Histogenesis of clear cell sarcoma of tendons and aponeuroses. An electron-microscopic, biochemical, enzyme histochemical, and immunohistochemical study

M. Mukai, C. Torikata, H. Iri, A. Mikata, T. Kawai, Hironari Hanaoka, K. Yakumaru, K. Kageyama

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

For the purpose of clarifying the histogenesis of clear cell sarcoma of tendons and aponeuroses (CCS) as well as the problem of whether or not CCS is a heterogeneous group of neoplasms, studies based on various methods were performed. Analysis of glycosaminoglycans gave the same results for amelanotic CCS and synovial sarcoma, and the DOPA reaction gave the same negative results for amelanotic CCS and synovial sarcoma. However, the DOPA reaction was also negative in an amelanotic recurrent tumor of a melanotic CCS, and electron-microscopic studies revealed a close resemblance between amelanotic CCS and melanotic CCS. Further, enzyme histochemical studies showed definite differences between synovial sarcoma and amelanotic CCS but gave identical results for amelanotic and melanotic CCS. Immunohistochemical studies revealed the presence of S-100 protein in all CCS cases, both amelanotic and melanotic. These results indicate that CCS is not a heterogeneous group of neoplasms, and that both amelanotic and melanotic CCS are of neural crest origin.

Original languageEnglish
Pages (from-to)264-272
Number of pages9
JournalAmerican Journal of Pathology
Volume114
Issue number2
Publication statusPublished - 1984 Apr 5
Externally publishedYes

Fingerprint

Clear Cell Sarcoma
Synovial Sarcoma
Tendons
Electrons
Enzymes
Neoplasms
S100 Proteins
Neural Crest
Glycosaminoglycans
Aponeurosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Histogenesis of clear cell sarcoma of tendons and aponeuroses. An electron-microscopic, biochemical, enzyme histochemical, and immunohistochemical study. / Mukai, M.; Torikata, C.; Iri, H.; Mikata, A.; Kawai, T.; Hanaoka, Hironari; Yakumaru, K.; Kageyama, K.

In: American Journal of Pathology, Vol. 114, No. 2, 05.04.1984, p. 264-272.

Research output: Contribution to journalArticle

Mukai, M. ; Torikata, C. ; Iri, H. ; Mikata, A. ; Kawai, T. ; Hanaoka, Hironari ; Yakumaru, K. ; Kageyama, K. / Histogenesis of clear cell sarcoma of tendons and aponeuroses. An electron-microscopic, biochemical, enzyme histochemical, and immunohistochemical study. In: American Journal of Pathology. 1984 ; Vol. 114, No. 2. pp. 264-272.
@article{cb09bb8bdd5945bdb097bec3ed6970bd,
title = "Histogenesis of clear cell sarcoma of tendons and aponeuroses. An electron-microscopic, biochemical, enzyme histochemical, and immunohistochemical study",
abstract = "For the purpose of clarifying the histogenesis of clear cell sarcoma of tendons and aponeuroses (CCS) as well as the problem of whether or not CCS is a heterogeneous group of neoplasms, studies based on various methods were performed. Analysis of glycosaminoglycans gave the same results for amelanotic CCS and synovial sarcoma, and the DOPA reaction gave the same negative results for amelanotic CCS and synovial sarcoma. However, the DOPA reaction was also negative in an amelanotic recurrent tumor of a melanotic CCS, and electron-microscopic studies revealed a close resemblance between amelanotic CCS and melanotic CCS. Further, enzyme histochemical studies showed definite differences between synovial sarcoma and amelanotic CCS but gave identical results for amelanotic and melanotic CCS. Immunohistochemical studies revealed the presence of S-100 protein in all CCS cases, both amelanotic and melanotic. These results indicate that CCS is not a heterogeneous group of neoplasms, and that both amelanotic and melanotic CCS are of neural crest origin.",
author = "M. Mukai and C. Torikata and H. Iri and A. Mikata and T. Kawai and Hironari Hanaoka and K. Yakumaru and K. Kageyama",
year = "1984",
month = "4",
day = "5",
language = "English",
volume = "114",
pages = "264--272",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Histogenesis of clear cell sarcoma of tendons and aponeuroses. An electron-microscopic, biochemical, enzyme histochemical, and immunohistochemical study

AU - Mukai, M.

AU - Torikata, C.

AU - Iri, H.

AU - Mikata, A.

AU - Kawai, T.

AU - Hanaoka, Hironari

AU - Yakumaru, K.

AU - Kageyama, K.

PY - 1984/4/5

Y1 - 1984/4/5

N2 - For the purpose of clarifying the histogenesis of clear cell sarcoma of tendons and aponeuroses (CCS) as well as the problem of whether or not CCS is a heterogeneous group of neoplasms, studies based on various methods were performed. Analysis of glycosaminoglycans gave the same results for amelanotic CCS and synovial sarcoma, and the DOPA reaction gave the same negative results for amelanotic CCS and synovial sarcoma. However, the DOPA reaction was also negative in an amelanotic recurrent tumor of a melanotic CCS, and electron-microscopic studies revealed a close resemblance between amelanotic CCS and melanotic CCS. Further, enzyme histochemical studies showed definite differences between synovial sarcoma and amelanotic CCS but gave identical results for amelanotic and melanotic CCS. Immunohistochemical studies revealed the presence of S-100 protein in all CCS cases, both amelanotic and melanotic. These results indicate that CCS is not a heterogeneous group of neoplasms, and that both amelanotic and melanotic CCS are of neural crest origin.

AB - For the purpose of clarifying the histogenesis of clear cell sarcoma of tendons and aponeuroses (CCS) as well as the problem of whether or not CCS is a heterogeneous group of neoplasms, studies based on various methods were performed. Analysis of glycosaminoglycans gave the same results for amelanotic CCS and synovial sarcoma, and the DOPA reaction gave the same negative results for amelanotic CCS and synovial sarcoma. However, the DOPA reaction was also negative in an amelanotic recurrent tumor of a melanotic CCS, and electron-microscopic studies revealed a close resemblance between amelanotic CCS and melanotic CCS. Further, enzyme histochemical studies showed definite differences between synovial sarcoma and amelanotic CCS but gave identical results for amelanotic and melanotic CCS. Immunohistochemical studies revealed the presence of S-100 protein in all CCS cases, both amelanotic and melanotic. These results indicate that CCS is not a heterogeneous group of neoplasms, and that both amelanotic and melanotic CCS are of neural crest origin.

UR - http://www.scopus.com/inward/record.url?scp=0021358429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021358429&partnerID=8YFLogxK

M3 - Article

C2 - 6320649

AN - SCOPUS:0021358429

VL - 114

SP - 264

EP - 272

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 2

ER -