hiiragi, a gene essential for wing development in Drosophila melanogaster, affects the Notch cascade

Takehide Murata, Keiji Ogura, Ryutaro Murakami, Hideyuki Okano, Kazunari K. Yokoyama

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A recessive mutation, hiiragi(P1), on the second chromosome of Drosophila was obtained by P element insertion mutagenesis. Flies homozygous for hiiragi(P1) have notched wing margins. Genetic interactions between hiiragi and the genes that encode components of Notch signaling, such as Notch, Hairless, Serrate and deltex, strongly support the involvement of hiiragi in the signal transduction cascade of Notch. It has been reported that Serrate and Delta, other components of Notch signaling, share EGF-like repeats and a second conserved cysteine-rich motif, and that these components interact physically with the same region of Notch. In hiiragi(P1); Serrate(D)/+ double mutants, we observed synergistic enhancement of the notched phenotype of wing margins. In contrast, Delta(FX3) had no phenotypic effect on hiiragi(P1) in hiiragi(P1); Delta(FX3)/+ double mutants. Taken together, these results indicate that hiiragi is involved in the Notch signaling cascade induced by Serrate rather than by Delta.

Original languageEnglish
Pages (from-to)247-254
Number of pages8
JournalGenes and Genetic Systems
Volume71
Issue number4
DOIs
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Gene Components
Cascades (fluid mechanics)
Essential Genes
Drosophila melanogaster
Epidermal Growth Factor
Mutagenesis
Diptera
Drosophila
Cysteine
Signal Transduction
Genes
Chromosomes
Phenotype
mutants
Mutation
mutagenesis
transposons
cysteine
signal transduction
Signal transduction

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Genetics
  • Genetics(clinical)

Cite this

hiiragi, a gene essential for wing development in Drosophila melanogaster, affects the Notch cascade. / Murata, Takehide; Ogura, Keiji; Murakami, Ryutaro; Okano, Hideyuki; Yokoyama, Kazunari K.

In: Genes and Genetic Systems, Vol. 71, No. 4, 1996, p. 247-254.

Research output: Contribution to journalArticle

Murata, Takehide ; Ogura, Keiji ; Murakami, Ryutaro ; Okano, Hideyuki ; Yokoyama, Kazunari K. / hiiragi, a gene essential for wing development in Drosophila melanogaster, affects the Notch cascade. In: Genes and Genetic Systems. 1996 ; Vol. 71, No. 4. pp. 247-254.
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