Highly chemo-, diastereo-, and enantioselective reduction of 1,2-dialkyl-3-aryl-1,3-diketones for preparation of aldol-type compounds

Yuhki Ohtsuka, Kiichirou Koyasu, Daichi Miyazaki, Taketo Ikeno, Tohru Yamada

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Equation presented Highly chemo-, diastereo-, and enantioselective borohydride reduction of 2-substituted-1,3-diketones was achieved in the presence of the optically active β-ketoiminato cobalt complex catalysts to afford the optically active 2-substituted-3-hydroxyketones. The present catalytic and enantioselective reduction could provide an alternative potential for preparation of optically active anti-aldol-type compounds.

Original languageEnglish
Pages (from-to)3421-3424
Number of pages4
JournalOrganic Letters
Volume3
Issue number21
DOIs
Publication statusPublished - 2001 Oct 18

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Borohydrides
Cobalt
preparation
borohydrides
cobalt
catalysts
Catalysts
3-hydroxybutanal

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Highly chemo-, diastereo-, and enantioselective reduction of 1,2-dialkyl-3-aryl-1,3-diketones for preparation of aldol-type compounds. / Ohtsuka, Yuhki; Koyasu, Kiichirou; Miyazaki, Daichi; Ikeno, Taketo; Yamada, Tohru.

In: Organic Letters, Vol. 3, No. 21, 18.10.2001, p. 3421-3424.

Research output: Contribution to journalArticle

Ohtsuka, Yuhki ; Koyasu, Kiichirou ; Miyazaki, Daichi ; Ikeno, Taketo ; Yamada, Tohru. / Highly chemo-, diastereo-, and enantioselective reduction of 1,2-dialkyl-3-aryl-1,3-diketones for preparation of aldol-type compounds. In: Organic Letters. 2001 ; Vol. 3, No. 21. pp. 3421-3424.
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