Highly enantioselective cyclopropanation in alcoholic and aqueous solvents catalyzed by optically active β-ketoiminato cobalt(II) complex

T. Ikeno, A. Nishizuka, M. Sato, T. Yamada

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Abstract

The highly enantioselective cyclopropanation of styrenes and diazoacetates proceeded in alcohol or aqueous alcohol in the presence of the β-ketoiminato cobalt(II) complex. Water and alcohols accelerated the reaction and improved the diastereo- and enantioselectivities. In these media, the α,α-disubstituted styrenes were smoothly cyclopropanated with high enantiomeric excess.

Original languageEnglish
Pages (from-to)406-408
Number of pages3
JournalSynlett
Issue number3
Publication statusPublished - 2001 Mar 26

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Keywords

  • Alcohols
  • Asymmetric synthesis
  • Cobalt
  • Cyclopropanation
  • Water

ASJC Scopus subject areas

  • Organic Chemistry

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