Highly stretchable cell-laden hydrogel microfiber

Fumisato Ozawa, Hiroaki Onoe, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

This conference proceeding describes a highly stretchable cell-laden hydrogel microfiber using doublenetwork hydrogels. Previously, a useful method involving the implantation of rat primary islet cell fibers for the treatment of diabetic mice was reported [1]. However, normal microfiber constructed from alginate hydrogel shell is too weak to be handled by hand manipulation. We here develop an approach to improve the shell material and developed highly stretchable cell-laden hydrogel microfibers. Using the doublenetwork hydrogel consisted of alginate-calcium and polyacrylamide as the microfiber's shell, the microfibers showed high stretchability with about 6 times higher than that of the existing hydrogel microfibers. The highly stretchable cell fibers would be useful for the application in robust suture-type tissue grafts and the double-network hydrogel shell serve a function of immunity isolating membrane.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages1880-1881
Number of pages2
ISBN (Print)9780979806476
Publication statusPublished - 2014
Externally publishedYes
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 2014 Oct 262014 Oct 30

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period14/10/2614/10/30

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Keywords

  • 3D cell culture
  • Hydrogel
  • Microfiber

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Ozawa, F., Onoe, H., & Takeuchi, S. (2014). Highly stretchable cell-laden hydrogel microfiber. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 1880-1881). Chemical and Biological Microsystems Society.