Highly efficient conversion of (±)-mandelic acid to its (R)-(-)-enantiomer by combination of enzyme-mediated oxidation and reduction

Shigeo Tsuchiya, Kenji Miyamoto, Hiromichi Ohta

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A novel method for total conversion of racemic mandelic acid into its (R)-enantiomer was developed. The method consists of enantioselective oxidation of (S)-(+)-mandelic acid by Alcaligenes bronchisepticus KU 1201 and NADH-dependent asymmetric reduction of resulting benzoylformic acid to (R)-mandelic acid with cell-free extract of Streptococcus faecalis IFO 12964.

Original languageEnglish
Pages (from-to)1137-1142
Number of pages6
JournalBiotechnology Letters
Volume14
Issue number12
DOIs
Publication statusPublished - 1992 Dec 1

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Fingerprint Dive into the research topics of 'Highly efficient conversion of (±)-mandelic acid to its (R)-(-)-enantiomer by combination of enzyme-mediated oxidation and reduction'. Together they form a unique fingerprint.

  • Cite this