TY - JOUR
T1 - Histogenesis of alveolar soft part sarcoma. An immunohistochemical and biochemical study
AU - Mukai, M.
AU - Torikata, C.
AU - Iri, H.
AU - Mikata, A.
AU - Hanaoka, H.
AU - Kato, K.
AU - Kageyama, K.
PY - 1986
Y1 - 1986
N2 - In order to clarify the histogenesis of alveolar soft part sarcoma (ASPS), an immunohistochemical and biochemical study was performed on three cases. The immunohistochemical study indicated the presence of actin, desmin, vimentin, and Z-protein in all cases. On the other hand, intermediate filaments other than desmin and vimentin were not detected immunohistochemically. The presence of desmin and Z-protein strongly suggests the myogenic character of this tumor. As to whether ASPS shows striated muscle differentiation or smooth muscle differentiation, the immunohistochemical absence of myoglobin in the three cases suggests that the tumor does not differentiate in the direction of striated muscle. However, biochemical assay of subunits of enolase revealed significantly high amounts of β-enolase, which is known as a marker for striated muscle, in all three cases. The determined values - 735, 426, and 584 ng/mg of protein - are indicative of striated muscle differentiation. In addition, the immunohistochemical study of all cases revealed the presence of β-enolase in tumor cells. These data definitely show the myogenic character and rhabdomyoblastic differentiation of ASPS.
AB - In order to clarify the histogenesis of alveolar soft part sarcoma (ASPS), an immunohistochemical and biochemical study was performed on three cases. The immunohistochemical study indicated the presence of actin, desmin, vimentin, and Z-protein in all cases. On the other hand, intermediate filaments other than desmin and vimentin were not detected immunohistochemically. The presence of desmin and Z-protein strongly suggests the myogenic character of this tumor. As to whether ASPS shows striated muscle differentiation or smooth muscle differentiation, the immunohistochemical absence of myoglobin in the three cases suggests that the tumor does not differentiate in the direction of striated muscle. However, biochemical assay of subunits of enolase revealed significantly high amounts of β-enolase, which is known as a marker for striated muscle, in all three cases. The determined values - 735, 426, and 584 ng/mg of protein - are indicative of striated muscle differentiation. In addition, the immunohistochemical study of all cases revealed the presence of β-enolase in tumor cells. These data definitely show the myogenic character and rhabdomyoblastic differentiation of ASPS.
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U2 - 10.1097/00000478-198603000-00008
DO - 10.1097/00000478-198603000-00008
M3 - Article
C2 - 3513637
AN - SCOPUS:0022490259
VL - 10
SP - 212
EP - 218
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
SN - 0147-5185
IS - 3
ER -