High rate of inducible clindamycin resistance in Staphylococcus aureus isolates - A multicenter study in Tokyo, Japan

Kensuke Shoji, Masayoshi Shinjoh, Yuho Horikoshi, Julian Tang, Yasushi Watanabe, Kayoko Sugita, Tomoyuki Tame, Satoshi Iwata, Isao Miyairi, Akihiko Saitoh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The resistance of Staphylococcus aureus (. S.aureus) to antibiotics is an increasing problem. Clindamycin has been used as empiric therapy for the rising incidence of community-acquired methicillin-resistant S.aureus (MRSA). As such, the local rate of inducible resistance against clindamycin is an important consideration. This multicenter study was conducted to identify the incidence of inducible clindamycin resistance of S.aureus isolates in Tokyo, the most populous city in Japan. A total of 2408 adult and pediatric samples were collected from a university hospital and two pediatric hospitals between January 2011 and December 2011. Among the 2341 samples analyzed, the incidence of inducible clindamycin resistance in erythromycin-resistant and clindamycin-susceptible/intermediate isolates was found to be 91% (. n=585), a figure much higher compared to most reports from other countries. In conclusion, we found a very high rate of inducible clindamycin resistance in macrolide-resistant S.aureus isolates in our geographic area.

Original languageEnglish
Pages (from-to)81-83
Number of pages3
JournalJournal of Infection and Chemotherapy
Volume21
Issue number2
DOIs
Publication statusPublished - 2015 Feb 1

Keywords

  • Antistaphylococcal
  • Clindamycin
  • Inducible resistance
  • MRSA
  • MSSA

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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