Highly selective hydroxylation of benzene to phenol by wild-type cytochrome P450BM3 assisted by decoy molecules

Osami Shoji, Tatsuya Kunimatsu, Norifumi Kawakami, Yoshihito Watanabe

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Playing tricks on enzymes: Direct hydroxylation of benzene to phenol was catalyzed by wild-type P450BM3 in the presence of perfluorinated carboxylic acids as decoy molecules. The catalytic turnover rate reached 120 min -1 per P450. The selectivity towards phenol production was very high and no overoxidation products were detected.

Original languageEnglish
Pages (from-to)6606-6610
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number26
DOIs
Publication statusPublished - 2013 Jun 24
Externally publishedYes

Keywords

  • carboxylic acid
  • cytochromes
  • decoy molecule
  • hydroxylation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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