Abstract
This conference proceeding describes a highly stretchable cell-laden hydrogel microfiber using doublenetwork hydrogels. Previously, a useful method involving the implantation of rat primary islet cell fibers for the treatment of diabetic mice was reported [1]. However, normal microfiber constructed from alginate hydrogel shell is too weak to be handled by hand manipulation. We here develop an approach to improve the shell material and developed highly stretchable cell-laden hydrogel microfibers. Using the doublenetwork hydrogel consisted of alginate-calcium and polyacrylamide as the microfiber's shell, the microfibers showed high stretchability with about 6 times higher than that of the existing hydrogel microfibers. The highly stretchable cell fibers would be useful for the application in robust suture-type tissue grafts and the double-network hydrogel shell serve a function of immunity isolating membrane.
| Original language | English |
|---|---|
| Title of host publication | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1880-1881 |
| Number of pages | 2 |
| ISBN (Print) | 9780979806476 |
| Publication status | Published - 2014 |
| Externally published | Yes |
| Event | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: 2014 Oct 26 → 2014 Oct 30 |
Other
| Other | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 |
|---|---|
| Country | United States |
| City | San Antonio |
| Period | 14/10/26 → 14/10/30 |
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Keywords
- 3D cell culture
- Hydrogel
- Microfiber
ASJC Scopus subject areas
- Control and Systems Engineering
Cite this
Highly stretchable cell-laden hydrogel microfiber. / Ozawa, Fumisato; Onoe, Hiroaki; Takeuchi, Shoji.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 1880-1881.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Highly stretchable cell-laden hydrogel microfiber
AU - Ozawa, Fumisato
AU - Onoe, Hiroaki
AU - Takeuchi, Shoji
PY - 2014
Y1 - 2014
N2 - This conference proceeding describes a highly stretchable cell-laden hydrogel microfiber using doublenetwork hydrogels. Previously, a useful method involving the implantation of rat primary islet cell fibers for the treatment of diabetic mice was reported [1]. However, normal microfiber constructed from alginate hydrogel shell is too weak to be handled by hand manipulation. We here develop an approach to improve the shell material and developed highly stretchable cell-laden hydrogel microfibers. Using the doublenetwork hydrogel consisted of alginate-calcium and polyacrylamide as the microfiber's shell, the microfibers showed high stretchability with about 6 times higher than that of the existing hydrogel microfibers. The highly stretchable cell fibers would be useful for the application in robust suture-type tissue grafts and the double-network hydrogel shell serve a function of immunity isolating membrane.
AB - This conference proceeding describes a highly stretchable cell-laden hydrogel microfiber using doublenetwork hydrogels. Previously, a useful method involving the implantation of rat primary islet cell fibers for the treatment of diabetic mice was reported [1]. However, normal microfiber constructed from alginate hydrogel shell is too weak to be handled by hand manipulation. We here develop an approach to improve the shell material and developed highly stretchable cell-laden hydrogel microfibers. Using the doublenetwork hydrogel consisted of alginate-calcium and polyacrylamide as the microfiber's shell, the microfibers showed high stretchability with about 6 times higher than that of the existing hydrogel microfibers. The highly stretchable cell fibers would be useful for the application in robust suture-type tissue grafts and the double-network hydrogel shell serve a function of immunity isolating membrane.
KW - 3D cell culture
KW - Hydrogel
KW - Microfiber
UR - http://www.scopus.com/inward/record.url?scp=84941662978&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941662978&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84941662978
SN - 9780979806476
SP - 1880
EP - 1881
BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PB - Chemical and Biological Microsystems Society
ER -