Highly stretchable cell-laden hydrogel microfiber

Fumisato Ozawa, Hiroaki Onoe, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

This conference proceeding describes a highly stretchable cell-laden hydrogel microfiber using doublenetwork hydrogels. Previously, a useful method involving the implantation of rat primary islet cell fibers for the treatment of diabetic mice was reported [1]. However, normal microfiber constructed from alginate hydrogel shell is too weak to be handled by hand manipulation. We here develop an approach to improve the shell material and developed highly stretchable cell-laden hydrogel microfibers. Using the doublenetwork hydrogel consisted of alginate-calcium and polyacrylamide as the microfiber's shell, the microfibers showed high stretchability with about 6 times higher than that of the existing hydrogel microfibers. The highly stretchable cell fibers would be useful for the application in robust suture-type tissue grafts and the double-network hydrogel shell serve a function of immunity isolating membrane.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages1880-1881
Number of pages2
ISBN (Print)9780979806476
Publication statusPublished - 2014
Externally publishedYes
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 2014 Oct 262014 Oct 30

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period14/10/2614/10/30

Fingerprint

Hydrogels
Alginate
Fibers
Polyacrylates
Grafts
Rats
Calcium
Tissue
Membranes

Keywords

  • 3D cell culture
  • Hydrogel
  • Microfiber

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Ozawa, F., Onoe, H., & Takeuchi, S. (2014). Highly stretchable cell-laden hydrogel microfiber. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 1880-1881). Chemical and Biological Microsystems Society.

Highly stretchable cell-laden hydrogel microfiber. / Ozawa, Fumisato; Onoe, Hiroaki; Takeuchi, Shoji.

18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 1880-1881.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ozawa, F, Onoe, H & Takeuchi, S 2014, Highly stretchable cell-laden hydrogel microfiber. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, pp. 1880-1881, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, United States, 14/10/26.
Ozawa F, Onoe H, Takeuchi S. Highly stretchable cell-laden hydrogel microfiber. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society. 2014. p. 1880-1881
Ozawa, Fumisato ; Onoe, Hiroaki ; Takeuchi, Shoji. / Highly stretchable cell-laden hydrogel microfiber. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. pp. 1880-1881
@inproceedings{e6c03e5ee2084eb489c9889e0d47e389,
title = "Highly stretchable cell-laden hydrogel microfiber",
abstract = "This conference proceeding describes a highly stretchable cell-laden hydrogel microfiber using doublenetwork hydrogels. Previously, a useful method involving the implantation of rat primary islet cell fibers for the treatment of diabetic mice was reported [1]. However, normal microfiber constructed from alginate hydrogel shell is too weak to be handled by hand manipulation. We here develop an approach to improve the shell material and developed highly stretchable cell-laden hydrogel microfibers. Using the doublenetwork hydrogel consisted of alginate-calcium and polyacrylamide as the microfiber's shell, the microfibers showed high stretchability with about 6 times higher than that of the existing hydrogel microfibers. The highly stretchable cell fibers would be useful for the application in robust suture-type tissue grafts and the double-network hydrogel shell serve a function of immunity isolating membrane.",
keywords = "3D cell culture, Hydrogel, Microfiber",
author = "Fumisato Ozawa and Hiroaki Onoe and Shoji Takeuchi",
year = "2014",
language = "English",
isbn = "9780979806476",
pages = "1880--1881",
booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",
publisher = "Chemical and Biological Microsystems Society",

}

TY - GEN

T1 - Highly stretchable cell-laden hydrogel microfiber

AU - Ozawa, Fumisato

AU - Onoe, Hiroaki

AU - Takeuchi, Shoji

PY - 2014

Y1 - 2014

N2 - This conference proceeding describes a highly stretchable cell-laden hydrogel microfiber using doublenetwork hydrogels. Previously, a useful method involving the implantation of rat primary islet cell fibers for the treatment of diabetic mice was reported [1]. However, normal microfiber constructed from alginate hydrogel shell is too weak to be handled by hand manipulation. We here develop an approach to improve the shell material and developed highly stretchable cell-laden hydrogel microfibers. Using the doublenetwork hydrogel consisted of alginate-calcium and polyacrylamide as the microfiber's shell, the microfibers showed high stretchability with about 6 times higher than that of the existing hydrogel microfibers. The highly stretchable cell fibers would be useful for the application in robust suture-type tissue grafts and the double-network hydrogel shell serve a function of immunity isolating membrane.

AB - This conference proceeding describes a highly stretchable cell-laden hydrogel microfiber using doublenetwork hydrogels. Previously, a useful method involving the implantation of rat primary islet cell fibers for the treatment of diabetic mice was reported [1]. However, normal microfiber constructed from alginate hydrogel shell is too weak to be handled by hand manipulation. We here develop an approach to improve the shell material and developed highly stretchable cell-laden hydrogel microfibers. Using the doublenetwork hydrogel consisted of alginate-calcium and polyacrylamide as the microfiber's shell, the microfibers showed high stretchability with about 6 times higher than that of the existing hydrogel microfibers. The highly stretchable cell fibers would be useful for the application in robust suture-type tissue grafts and the double-network hydrogel shell serve a function of immunity isolating membrane.

KW - 3D cell culture

KW - Hydrogel

KW - Microfiber

UR - http://www.scopus.com/inward/record.url?scp=84941662978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941662978&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84941662978

SN - 9780979806476

SP - 1880

EP - 1881

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

ER -