Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia - reperfusion

Toshifumi Yoshida, Ryuichi Iwakiri, Takahiro Noda, Kazuyo Okamoto, Masataka Kojima, Koji Fukuyama, Kazuma Fujimoto

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia - reperfusion in the rat intestine. The superior mesenteric artery was occluded for 60 min followed by reperfusion for 60 min. Rats were infused with H1-receptor antagonist (chlorpheniramine maleate) or H2-receptor antagonist (cimetidine). Additional rats were pretreated with aminoguanidine (100 mg/kg). Percent apoptosis in the intestinal mucosa increased after reperfusion, but neither H1 nor H2 antagonists had any effect on apoptosis. Aminoguanidine pretreatment inhibited activity of diamine oxidase and increased the plasma histamine concentration. Aminoguanidine attenuated the increase in mucosal apoptosis following reperfusion. Apoptosis induced by an ischemic insult to the intestinal mucosa was not related to an undesirable effect of histamine. Attenuation of increased intestinal apoptosis might be due to increased plasma histamine level and/or other pharmacological action of amioguanidine, including inhibition of inducible nitric oxide synthase.

Original languageEnglish
Pages (from-to)1138-1144
Number of pages7
JournalDigestive Diseases and Sciences
Volume45
Issue number6
DOIs
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Histamine Agents
Intestinal Mucosa
Reperfusion
Ischemia
Apoptosis
Histamine
Chlorpheniramine
Amine Oxidase (Copper-Containing)
Histamine H1 Receptors
Histamine H2 Receptors
Superior Mesenteric Artery
Cimetidine
Nitric Oxide Synthase Type II
Intestines
Pharmacology
pimagedine

Keywords

  • Aminoguanidine
  • Diamine oxidase
  • Fragmented DNA
  • H-receptor antagonist
  • H-receptor antagonist
  • Nitric oxide

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia - reperfusion. / Yoshida, Toshifumi; Iwakiri, Ryuichi; Noda, Takahiro; Okamoto, Kazuyo; Kojima, Masataka; Fukuyama, Koji; Fujimoto, Kazuma.

In: Digestive Diseases and Sciences, Vol. 45, No. 6, 2000, p. 1138-1144.

Research output: Contribution to journalArticle

Yoshida, Toshifumi ; Iwakiri, Ryuichi ; Noda, Takahiro ; Okamoto, Kazuyo ; Kojima, Masataka ; Fukuyama, Koji ; Fujimoto, Kazuma. / Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia - reperfusion. In: Digestive Diseases and Sciences. 2000 ; Vol. 45, No. 6. pp. 1138-1144.
@article{2ca21bde833e48b5b5841485b5863e54,
title = "Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia - reperfusion",
abstract = "This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia - reperfusion in the rat intestine. The superior mesenteric artery was occluded for 60 min followed by reperfusion for 60 min. Rats were infused with H1-receptor antagonist (chlorpheniramine maleate) or H2-receptor antagonist (cimetidine). Additional rats were pretreated with aminoguanidine (100 mg/kg). Percent apoptosis in the intestinal mucosa increased after reperfusion, but neither H1 nor H2 antagonists had any effect on apoptosis. Aminoguanidine pretreatment inhibited activity of diamine oxidase and increased the plasma histamine concentration. Aminoguanidine attenuated the increase in mucosal apoptosis following reperfusion. Apoptosis induced by an ischemic insult to the intestinal mucosa was not related to an undesirable effect of histamine. Attenuation of increased intestinal apoptosis might be due to increased plasma histamine level and/or other pharmacological action of amioguanidine, including inhibition of inducible nitric oxide synthase.",
keywords = "Aminoguanidine, Diamine oxidase, Fragmented DNA, H-receptor antagonist, H-receptor antagonist, Nitric oxide",
author = "Toshifumi Yoshida and Ryuichi Iwakiri and Takahiro Noda and Kazuyo Okamoto and Masataka Kojima and Koji Fukuyama and Kazuma Fujimoto",
year = "2000",
doi = "10.1023/A:1005545801714",
language = "English",
volume = "45",
pages = "1138--1144",
journal = "American Journal of Digestive Diseases",
issn = "0002-9211",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia - reperfusion

AU - Yoshida, Toshifumi

AU - Iwakiri, Ryuichi

AU - Noda, Takahiro

AU - Okamoto, Kazuyo

AU - Kojima, Masataka

AU - Fukuyama, Koji

AU - Fujimoto, Kazuma

PY - 2000

Y1 - 2000

N2 - This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia - reperfusion in the rat intestine. The superior mesenteric artery was occluded for 60 min followed by reperfusion for 60 min. Rats were infused with H1-receptor antagonist (chlorpheniramine maleate) or H2-receptor antagonist (cimetidine). Additional rats were pretreated with aminoguanidine (100 mg/kg). Percent apoptosis in the intestinal mucosa increased after reperfusion, but neither H1 nor H2 antagonists had any effect on apoptosis. Aminoguanidine pretreatment inhibited activity of diamine oxidase and increased the plasma histamine concentration. Aminoguanidine attenuated the increase in mucosal apoptosis following reperfusion. Apoptosis induced by an ischemic insult to the intestinal mucosa was not related to an undesirable effect of histamine. Attenuation of increased intestinal apoptosis might be due to increased plasma histamine level and/or other pharmacological action of amioguanidine, including inhibition of inducible nitric oxide synthase.

AB - This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia - reperfusion in the rat intestine. The superior mesenteric artery was occluded for 60 min followed by reperfusion for 60 min. Rats were infused with H1-receptor antagonist (chlorpheniramine maleate) or H2-receptor antagonist (cimetidine). Additional rats were pretreated with aminoguanidine (100 mg/kg). Percent apoptosis in the intestinal mucosa increased after reperfusion, but neither H1 nor H2 antagonists had any effect on apoptosis. Aminoguanidine pretreatment inhibited activity of diamine oxidase and increased the plasma histamine concentration. Aminoguanidine attenuated the increase in mucosal apoptosis following reperfusion. Apoptosis induced by an ischemic insult to the intestinal mucosa was not related to an undesirable effect of histamine. Attenuation of increased intestinal apoptosis might be due to increased plasma histamine level and/or other pharmacological action of amioguanidine, including inhibition of inducible nitric oxide synthase.

KW - Aminoguanidine

KW - Diamine oxidase

KW - Fragmented DNA

KW - H-receptor antagonist

KW - H-receptor antagonist

KW - Nitric oxide

UR - http://www.scopus.com/inward/record.url?scp=0034048558&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034048558&partnerID=8YFLogxK

U2 - 10.1023/A:1005545801714

DO - 10.1023/A:1005545801714

M3 - Article

VL - 45

SP - 1138

EP - 1144

JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

IS - 6

ER -