Abstract
A novel method for total conversion of racemic mandelic acid into its (R)-enantiomer was developed. The method consists of enantioselective oxidation of (S)-(+)-mandelic acid by Alcaligenes bronchisepticus KU 1201 and NADH-dependent asymmetric reduction of resulting benzoylformic acid to (R)-mandelic acid with cell-free extract of Streptococcus faecalis IFO 12964.
| Original language | English |
|---|---|
| Pages (from-to) | 1137-1142 |
| Number of pages | 6 |
| Journal | Biotechnology Letters |
| Volume | 14 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 1992 Dec 1 |
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Applied Microbiology and Biotechnology
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Tsuchiya, S., Miyamoto, K., & Ohta, H. (1992). Highly efficient conversion of (±)-mandelic acid to its (R)-(-)-enantiomer by combination of enzyme-mediated oxidation and reduction. Biotechnology Letters, 14(12), 1137-1142. https://doi.org/10.1007/BF01027017