High-signal-intensity MR image in the hepatobiliary phase predicts long-term survival in patients with hepatocellular carcinoma

Shun Ichi Ariizumi; Daisuke Ban; Yuta Abe; Takafumi Kumamoto; Satoshi Koizumi; Minoru Tanabe; Masahiro Shinoda; Itaru Endo; Takehito Otsubo; Masakazu Yamamoto

doi:10.21873/anticanres.13583

High-signal-intensity MR image in the hepatobiliary phase predicts long-term survival in patients with hepatocellular carcinoma

Shun Ichi Ariizumi, Daisuke Ban, Yuta Abe, Takafumi Kumamoto, Satoshi Koizumi, Minoru Tanabe, Masahiro Shinoda, Itaru Endo, Takehito Otsubo, Masakazu Yamamoto

Department of Surgery (General and Gastroenterological Surgery)

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Background/Aim: The aim of the study was to evaluate surgical outcomes of patients with high-signal intensity (SI) image hepatocellular carcinoma (HCC). Patients and Methods: Between 2008 and 2013, 257 HCC patients were retrospectively evaluated. A total of 21 patients were diagnosed as high-SI image HCC, 215 as low-SI image HCC, and 21 patients as mixed (high and low)-SI image HCC in the hepatobiliary (HB) phase of MRI. Five-year overall survival (OS) and recurrence-free survival (RFS) were compared among patient groups. Results: The 5-year OS and RFS rates were significantly higher in patients with high-SI image HCC (100% and 56%) than in patients with low-SI image HCC (71%; p=0.097 and 38%; p=0.0209) and in patients with mixed-SI image HCC (73%; p=0.0329 and 9%; p=0.0021). High-SI image was an independent prognostic factor for OS (relative risk 0.167, p=0.0178) and RFS (relative risk 0.471, p=0.0322) on multivariate analysis. Conclusion: Patients with high-SI image HCC showed favorable long-term survival after curative surgery.

Original language	English
Pages (from-to)	4219-4225
Number of pages	7
Journal	Anticancer research
Volume	39
Issue number	8
DOIs	https://doi.org/10.21873/anticanres.13583
Publication status	Published - 2019

Keywords

Gd-EOB-DTPA-enhanced MRI
Hepatocellular carcinoma
High-signal-intensity
Surgical outcome

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.13583

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@article{12cd7585a3bf480cb98d92c0ea8a2741,

title = "High-signal-intensity MR image in the hepatobiliary phase predicts long-term survival in patients with hepatocellular carcinoma",

abstract = "Background/Aim: The aim of the study was to evaluate surgical outcomes of patients with high-signal intensity (SI) image hepatocellular carcinoma (HCC). Patients and Methods: Between 2008 and 2013, 257 HCC patients were retrospectively evaluated. A total of 21 patients were diagnosed as high-SI image HCC, 215 as low-SI image HCC, and 21 patients as mixed (high and low)-SI image HCC in the hepatobiliary (HB) phase of MRI. Five-year overall survival (OS) and recurrence-free survival (RFS) were compared among patient groups. Results: The 5-year OS and RFS rates were significantly higher in patients with high-SI image HCC (100% and 56%) than in patients with low-SI image HCC (71%; p=0.097 and 38%; p=0.0209) and in patients with mixed-SI image HCC (73%; p=0.0329 and 9%; p=0.0021). High-SI image was an independent prognostic factor for OS (relative risk 0.167, p=0.0178) and RFS (relative risk 0.471, p=0.0322) on multivariate analysis. Conclusion: Patients with high-SI image HCC showed favorable long-term survival after curative surgery.",

keywords = "Gd-EOB-DTPA-enhanced MRI, Hepatocellular carcinoma, High-signal-intensity, Surgical outcome",

author = "Ariizumi, {Shun Ichi} and Daisuke Ban and Yuta Abe and Takafumi Kumamoto and Satoshi Koizumi and Minoru Tanabe and Masahiro Shinoda and Itaru Endo and Takehito Otsubo and Masakazu Yamamoto",

note = "Funding Information: The Authors are indebted to Associate Professor Raoul Breugelmans of the Department of Medical Education of Tokyo Medical University for his review of this manuscript. The authors are indebted to Dr. Ken Morita of the Department of Diagnostic Imaging and Nuclear Medicine of Tokyo Women{\textquoteright}s Medical University for his help to diagnose of high-or low-SI HCC. Publisher Copyright: {\textcopyright} 2019 International Institute of Anticancer Research. All rights reserved.",

year = "2019",

doi = "10.21873/anticanres.13583",

language = "English",

volume = "39",

pages = "4219--4225",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "8",

}

TY - JOUR

T1 - High-signal-intensity MR image in the hepatobiliary phase predicts long-term survival in patients with hepatocellular carcinoma

AU - Ariizumi, Shun Ichi

AU - Ban, Daisuke

AU - Abe, Yuta

AU - Kumamoto, Takafumi

AU - Koizumi, Satoshi

AU - Tanabe, Minoru

AU - Shinoda, Masahiro

AU - Endo, Itaru

AU - Otsubo, Takehito

AU - Yamamoto, Masakazu

N1 - Funding Information: The Authors are indebted to Associate Professor Raoul Breugelmans of the Department of Medical Education of Tokyo Medical University for his review of this manuscript. The authors are indebted to Dr. Ken Morita of the Department of Diagnostic Imaging and Nuclear Medicine of Tokyo Women’s Medical University for his help to diagnose of high-or low-SI HCC. Publisher Copyright: © 2019 International Institute of Anticancer Research. All rights reserved.

PY - 2019

Y1 - 2019

N2 - Background/Aim: The aim of the study was to evaluate surgical outcomes of patients with high-signal intensity (SI) image hepatocellular carcinoma (HCC). Patients and Methods: Between 2008 and 2013, 257 HCC patients were retrospectively evaluated. A total of 21 patients were diagnosed as high-SI image HCC, 215 as low-SI image HCC, and 21 patients as mixed (high and low)-SI image HCC in the hepatobiliary (HB) phase of MRI. Five-year overall survival (OS) and recurrence-free survival (RFS) were compared among patient groups. Results: The 5-year OS and RFS rates were significantly higher in patients with high-SI image HCC (100% and 56%) than in patients with low-SI image HCC (71%; p=0.097 and 38%; p=0.0209) and in patients with mixed-SI image HCC (73%; p=0.0329 and 9%; p=0.0021). High-SI image was an independent prognostic factor for OS (relative risk 0.167, p=0.0178) and RFS (relative risk 0.471, p=0.0322) on multivariate analysis. Conclusion: Patients with high-SI image HCC showed favorable long-term survival after curative surgery.

AB - Background/Aim: The aim of the study was to evaluate surgical outcomes of patients with high-signal intensity (SI) image hepatocellular carcinoma (HCC). Patients and Methods: Between 2008 and 2013, 257 HCC patients were retrospectively evaluated. A total of 21 patients were diagnosed as high-SI image HCC, 215 as low-SI image HCC, and 21 patients as mixed (high and low)-SI image HCC in the hepatobiliary (HB) phase of MRI. Five-year overall survival (OS) and recurrence-free survival (RFS) were compared among patient groups. Results: The 5-year OS and RFS rates were significantly higher in patients with high-SI image HCC (100% and 56%) than in patients with low-SI image HCC (71%; p=0.097 and 38%; p=0.0209) and in patients with mixed-SI image HCC (73%; p=0.0329 and 9%; p=0.0021). High-SI image was an independent prognostic factor for OS (relative risk 0.167, p=0.0178) and RFS (relative risk 0.471, p=0.0322) on multivariate analysis. Conclusion: Patients with high-SI image HCC showed favorable long-term survival after curative surgery.

KW - Gd-EOB-DTPA-enhanced MRI

KW - Hepatocellular carcinoma

KW - High-signal-intensity

KW - Surgical outcome

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U2 - 10.21873/anticanres.13583

DO - 10.21873/anticanres.13583

M3 - Article

C2 - 31366509

AN - SCOPUS:85070663568

SN - 0250-7005

VL - 39

SP - 4219

EP - 4225

JO - Anticancer Research

JF - Anticancer Research

IS - 8

ER -

High-signal-intensity MR image in the hepatobiliary phase predicts long-term survival in patients with hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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