High-signal-intensity MR image in the hepatobiliary phase predicts long-term survival in patients with hepatocellular carcinoma

Shun Ichi Ariizumi, Daisuke Ban, Yuta Abe, Takafumi Kumamoto, Satoshi Koizumi, Minoru Tanabe, Masahiro Shinoda, Itaru Endo, Takehito Otsubo, Masakazu Yamamoto

Research output: Contribution to journalArticle

Abstract

Background/Aim: The aim of the study was to evaluate surgical outcomes of patients with high-signal intensity (SI) image hepatocellular carcinoma (HCC). Patients and Methods: Between 2008 and 2013, 257 HCC patients were retrospectively evaluated. A total of 21 patients were diagnosed as high-SI image HCC, 215 as low-SI image HCC, and 21 patients as mixed (high and low)-SI image HCC in the hepatobiliary (HB) phase of MRI. Five-year overall survival (OS) and recurrence-free survival (RFS) were compared among patient groups. Results: The 5-year OS and RFS rates were significantly higher in patients with high-SI image HCC (100% and 56%) than in patients with low-SI image HCC (71%; p=0.097 and 38%; p=0.0209) and in patients with mixed-SI image HCC (73%; p=0.0329 and 9%; p=0.0021). High-SI image was an independent prognostic factor for OS (relative risk 0.167, p=0.0178) and RFS (relative risk 0.471, p=0.0322) on multivariate analysis. Conclusion: Patients with high-SI image HCC showed favorable long-term survival after curative surgery.

Original languageEnglish
Pages (from-to)4219-4225
Number of pages7
JournalAnticancer research
Volume39
Issue number8
DOIs
Publication statusPublished - 2019 Jan 1

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Hepatocellular Carcinoma
Survival
Recurrence
Multivariate Analysis
Survival Rate

Keywords

  • Gd-EOB-DTPA-enhanced MRI
  • Hepatocellular carcinoma
  • High-signal-intensity
  • Surgical outcome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

High-signal-intensity MR image in the hepatobiliary phase predicts long-term survival in patients with hepatocellular carcinoma. / Ariizumi, Shun Ichi; Ban, Daisuke; Abe, Yuta; Kumamoto, Takafumi; Koizumi, Satoshi; Tanabe, Minoru; Shinoda, Masahiro; Endo, Itaru; Otsubo, Takehito; Yamamoto, Masakazu.

In: Anticancer research, Vol. 39, No. 8, 01.01.2019, p. 4219-4225.

Research output: Contribution to journalArticle

Ariizumi, SI, Ban, D, Abe, Y, Kumamoto, T, Koizumi, S, Tanabe, M, Shinoda, M, Endo, I, Otsubo, T & Yamamoto, M 2019, 'High-signal-intensity MR image in the hepatobiliary phase predicts long-term survival in patients with hepatocellular carcinoma', Anticancer research, vol. 39, no. 8, pp. 4219-4225. https://doi.org/10.21873/anticanres.13583
Ariizumi, Shun Ichi ; Ban, Daisuke ; Abe, Yuta ; Kumamoto, Takafumi ; Koizumi, Satoshi ; Tanabe, Minoru ; Shinoda, Masahiro ; Endo, Itaru ; Otsubo, Takehito ; Yamamoto, Masakazu. / High-signal-intensity MR image in the hepatobiliary phase predicts long-term survival in patients with hepatocellular carcinoma. In: Anticancer research. 2019 ; Vol. 39, No. 8. pp. 4219-4225.
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abstract = "Background/Aim: The aim of the study was to evaluate surgical outcomes of patients with high-signal intensity (SI) image hepatocellular carcinoma (HCC). Patients and Methods: Between 2008 and 2013, 257 HCC patients were retrospectively evaluated. A total of 21 patients were diagnosed as high-SI image HCC, 215 as low-SI image HCC, and 21 patients as mixed (high and low)-SI image HCC in the hepatobiliary (HB) phase of MRI. Five-year overall survival (OS) and recurrence-free survival (RFS) were compared among patient groups. Results: The 5-year OS and RFS rates were significantly higher in patients with high-SI image HCC (100{\%} and 56{\%}) than in patients with low-SI image HCC (71{\%}; p=0.097 and 38{\%}; p=0.0209) and in patients with mixed-SI image HCC (73{\%}; p=0.0329 and 9{\%}; p=0.0021). High-SI image was an independent prognostic factor for OS (relative risk 0.167, p=0.0178) and RFS (relative risk 0.471, p=0.0322) on multivariate analysis. Conclusion: Patients with high-SI image HCC showed favorable long-term survival after curative surgery.",
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AU - Koizumi, Satoshi

AU - Tanabe, Minoru

AU - Shinoda, Masahiro

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