Histological evaluation of the effect of smoking on peripheral small adenocarcinomas of the lung

Akiko Miyagi Maeshima, Naobumi Tochigi, Koji Tsuta, Hisao Asamura, Yoshihiro Matsuno

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Introduction:: As there is little information on the histologic characteristics of adenocarcinoma in smokers, we histologically examined the effect of smoking on the carcinogenesis and progression of peripheral small lung adenocarcinomas. Methods:: Two hundred thirty-six consecutive patients with peripheral adenocarcinoma of the lung 30 mm or less in diameter were studied. Prognosis, histology, and location of the adenocarcinoma were compared among patients with a Brinkman index (B.I.) of 0, 1 to 500, and more than 500. Results:: The ratio of smokers to nonsmokers was 1.4:1. The rate of carcinogenesis in the upper region of the lung (S1-3) was 1.4 times as high that in the lower region (S4-10) in smokers, but almost equal in the two regions in nonsmokers. Outcome tended to be worse in patients with a B.I. of more than 500 than in those with a B.I. of less than or equal to 500 for adenocarcinomas 30 mm or less in diameter (p = 0.0855), and was significantly worse for adenocarcinomas 20 mm or less in diameter (p = 0.0359). Patients with a high B.I. tended to have invasive adenocarcinoma (IAC) without a bronchioloalveolar carcinoma (BAC) component (IAC- BAC) or IAC with a BAC component (IAC + BAC) rather than noninvasive adenocarcinoma. For adenocarcinomas as a whole, B.I. was correlated with several pathologic prognostic factors, including pathologic stage, lymphatic permeation, vascular invasion, presence of a solid component, necrosis, and modified scar grade, particularly in the upper region. Specifically, in IAC + BAC, B.I. was correlated with modified scar grade and the presence of a solid component. In IAC- BAC, B.I. was correlated with the presence of a solid component and necrosis. Conclusions:: Small adenocarcinoma in smokers seems to occur frequently in the upper region of the lung, shows invasive features more frequently, and shows greater progression and dedifferentiation than that in nonsmokers. Tobacco-smoking may have an effect on the carcinogenesis and multistep progression of peripheral lung adenocarcinoma 30 mm or less in diameter.

Original languageEnglish
Pages (from-to)698-703
Number of pages6
JournalJournal of Thoracic Oncology
Volume3
Issue number7
DOIs
Publication statusPublished - 2008 Jul
Externally publishedYes

Fingerprint

Adenocarcinoma
Smoking
Bronchiolo-Alveolar Adenocarcinoma
Carcinogenesis
Cicatrix
Adenocarcinoma of lung
Necrosis
Lung
Blood Vessels
Histology

Keywords

  • Adenocarcinoma
  • Histology
  • Lung
  • Smoking

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Histological evaluation of the effect of smoking on peripheral small adenocarcinomas of the lung. / Maeshima, Akiko Miyagi; Tochigi, Naobumi; Tsuta, Koji; Asamura, Hisao; Matsuno, Yoshihiro.

In: Journal of Thoracic Oncology, Vol. 3, No. 7, 07.2008, p. 698-703.

Research output: Contribution to journalArticle

Maeshima, Akiko Miyagi ; Tochigi, Naobumi ; Tsuta, Koji ; Asamura, Hisao ; Matsuno, Yoshihiro. / Histological evaluation of the effect of smoking on peripheral small adenocarcinomas of the lung. In: Journal of Thoracic Oncology. 2008 ; Vol. 3, No. 7. pp. 698-703.
@article{bb991f1288a4480380db02d2fef0cf99,
title = "Histological evaluation of the effect of smoking on peripheral small adenocarcinomas of the lung",
abstract = "Introduction:: As there is little information on the histologic characteristics of adenocarcinoma in smokers, we histologically examined the effect of smoking on the carcinogenesis and progression of peripheral small lung adenocarcinomas. Methods:: Two hundred thirty-six consecutive patients with peripheral adenocarcinoma of the lung 30 mm or less in diameter were studied. Prognosis, histology, and location of the adenocarcinoma were compared among patients with a Brinkman index (B.I.) of 0, 1 to 500, and more than 500. Results:: The ratio of smokers to nonsmokers was 1.4:1. The rate of carcinogenesis in the upper region of the lung (S1-3) was 1.4 times as high that in the lower region (S4-10) in smokers, but almost equal in the two regions in nonsmokers. Outcome tended to be worse in patients with a B.I. of more than 500 than in those with a B.I. of less than or equal to 500 for adenocarcinomas 30 mm or less in diameter (p = 0.0855), and was significantly worse for adenocarcinomas 20 mm or less in diameter (p = 0.0359). Patients with a high B.I. tended to have invasive adenocarcinoma (IAC) without a bronchioloalveolar carcinoma (BAC) component (IAC- BAC) or IAC with a BAC component (IAC + BAC) rather than noninvasive adenocarcinoma. For adenocarcinomas as a whole, B.I. was correlated with several pathologic prognostic factors, including pathologic stage, lymphatic permeation, vascular invasion, presence of a solid component, necrosis, and modified scar grade, particularly in the upper region. Specifically, in IAC + BAC, B.I. was correlated with modified scar grade and the presence of a solid component. In IAC- BAC, B.I. was correlated with the presence of a solid component and necrosis. Conclusions:: Small adenocarcinoma in smokers seems to occur frequently in the upper region of the lung, shows invasive features more frequently, and shows greater progression and dedifferentiation than that in nonsmokers. Tobacco-smoking may have an effect on the carcinogenesis and multistep progression of peripheral lung adenocarcinoma 30 mm or less in diameter.",
keywords = "Adenocarcinoma, Histology, Lung, Smoking",
author = "Maeshima, {Akiko Miyagi} and Naobumi Tochigi and Koji Tsuta and Hisao Asamura and Yoshihiro Matsuno",
year = "2008",
month = "7",
doi = "10.1097/JTO.0b013e31817c60ae",
language = "English",
volume = "3",
pages = "698--703",
journal = "Journal of Thoracic Oncology",
issn = "1556-0864",
publisher = "International Association for the Study of Lung Cancer",
number = "7",

}

TY - JOUR

T1 - Histological evaluation of the effect of smoking on peripheral small adenocarcinomas of the lung

AU - Maeshima, Akiko Miyagi

AU - Tochigi, Naobumi

AU - Tsuta, Koji

AU - Asamura, Hisao

AU - Matsuno, Yoshihiro

PY - 2008/7

Y1 - 2008/7

N2 - Introduction:: As there is little information on the histologic characteristics of adenocarcinoma in smokers, we histologically examined the effect of smoking on the carcinogenesis and progression of peripheral small lung adenocarcinomas. Methods:: Two hundred thirty-six consecutive patients with peripheral adenocarcinoma of the lung 30 mm or less in diameter were studied. Prognosis, histology, and location of the adenocarcinoma were compared among patients with a Brinkman index (B.I.) of 0, 1 to 500, and more than 500. Results:: The ratio of smokers to nonsmokers was 1.4:1. The rate of carcinogenesis in the upper region of the lung (S1-3) was 1.4 times as high that in the lower region (S4-10) in smokers, but almost equal in the two regions in nonsmokers. Outcome tended to be worse in patients with a B.I. of more than 500 than in those with a B.I. of less than or equal to 500 for adenocarcinomas 30 mm or less in diameter (p = 0.0855), and was significantly worse for adenocarcinomas 20 mm or less in diameter (p = 0.0359). Patients with a high B.I. tended to have invasive adenocarcinoma (IAC) without a bronchioloalveolar carcinoma (BAC) component (IAC- BAC) or IAC with a BAC component (IAC + BAC) rather than noninvasive adenocarcinoma. For adenocarcinomas as a whole, B.I. was correlated with several pathologic prognostic factors, including pathologic stage, lymphatic permeation, vascular invasion, presence of a solid component, necrosis, and modified scar grade, particularly in the upper region. Specifically, in IAC + BAC, B.I. was correlated with modified scar grade and the presence of a solid component. In IAC- BAC, B.I. was correlated with the presence of a solid component and necrosis. Conclusions:: Small adenocarcinoma in smokers seems to occur frequently in the upper region of the lung, shows invasive features more frequently, and shows greater progression and dedifferentiation than that in nonsmokers. Tobacco-smoking may have an effect on the carcinogenesis and multistep progression of peripheral lung adenocarcinoma 30 mm or less in diameter.

AB - Introduction:: As there is little information on the histologic characteristics of adenocarcinoma in smokers, we histologically examined the effect of smoking on the carcinogenesis and progression of peripheral small lung adenocarcinomas. Methods:: Two hundred thirty-six consecutive patients with peripheral adenocarcinoma of the lung 30 mm or less in diameter were studied. Prognosis, histology, and location of the adenocarcinoma were compared among patients with a Brinkman index (B.I.) of 0, 1 to 500, and more than 500. Results:: The ratio of smokers to nonsmokers was 1.4:1. The rate of carcinogenesis in the upper region of the lung (S1-3) was 1.4 times as high that in the lower region (S4-10) in smokers, but almost equal in the two regions in nonsmokers. Outcome tended to be worse in patients with a B.I. of more than 500 than in those with a B.I. of less than or equal to 500 for adenocarcinomas 30 mm or less in diameter (p = 0.0855), and was significantly worse for adenocarcinomas 20 mm or less in diameter (p = 0.0359). Patients with a high B.I. tended to have invasive adenocarcinoma (IAC) without a bronchioloalveolar carcinoma (BAC) component (IAC- BAC) or IAC with a BAC component (IAC + BAC) rather than noninvasive adenocarcinoma. For adenocarcinomas as a whole, B.I. was correlated with several pathologic prognostic factors, including pathologic stage, lymphatic permeation, vascular invasion, presence of a solid component, necrosis, and modified scar grade, particularly in the upper region. Specifically, in IAC + BAC, B.I. was correlated with modified scar grade and the presence of a solid component. In IAC- BAC, B.I. was correlated with the presence of a solid component and necrosis. Conclusions:: Small adenocarcinoma in smokers seems to occur frequently in the upper region of the lung, shows invasive features more frequently, and shows greater progression and dedifferentiation than that in nonsmokers. Tobacco-smoking may have an effect on the carcinogenesis and multistep progression of peripheral lung adenocarcinoma 30 mm or less in diameter.

KW - Adenocarcinoma

KW - Histology

KW - Lung

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=50349102871&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50349102871&partnerID=8YFLogxK

U2 - 10.1097/JTO.0b013e31817c60ae

DO - 10.1097/JTO.0b013e31817c60ae

M3 - Article

C2 - 18594313

AN - SCOPUS:50349102871

VL - 3

SP - 698

EP - 703

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

SN - 1556-0864

IS - 7

ER -