Abstract
Playing tricks on enzymes: Direct hydroxylation of benzene to phenol was catalyzed by wild-type P450BM3 in the presence of perfluorinated carboxylic acids as decoy molecules. The catalytic turnover rate reached 120 min -1 per P450. The selectivity towards phenol production was very high and no overoxidation products were detected.
Original language | English |
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Pages (from-to) | 6606-6610 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 52 |
Issue number | 26 |
DOIs | |
Publication status | Published - 2013 Jun 24 |
Externally published | Yes |
Keywords
- carboxylic acid
- cytochromes
- decoy molecule
- hydroxylation
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)