisa

AU - Takeya, Yasushi

AU - Yamamoto, Koichi

AU - Sugimoto, Ken

AU - Nakagawa, Takeshi

AU - Masui, Yukie

AU - Arai, Yasumichi

AU - Ishizaki, Tatsuro

AU - Ikebe, Kazunori

AU - Gondo, Yasuyuki

AU - Kamide, Kei

AU - Rakugi, Hiromi

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Aim: The objective of the present study was to investigate the association between frailty and plasma adiponectin levels in a general population of Japanese older adults. Methods: The volunteer older adults, aged approximately 83years, were recruited randomly from a general population in the Japanese Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. We used the modified Cardiovascular Health Study criteria to assess the frailty status of the study participants. The study participants were classified as non-frail, pre-frail and frail according to their physical activities. We compared plasma adiponectin levels among these three groups and applied a multivariate logistic regression analysis including plasma adiponectin levels to clarify the factors associated with frailty status in the cross-sectional design. Results: The mean age of the participants was 83.1±0.9years, and 51.8% were men. The frailty index was available to assess 353 participants, of whom 24.6% were classified as non-frail, 62.3% as prefrail and 13.0% as frail. The log-transformed plasma adiponectin levels increased stepwise in the following order: non-frail, pre-frail and frail. A multivariate logistic regression analysis showed that higher plasma adiponectin levels, a higher estimated glomerular filtration rate and lower hemoglobin levels were independent determinants for pre-frail/frail status compared with non-frail status. Conclusions: The present study showed that higher plasma adiponectin levels were associated with frailty status in older Japanese adults in the general population. Further longitudinal study is essential to clarify the role of plasma adiponectin in the progression of frailty.

AB - Aim: The objective of the present study was to investigate the association between frailty and plasma adiponectin levels in a general population of Japanese older adults. Methods: The volunteer older adults, aged approximately 83years, were recruited randomly from a general population in the Japanese Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. We used the modified Cardiovascular Health Study criteria to assess the frailty status of the study participants. The study participants were classified as non-frail, pre-frail and frail according to their physical activities. We compared plasma adiponectin levels among these three groups and applied a multivariate logistic regression analysis including plasma adiponectin levels to clarify the factors associated with frailty status in the cross-sectional design. Results: The mean age of the participants was 83.1±0.9years, and 51.8% were men. The frailty index was available to assess 353 participants, of whom 24.6% were classified as non-frail, 62.3% as prefrail and 13.0% as frail. The log-transformed plasma adiponectin levels increased stepwise in the following order: non-frail, pre-frail and frail. A multivariate logistic regression analysis showed that higher plasma adiponectin levels, a higher estimated glomerular filtration rate and lower hemoglobin levels were independent determinants for pre-frail/frail status compared with non-frail status. Conclusions: The present study showed that higher plasma adiponectin levels were associated with frailty status in older Japanese adults in the general population. Further longitudinal study is essential to clarify the role of plasma adiponectin in the progression of frailty.

KW - Adiponectin

KW - Cross-sectional study

KW - Elderly

KW - Frailty

KW - Japanese

UR - http://www.scopus.com/inward/record.url?scp=85041369615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041369615&partnerID=8YFLogxK

U2 - 10.1111/ggi.13258

DO - 10.1111/ggi.13258

M3 - Article

C2 - 29392822

AN - SCOPUS:85041369615

JO - Geriatrics and Gerontology International

JF - Geriatrics and Gerontology International

SN - 1447-0594

ER -