Highly chemo-, diastereo-, and enantioselective reduction of 1,2-dialkyl-3-aryl-1,3-diketones for preparation of aldol-type compounds

Yuhki Ohtsuka, Kiichirou Koyasu, Daichi Miyazaki, Taketo Ikeno, Tohru Yamada

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Equation presented Highly chemo-, diastereo-, and enantioselective borohydride reduction of 2-substituted-1,3-diketones was achieved in the presence of the optically active β-ketoiminato cobalt complex catalysts to afford the optically active 2-substituted-3-hydroxyketones. The present catalytic and enantioselective reduction could provide an alternative potential for preparation of optically active anti-aldol-type compounds.

Original languageEnglish
Pages (from-to)3421-3424
Number of pages4
JournalOrganic Letters
Volume3
Issue number21
DOIs
Publication statusPublished - 2001 Oct 18

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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