Highly aligned skeletal muscle fibers

Yuto Shimoyama, Hiroaki Onoe, Yukiko Tsuda, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We propose highly aligned skeletal muscle fibers (Fig.1). We found that the textiles of a fibrin hydrogel fiber are highly orientated to the the longitudinal direction of the fiber by using a micro fluidic channel of a micro glass capillary tube. We also confirmed that the seeded skeletal muscle cells, C2C12, migrated into the fiber and aligned to the fiber direction without any complex lithographic patterning. Furthermore, the skeletal muscle cells in the fiber were differentiated to multinucleus myotubes. As a demonstration, we engineered artificial finger models by integrating our bundle and stretched skeletal muscle fibers to biocompatible polymer fingers. We believe that this would be an essential step to fabricate a soft material finger driven by the contraction of highly aligned skeletal muscle cells.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages2020-2022
Number of pages3
Publication statusPublished - 2010 Dec 1
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume3

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/10/310/10/7

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Keywords

  • Alignment of cells
  • Orientation of cell scaffolds
  • Skeletal muscle cells
  • Tissue engineering

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Shimoyama, Y., Onoe, H., Tsuda, Y., & Takeuchi, S. (2010). Highly aligned skeletal muscle fibers. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 2020-2022). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 3).