Abstract
Playing tricks on enzymes: Direct hydroxylation of benzene to phenol was catalyzed by wild-type P450BM3 in the presence of perfluorinated carboxylic acids as decoy molecules. The catalytic turnover rate reached 120 min -1 per P450. The selectivity towards phenol production was very high and no overoxidation products were detected.
| Original language | English |
|---|---|
| Pages (from-to) | 6606-6610 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 26 |
| DOIs | |
| Publication status | Published - 2013 Jun 24 |
| Externally published | Yes |
Keywords
- carboxylic acid
- cytochromes
- decoy molecule
- hydroxylation
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Shoji, O., Kunimatsu, T., Kawakami, N., & Watanabe, Y. (2013). Highly selective hydroxylation of benzene to phenol by wild-type cytochrome P450BM3 assisted by decoy molecules. Angewandte Chemie - International Edition, 52(26), 6606-6610. https://doi.org/10.1002/anie.201300282