Highly diastereo- and enantioselective direct aldol reactions in water

Yujiro Hayashi; Tatsunobu Sumiya; Junichi Takahashi; Hiroaki Gotoh; Tatsuya Urushima; Mitsuru Shoji

doi:10.1002/anie.200502488

Highly diastereo- and enantioselective direct aldol reactions in water

Yujiro Hayashi, Tatsunobu Sumiya, Junichi Takahashi, Hiroaki Gotoh, Tatsuya Urushima, Mitsuru Shoji

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

472 Citations (Scopus)

Abstract

(Chemical Equation Presented) Going green: The synthetically very important aldol reaction can proceed in water without a metal catalyst with excellent enantioselectivity. The key to the reaction is a small, synthetic organic catalyst based on trans-hydroxyproline with a siloxy group. Thus, this method is an environmentally friendly process for the synthesis of chiral molecules.

Original language	English
Pages (from-to)	958-961
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	6
DOIs	https://doi.org/10.1002/anie.200502488
Publication status	Published - 2006 Jan 30

Keywords

Aldol reaction
Asymmetric synthesis
Diastereoselectivity
Organocatalysis
Solvent effects

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200502488

Cite this

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AU - Sumiya, Tatsunobu

AU - Takahashi, Junichi

AU - Gotoh, Hiroaki

AU - Urushima, Tatsuya

AU - Shoji, Mitsuru

PY - 2006/1/30

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KW - Aldol reaction

KW - Asymmetric synthesis

KW - Diastereoselectivity

KW - Organocatalysis

KW - Solvent effects

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Highly diastereo- and enantioselective direct aldol reactions in water

Abstract

Keywords

ASJC Scopus subject areas

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