The highly enantioselective cyclopropanation of styrenes and diazoacetates proceeded in alcohol or aqueous alcohol in the presence of the β-ketoiminato cobalt(II) complex. Water and alcohols accelerated the reaction and improved the diastereo- and enantioselectivities. In these media, the α,α-disubstituted styrenes were smoothly cyclopropanated with high enantiomeric excess.
|Number of pages||3|
|Publication status||Published - 2001 Mar 26|
- Asymmetric synthesis
ASJC Scopus subject areas
- Organic Chemistry