High serum total cholesterol is associated with suicide mortality in Japanese women

T. Svensson, M. Inoue, N. Sawada, H. Charvat, Masaru Mimura, S. Tsugane

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times. Method: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women. Results: There were 185 suicides (men: 107; women: 78) during follow-up. Compared to women with normal TC, women with high TC had a significantly increased risk of suicide (HR = 1.90, 95% CI, 1.13-3.19). Incremental increases (0.26 mmol/l [10 mg/dl]) of low-density lipoprotein (HR = 1.11, 95% CI, 1.02-1.21) and non-high-density lipoprotein cholesterol (HR = 1.09, 95% CI, 1.01-1.18) were also associated with increased risk of suicide in women. There was no association between TC levels, or lipid fractions, and suicide in men. Conclusion: High TC levels may be associated with an increased risk of suicide in women.

Original languageEnglish
JournalActa Psychiatrica Scandinavica
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Suicide
Cholesterol
Mortality
Serum
Confidence Intervals
Hypercholesterolemia
LDL Lipoproteins
Proportional Hazards Models
Japan
Public Health
Prospective Studies
Guidelines
Lipids
Population

Keywords

  • Cholesterol
  • Cohort
  • Epidemiology
  • Suicide
  • Women

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

High serum total cholesterol is associated with suicide mortality in Japanese women. / Svensson, T.; Inoue, M.; Sawada, N.; Charvat, H.; Mimura, Masaru; Tsugane, S.

In: Acta Psychiatrica Scandinavica, 2017.

Research output: Contribution to journalArticle

@article{7a59de6917c9445ab9d2a9a1d0df7776,
title = "High serum total cholesterol is associated with suicide mortality in Japanese women",
abstract = "Objective: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times. Method: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women. Results: There were 185 suicides (men: 107; women: 78) during follow-up. Compared to women with normal TC, women with high TC had a significantly increased risk of suicide (HR = 1.90, 95{\%} CI, 1.13-3.19). Incremental increases (0.26 mmol/l [10 mg/dl]) of low-density lipoprotein (HR = 1.11, 95{\%} CI, 1.02-1.21) and non-high-density lipoprotein cholesterol (HR = 1.09, 95{\%} CI, 1.01-1.18) were also associated with increased risk of suicide in women. There was no association between TC levels, or lipid fractions, and suicide in men. Conclusion: High TC levels may be associated with an increased risk of suicide in women.",
keywords = "Cholesterol, Cohort, Epidemiology, Suicide, Women",
author = "T. Svensson and M. Inoue and N. Sawada and H. Charvat and Masaru Mimura and S. Tsugane",
year = "2017",
doi = "10.1111/acps.12758",
language = "English",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - High serum total cholesterol is associated with suicide mortality in Japanese women

AU - Svensson, T.

AU - Inoue, M.

AU - Sawada, N.

AU - Charvat, H.

AU - Mimura, Masaru

AU - Tsugane, S.

PY - 2017

Y1 - 2017

N2 - Objective: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times. Method: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women. Results: There were 185 suicides (men: 107; women: 78) during follow-up. Compared to women with normal TC, women with high TC had a significantly increased risk of suicide (HR = 1.90, 95% CI, 1.13-3.19). Incremental increases (0.26 mmol/l [10 mg/dl]) of low-density lipoprotein (HR = 1.11, 95% CI, 1.02-1.21) and non-high-density lipoprotein cholesterol (HR = 1.09, 95% CI, 1.01-1.18) were also associated with increased risk of suicide in women. There was no association between TC levels, or lipid fractions, and suicide in men. Conclusion: High TC levels may be associated with an increased risk of suicide in women.

AB - Objective: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times. Method: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women. Results: There were 185 suicides (men: 107; women: 78) during follow-up. Compared to women with normal TC, women with high TC had a significantly increased risk of suicide (HR = 1.90, 95% CI, 1.13-3.19). Incremental increases (0.26 mmol/l [10 mg/dl]) of low-density lipoprotein (HR = 1.11, 95% CI, 1.02-1.21) and non-high-density lipoprotein cholesterol (HR = 1.09, 95% CI, 1.01-1.18) were also associated with increased risk of suicide in women. There was no association between TC levels, or lipid fractions, and suicide in men. Conclusion: High TC levels may be associated with an increased risk of suicide in women.

KW - Cholesterol

KW - Cohort

KW - Epidemiology

KW - Suicide

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=85019752758&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019752758&partnerID=8YFLogxK

U2 - 10.1111/acps.12758

DO - 10.1111/acps.12758

M3 - Article

C2 - 28547796

AN - SCOPUS:85019752758

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

ER -