The highly enantioselective reduction of 2-phenacylpyridine catalyzed by optically active β-ketoiminato cobalt(II) complexes with pre-modified sodium borohydride was achieved affording in high enantiomeric excess 1-phenyl-2-(2-pyridyl)ethanol, a precursor of sedamine derivatives. The enantioselective sense in the present reduction is discussed and compared to the asymmetric reduction catalyzed by other complex catalysts. Copyright (C) 2000 Elsevier Science Ltd.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry