Highly β-selective mannosylation of 4,6-0-benzylidene-mannopyranosyl- N-phenyltrifluoroacetimidate (α/β, 5:95, 93% yield) has been realized by utilizing a dual Lewis acid/cation trap catalyst, TMSB(C6F 5)4. The obtained Manβ1-4GlcNTroc unit can be readily converted to a variety of N-linked oligosaccharides.
- Lewis acid
- Manβ1-4GlcNAc synthesis
- Stereoselective mannosylation
ASJC Scopus subject areas
- Organic Chemistry