Highly enantioselective cyclopropanation in alcoholic and aqueous solvents catalyzed by optically active β-ketoiminato cobalt(II) complex

T. Ikeno; A. Nishizuka; M. Sato; T. Yamada

doi:10.1055/s-2001-11416

Highly enantioselective cyclopropanation in alcoholic and aqueous solvents catalyzed by optically active β-ketoiminato cobalt(II) complex

T. Ikeno, A. Nishizuka, M. Sato, T. Yamada

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The highly enantioselective cyclopropanation of styrenes and diazoacetates proceeded in alcohol or aqueous alcohol in the presence of the β-ketoiminato cobalt(II) complex. Water and alcohols accelerated the reaction and improved the diastereo- and enantioselectivities. In these media, the α,α-disubstituted styrenes were smoothly cyclopropanated with high enantiomeric excess.

Original language	English
Pages (from-to)	406-408
Number of pages	3
Journal	Synlett
Issue number	3
DOIs	https://doi.org/10.1055/s-2001-11416
Publication status	Published - 2001

Keywords

Alcohols
Asymmetric synthesis
Cobalt
Cyclopropanation
Water

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-2001-11416

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abstract = "The highly enantioselective cyclopropanation of styrenes and diazoacetates proceeded in alcohol or aqueous alcohol in the presence of the β-ketoiminato cobalt(II) complex. Water and alcohols accelerated the reaction and improved the diastereo- and enantioselectivities. In these media, the α,α-disubstituted styrenes were smoothly cyclopropanated with high enantiomeric excess.",

keywords = "Alcohols, Asymmetric synthesis, Cobalt, Cyclopropanation, Water",

author = "T. Ikeno and A. Nishizuka and M. Sato and T. Yamada",

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AU - Ikeno, T.

AU - Nishizuka, A.

AU - Sato, M.

AU - Yamada, T.

PY - 2001

Y1 - 2001

N2 - The highly enantioselective cyclopropanation of styrenes and diazoacetates proceeded in alcohol or aqueous alcohol in the presence of the β-ketoiminato cobalt(II) complex. Water and alcohols accelerated the reaction and improved the diastereo- and enantioselectivities. In these media, the α,α-disubstituted styrenes were smoothly cyclopropanated with high enantiomeric excess.

AB - The highly enantioselective cyclopropanation of styrenes and diazoacetates proceeded in alcohol or aqueous alcohol in the presence of the β-ketoiminato cobalt(II) complex. Water and alcohols accelerated the reaction and improved the diastereo- and enantioselectivities. In these media, the α,α-disubstituted styrenes were smoothly cyclopropanated with high enantiomeric excess.

KW - Alcohols

KW - Asymmetric synthesis

KW - Cobalt

KW - Cyclopropanation

KW - Water

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