Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: Synaptocrinology

H. Mukai, N. Takata, H. T. Ishii, N. Tanabe, Y. Hojo, A. Furukawa, T. Kimoto, S. Kawato

Research output: Contribution to journalArticlepeer-review

98 Citations (Scopus)

Abstract

Hippocampal pyramidal neurons and granule neurons of adult male rats are equipped with a complete machinery for the synthesis of pregnenolone, dehydroepiandrosterone, testosterone, dihydrotestosterone and 17β-estradiol. Both estrogens and androgens are synthesized in male hippocampus. These brain steroids are synthesized by cytochrome P450s (P450scc, P45017α and P450arom), hydroxysteroid dehydrogenases and reductases from endogenous cholesterol. The expression levels of enzymes are as low as 1/300-1/1000 of those in endocrine organs. Synthesis is dependent on the acute Ca2+ influx upon neuron-neuron communication via NMDA receptors. Estradiol is particularly important because estradiol rapidly modulates neuronal synaptic transmission such as long-term potentiation via synaptic estrogen receptors. Xenoestrogens may also act via estrogen-driven signaling pathways.

Original languageEnglish
Pages (from-to)757-764
Number of pages8
JournalNeuroscience
Volume138
Issue number3
DOIs
Publication statusPublished - 2006
Externally publishedYes

Keywords

  • Endocrine disrupter
  • Estradiol
  • Hippocampus
  • Neurosteroid
  • P450

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: Synaptocrinology'. Together they form a unique fingerprint.

Cite this