High-Resolution Vertical Observation of Intracellular Structure Using Magnetically Responsive Microplates

Tetsuhiko Teshima, Hiroaki Onoe, Soichiro Tottori, Hiroka Aonuma, Takeomi Mizutani, Koki Kamiya, Hirotaka Ishihara, Hirotaka Kanuka, Shoji Takeuchi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A vertical confocal observation system capable of high-resolution observation of intracellular structure is demonstrated. The system consists of magnet-active microplates to rotate, incline, and translate single adherent cells in the applied magnetic field. Appended to conventional confocal microscopes, this system enables high-resolution cross-sectional imaging with single-molecule sensitivity in single scanning.

Original languageEnglish
Pages (from-to)3366-3373
Number of pages8
JournalSmall
Volume12
Issue number25
DOIs
Publication statusPublished - 2016 Jul 1
Externally publishedYes

Keywords

  • confocal microscopy
  • cytoskeletons
  • magnetic materials
  • parylene
  • single cell analysis

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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