High rate of inducible clindamycin resistance in Staphylococcus aureus isolates - A multicenter study in Tokyo, Japan

Kensuke Shoji; Masayoshi Shinjoh; Yuho Horikoshi; Julian Tang; Yasushi Watanabe; Kayoko Sugita; Tomoyuki Tame; Satoshi Iwata; Isao Miyairi; Akihiko Saitoh

doi:10.1016/j.jiac.2014.10.003

High rate of inducible clindamycin resistance in Staphylococcus aureus isolates - A multicenter study in Tokyo, Japan

Kensuke Shoji, Masayoshi Shinjoh, Yuho Horikoshi, Julian Tang, Yasushi Watanabe, Kayoko Sugita, Tomoyuki Tame, Satoshi Iwata, Isao Miyairi, Akihiko Saitoh

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The resistance of Staphylococcus aureus (. S.aureus) to antibiotics is an increasing problem. Clindamycin has been used as empiric therapy for the rising incidence of community-acquired methicillin-resistant S.aureus (MRSA). As such, the local rate of inducible resistance against clindamycin is an important consideration. This multicenter study was conducted to identify the incidence of inducible clindamycin resistance of S.aureus isolates in Tokyo, the most populous city in Japan. A total of 2408 adult and pediatric samples were collected from a university hospital and two pediatric hospitals between January 2011 and December 2011. Among the 2341 samples analyzed, the incidence of inducible clindamycin resistance in erythromycin-resistant and clindamycin-susceptible/intermediate isolates was found to be 91% (. n=585), a figure much higher compared to most reports from other countries. In conclusion, we found a very high rate of inducible clindamycin resistance in macrolide-resistant S.aureus isolates in our geographic area.

Original language	English
Pages (from-to)	81-83
Number of pages	3
Journal	Journal of Infection and Chemotherapy
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.jiac.2014.10.003
Publication status	Published - 2015 Feb 1

Keywords

Antistaphylococcal
Clindamycin
Inducible resistance
MRSA
MSSA

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiac.2014.10.003

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title = "High rate of inducible clindamycin resistance in Staphylococcus aureus isolates - A multicenter study in Tokyo, Japan",

abstract = "The resistance of Staphylococcus aureus (. S.aureus) to antibiotics is an increasing problem. Clindamycin has been used as empiric therapy for the rising incidence of community-acquired methicillin-resistant S.aureus (MRSA). As such, the local rate of inducible resistance against clindamycin is an important consideration. This multicenter study was conducted to identify the incidence of inducible clindamycin resistance of S.aureus isolates in Tokyo, the most populous city in Japan. A total of 2408 adult and pediatric samples were collected from a university hospital and two pediatric hospitals between January 2011 and December 2011. Among the 2341 samples analyzed, the incidence of inducible clindamycin resistance in erythromycin-resistant and clindamycin-susceptible/intermediate isolates was found to be 91% (. n=585), a figure much higher compared to most reports from other countries. In conclusion, we found a very high rate of inducible clindamycin resistance in macrolide-resistant S.aureus isolates in our geographic area.",

keywords = "Antistaphylococcal, Clindamycin, Inducible resistance, MRSA, MSSA",

author = "Kensuke Shoji and Masayoshi Shinjoh and Yuho Horikoshi and Julian Tang and Yasushi Watanabe and Kayoko Sugita and Tomoyuki Tame and Satoshi Iwata and Isao Miyairi and Akihiko Saitoh",

note = "Funding Information: This research was supported by funding from the National Center for Child Health and Development (24-11). Publisher Copyright: {\textcopyright} 2014 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.",

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doi = "10.1016/j.jiac.2014.10.003",

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T1 - High rate of inducible clindamycin resistance in Staphylococcus aureus isolates - A multicenter study in Tokyo, Japan

AU - Shoji, Kensuke

AU - Shinjoh, Masayoshi

AU - Horikoshi, Yuho

AU - Tang, Julian

AU - Watanabe, Yasushi

AU - Sugita, Kayoko

AU - Tame, Tomoyuki

AU - Iwata, Satoshi

AU - Miyairi, Isao

AU - Saitoh, Akihiko

N1 - Funding Information: This research was supported by funding from the National Center for Child Health and Development (24-11). Publisher Copyright: © 2014 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - The resistance of Staphylococcus aureus (. S.aureus) to antibiotics is an increasing problem. Clindamycin has been used as empiric therapy for the rising incidence of community-acquired methicillin-resistant S.aureus (MRSA). As such, the local rate of inducible resistance against clindamycin is an important consideration. This multicenter study was conducted to identify the incidence of inducible clindamycin resistance of S.aureus isolates in Tokyo, the most populous city in Japan. A total of 2408 adult and pediatric samples were collected from a university hospital and two pediatric hospitals between January 2011 and December 2011. Among the 2341 samples analyzed, the incidence of inducible clindamycin resistance in erythromycin-resistant and clindamycin-susceptible/intermediate isolates was found to be 91% (. n=585), a figure much higher compared to most reports from other countries. In conclusion, we found a very high rate of inducible clindamycin resistance in macrolide-resistant S.aureus isolates in our geographic area.

AB - The resistance of Staphylococcus aureus (. S.aureus) to antibiotics is an increasing problem. Clindamycin has been used as empiric therapy for the rising incidence of community-acquired methicillin-resistant S.aureus (MRSA). As such, the local rate of inducible resistance against clindamycin is an important consideration. This multicenter study was conducted to identify the incidence of inducible clindamycin resistance of S.aureus isolates in Tokyo, the most populous city in Japan. A total of 2408 adult and pediatric samples were collected from a university hospital and two pediatric hospitals between January 2011 and December 2011. Among the 2341 samples analyzed, the incidence of inducible clindamycin resistance in erythromycin-resistant and clindamycin-susceptible/intermediate isolates was found to be 91% (. n=585), a figure much higher compared to most reports from other countries. In conclusion, we found a very high rate of inducible clindamycin resistance in macrolide-resistant S.aureus isolates in our geographic area.

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KW - Clindamycin

KW - Inducible resistance

KW - MRSA

KW - MSSA

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High rate of inducible clindamycin resistance in Staphylococcus aureus isolates - A multicenter study in Tokyo, Japan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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