High serum level of P-selectin in patients responded to interferon-α treatment for chronic hepatitis C

Hidetsugu Saito, Hirotoshi Ebinuma, Kanji Tsuchimoto, Naoki Kumagai, Yasutaka Inagaki, Yoshio Mizuno, Jiro Nishida, Masahiro Yoshioka, Nobuyuki Ohkubo, Hirokazu Komatsu, Ken Mizukami, Hiromasa Ishii

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Circulating soluble P-selectin levels in sera of patients with chronic hepatitis C treated with natural interferon-α were investigated. Serum soluble P-selectin levels gradually increased after venesection when the sera were incubated at room temperature without serum separation, but the levels did not exceed more than 300 ng ml-1 during 3 h. Serum soluble P-selectin levels in patients who completely responded to interferon therapy were significantly higher than those in healthy subjects and other patients. Those levels in complete responders (CR) increased more than the base line levels 2 weeks after the initiation of the therapy and decreased to the base line levels 6 months after the end of the therapy, but the levels were still significantly higher than those in healthy subjects and non-responders (NR). The present preliminary study suggests that serum soluble P-selectin level is another useful marker for predicting response to natural interferon-α treatment in patients with chronic hepatitis C in addition to the established viral factors identified previously.

Original languageEnglish
Pages (from-to)225-236
Number of pages12
JournalHepatology Research
Volume10
Issue number3
Publication statusPublished - 1998 Mar

Fingerprint

P-Selectin
Chronic Hepatitis C
Interferons
Serum
Healthy Volunteers
Therapeutics
Phlebotomy
Temperature

Keywords

  • Chronic hepatitis C
  • Interferon treatment
  • Prediction of response
  • Soluble P-selectin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Saito, H., Ebinuma, H., Tsuchimoto, K., Kumagai, N., Inagaki, Y., Mizuno, Y., ... Ishii, H. (1998). High serum level of P-selectin in patients responded to interferon-α treatment for chronic hepatitis C. Hepatology Research, 10(3), 225-236.

High serum level of P-selectin in patients responded to interferon-α treatment for chronic hepatitis C. / Saito, Hidetsugu; Ebinuma, Hirotoshi; Tsuchimoto, Kanji; Kumagai, Naoki; Inagaki, Yasutaka; Mizuno, Yoshio; Nishida, Jiro; Yoshioka, Masahiro; Ohkubo, Nobuyuki; Komatsu, Hirokazu; Mizukami, Ken; Ishii, Hiromasa.

In: Hepatology Research, Vol. 10, No. 3, 03.1998, p. 225-236.

Research output: Contribution to journalArticle

Saito, H, Ebinuma, H, Tsuchimoto, K, Kumagai, N, Inagaki, Y, Mizuno, Y, Nishida, J, Yoshioka, M, Ohkubo, N, Komatsu, H, Mizukami, K & Ishii, H 1998, 'High serum level of P-selectin in patients responded to interferon-α treatment for chronic hepatitis C', Hepatology Research, vol. 10, no. 3, pp. 225-236.
Saito H, Ebinuma H, Tsuchimoto K, Kumagai N, Inagaki Y, Mizuno Y et al. High serum level of P-selectin in patients responded to interferon-α treatment for chronic hepatitis C. Hepatology Research. 1998 Mar;10(3):225-236.
Saito, Hidetsugu ; Ebinuma, Hirotoshi ; Tsuchimoto, Kanji ; Kumagai, Naoki ; Inagaki, Yasutaka ; Mizuno, Yoshio ; Nishida, Jiro ; Yoshioka, Masahiro ; Ohkubo, Nobuyuki ; Komatsu, Hirokazu ; Mizukami, Ken ; Ishii, Hiromasa. / High serum level of P-selectin in patients responded to interferon-α treatment for chronic hepatitis C. In: Hepatology Research. 1998 ; Vol. 10, No. 3. pp. 225-236.
@article{a2163a123438495a99c2aeb82fb93a1e,
title = "High serum level of P-selectin in patients responded to interferon-α treatment for chronic hepatitis C",
abstract = "Circulating soluble P-selectin levels in sera of patients with chronic hepatitis C treated with natural interferon-α were investigated. Serum soluble P-selectin levels gradually increased after venesection when the sera were incubated at room temperature without serum separation, but the levels did not exceed more than 300 ng ml-1 during 3 h. Serum soluble P-selectin levels in patients who completely responded to interferon therapy were significantly higher than those in healthy subjects and other patients. Those levels in complete responders (CR) increased more than the base line levels 2 weeks after the initiation of the therapy and decreased to the base line levels 6 months after the end of the therapy, but the levels were still significantly higher than those in healthy subjects and non-responders (NR). The present preliminary study suggests that serum soluble P-selectin level is another useful marker for predicting response to natural interferon-α treatment in patients with chronic hepatitis C in addition to the established viral factors identified previously.",
keywords = "Chronic hepatitis C, Interferon treatment, Prediction of response, Soluble P-selectin",
author = "Hidetsugu Saito and Hirotoshi Ebinuma and Kanji Tsuchimoto and Naoki Kumagai and Yasutaka Inagaki and Yoshio Mizuno and Jiro Nishida and Masahiro Yoshioka and Nobuyuki Ohkubo and Hirokazu Komatsu and Ken Mizukami and Hiromasa Ishii",
year = "1998",
month = "3",
language = "English",
volume = "10",
pages = "225--236",
journal = "Hepatology Research",
issn = "1386-6346",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",

}

TY - JOUR

T1 - High serum level of P-selectin in patients responded to interferon-α treatment for chronic hepatitis C

AU - Saito, Hidetsugu

AU - Ebinuma, Hirotoshi

AU - Tsuchimoto, Kanji

AU - Kumagai, Naoki

AU - Inagaki, Yasutaka

AU - Mizuno, Yoshio

AU - Nishida, Jiro

AU - Yoshioka, Masahiro

AU - Ohkubo, Nobuyuki

AU - Komatsu, Hirokazu

AU - Mizukami, Ken

AU - Ishii, Hiromasa

PY - 1998/3

Y1 - 1998/3

N2 - Circulating soluble P-selectin levels in sera of patients with chronic hepatitis C treated with natural interferon-α were investigated. Serum soluble P-selectin levels gradually increased after venesection when the sera were incubated at room temperature without serum separation, but the levels did not exceed more than 300 ng ml-1 during 3 h. Serum soluble P-selectin levels in patients who completely responded to interferon therapy were significantly higher than those in healthy subjects and other patients. Those levels in complete responders (CR) increased more than the base line levels 2 weeks after the initiation of the therapy and decreased to the base line levels 6 months after the end of the therapy, but the levels were still significantly higher than those in healthy subjects and non-responders (NR). The present preliminary study suggests that serum soluble P-selectin level is another useful marker for predicting response to natural interferon-α treatment in patients with chronic hepatitis C in addition to the established viral factors identified previously.

AB - Circulating soluble P-selectin levels in sera of patients with chronic hepatitis C treated with natural interferon-α were investigated. Serum soluble P-selectin levels gradually increased after venesection when the sera were incubated at room temperature without serum separation, but the levels did not exceed more than 300 ng ml-1 during 3 h. Serum soluble P-selectin levels in patients who completely responded to interferon therapy were significantly higher than those in healthy subjects and other patients. Those levels in complete responders (CR) increased more than the base line levels 2 weeks after the initiation of the therapy and decreased to the base line levels 6 months after the end of the therapy, but the levels were still significantly higher than those in healthy subjects and non-responders (NR). The present preliminary study suggests that serum soluble P-selectin level is another useful marker for predicting response to natural interferon-α treatment in patients with chronic hepatitis C in addition to the established viral factors identified previously.

KW - Chronic hepatitis C

KW - Interferon treatment

KW - Prediction of response

KW - Soluble P-selectin

UR - http://www.scopus.com/inward/record.url?scp=0032033669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032033669&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032033669

VL - 10

SP - 225

EP - 236

JO - Hepatology Research

JF - Hepatology Research

SN - 1386-6346

IS - 3

ER -