Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs

Eita Sasaki, Hirotatsu Kojima, Hiroaki Nishimatsu, Yasuteru Urano, Kazuya Kikuchi, Yasunobu Hirata, Tetsuo Nagano

Research output: Contribution to journalArticlepeer-review

369 Citations (Scopus)

Abstract

Novel near-infrared (NIR) fluorescent probes for nitric oxide (NO) have been designed, synthesized, and evaluated. Their NIR fluorescence was increased in an NO concentration-dependent manner under physiological conditions, and their reaction efficiency with NO was at least 53 times higher than that of a widely used NO probe, DAF-2. They were confirmed to function in isolated intact rat kidneys. Because NIR light can penetrate deeply into tissues, these probes may have potential for in vivo NO imaging.

Original languageEnglish
Pages (from-to)3684-3685
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number11
DOIs
Publication statusPublished - 2005 Mar 23
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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