Histology is a Prognostic Indicator After Pulmonary Metastasectomy from Renal Cell Carcinoma

Yoichi Ohtaki, Kimihiro Shimizu, Keiju Aokage, Masayuki Nakao, Junji Yoshida, Mitsuhiro Kamiyoshihara, Masayuki Sugano, Yusuke Takahashi, Seshiru Nakazawa, Toshiteru Nagashima, Kai Obayashi, Tomoyuki Hishida, Masahiro Tsuboi, Shohei Mori, Mingyon Mun, Sakae Okumura, Hitoshi Igai, Noriyuki Matsutani, Akira Mogi, Hiroyuki Kuwano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: There are only a few detailed reports concerning the prognosticators following surgical resection of pulmonary metastases (PMs) from renal cell carcinoma (RCC). We investigated the prognosis of patients with RCC PMs undergoing pulmonary metastasectomy and identified prognostic factors in a multi-institutional retrospective study. Methods: We retrospectively evaluated 84 patients who underwent resection of PMs from RCC between 1993 and 2014. We assessed the clinicopathological characteristics, focusing on the histological findings of PMs. We classified the histology into three types: pure clear cell carcinoma (N = 68), clear cell carcinoma combined with other histology type (N = 8), and non-clear cell carcinoma (N = 8). We examined the relationship between these histological types and the prognosis of patients with PMs from RCC. Results: Complete resection was achieved in 78 patients (93%). The 5-year overall survival rate after metastasectomy was 59.7%. In multivariate analysis, three factors were found to be independent favorable prognostic factors of overall survival after lung metastasectomy [tumor size <2 cm, hazard ratio (HR) = 0.31, 95% confidence interval (CI) 0.13–0.78, P = 0.012; clear cell type, HR = 0.37, 95% CI 0.16–0.83, P = 0.025; and complete resection, HR = 0.27, 95% CI 0.10–0.78, P = 0.015]. Conclusions: This study indicates that a histological finding of the clear cell type is a significant favorable prognostic factor in addition to complete resection and a tumor size <2 cm. Histological evaluation of PM lesions is important for predicting survival after metastasectomy.

Original languageEnglish
Pages (from-to)771-779
Number of pages9
JournalWorld Journal of Surgery
Volume41
Issue number3
DOIs
Publication statusPublished - 2017 Mar 1
Externally publishedYes

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Metastasectomy
Renal Cell Carcinoma
Histology
Lung
Neoplasm Metastasis
Confidence Intervals
Carcinoma
Survival
Neoplasms
Multivariate Analysis
Survival Rate
Retrospective Studies

ASJC Scopus subject areas

  • Surgery

Cite this

Ohtaki, Y., Shimizu, K., Aokage, K., Nakao, M., Yoshida, J., Kamiyoshihara, M., ... Kuwano, H. (2017). Histology is a Prognostic Indicator After Pulmonary Metastasectomy from Renal Cell Carcinoma. World Journal of Surgery, 41(3), 771-779. https://doi.org/10.1007/s00268-016-3802-9

Histology is a Prognostic Indicator After Pulmonary Metastasectomy from Renal Cell Carcinoma. / Ohtaki, Yoichi; Shimizu, Kimihiro; Aokage, Keiju; Nakao, Masayuki; Yoshida, Junji; Kamiyoshihara, Mitsuhiro; Sugano, Masayuki; Takahashi, Yusuke; Nakazawa, Seshiru; Nagashima, Toshiteru; Obayashi, Kai; Hishida, Tomoyuki; Tsuboi, Masahiro; Mori, Shohei; Mun, Mingyon; Okumura, Sakae; Igai, Hitoshi; Matsutani, Noriyuki; Mogi, Akira; Kuwano, Hiroyuki.

In: World Journal of Surgery, Vol. 41, No. 3, 01.03.2017, p. 771-779.

Research output: Contribution to journalArticle

Ohtaki, Y, Shimizu, K, Aokage, K, Nakao, M, Yoshida, J, Kamiyoshihara, M, Sugano, M, Takahashi, Y, Nakazawa, S, Nagashima, T, Obayashi, K, Hishida, T, Tsuboi, M, Mori, S, Mun, M, Okumura, S, Igai, H, Matsutani, N, Mogi, A & Kuwano, H 2017, 'Histology is a Prognostic Indicator After Pulmonary Metastasectomy from Renal Cell Carcinoma', World Journal of Surgery, vol. 41, no. 3, pp. 771-779. https://doi.org/10.1007/s00268-016-3802-9
Ohtaki, Yoichi ; Shimizu, Kimihiro ; Aokage, Keiju ; Nakao, Masayuki ; Yoshida, Junji ; Kamiyoshihara, Mitsuhiro ; Sugano, Masayuki ; Takahashi, Yusuke ; Nakazawa, Seshiru ; Nagashima, Toshiteru ; Obayashi, Kai ; Hishida, Tomoyuki ; Tsuboi, Masahiro ; Mori, Shohei ; Mun, Mingyon ; Okumura, Sakae ; Igai, Hitoshi ; Matsutani, Noriyuki ; Mogi, Akira ; Kuwano, Hiroyuki. / Histology is a Prognostic Indicator After Pulmonary Metastasectomy from Renal Cell Carcinoma. In: World Journal of Surgery. 2017 ; Vol. 41, No. 3. pp. 771-779.
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abstract = "Objectives: There are only a few detailed reports concerning the prognosticators following surgical resection of pulmonary metastases (PMs) from renal cell carcinoma (RCC). We investigated the prognosis of patients with RCC PMs undergoing pulmonary metastasectomy and identified prognostic factors in a multi-institutional retrospective study. Methods: We retrospectively evaluated 84 patients who underwent resection of PMs from RCC between 1993 and 2014. We assessed the clinicopathological characteristics, focusing on the histological findings of PMs. We classified the histology into three types: pure clear cell carcinoma (N = 68), clear cell carcinoma combined with other histology type (N = 8), and non-clear cell carcinoma (N = 8). We examined the relationship between these histological types and the prognosis of patients with PMs from RCC. Results: Complete resection was achieved in 78 patients (93{\%}). The 5-year overall survival rate after metastasectomy was 59.7{\%}. In multivariate analysis, three factors were found to be independent favorable prognostic factors of overall survival after lung metastasectomy [tumor size <2 cm, hazard ratio (HR) = 0.31, 95{\%} confidence interval (CI) 0.13–0.78, P = 0.012; clear cell type, HR = 0.37, 95{\%} CI 0.16–0.83, P = 0.025; and complete resection, HR = 0.27, 95{\%} CI 0.10–0.78, P = 0.015]. Conclusions: This study indicates that a histological finding of the clear cell type is a significant favorable prognostic factor in addition to complete resection and a tumor size <2 cm. Histological evaluation of PM lesions is important for predicting survival after metastasectomy.",
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AU - Ohtaki, Yoichi

AU - Shimizu, Kimihiro

AU - Aokage, Keiju

AU - Nakao, Masayuki

AU - Yoshida, Junji

AU - Kamiyoshihara, Mitsuhiro

AU - Sugano, Masayuki

AU - Takahashi, Yusuke

AU - Nakazawa, Seshiru

AU - Nagashima, Toshiteru

AU - Obayashi, Kai

AU - Hishida, Tomoyuki

AU - Tsuboi, Masahiro

AU - Mori, Shohei

AU - Mun, Mingyon

AU - Okumura, Sakae

AU - Igai, Hitoshi

AU - Matsutani, Noriyuki

AU - Mogi, Akira

AU - Kuwano, Hiroyuki

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N2 - Objectives: There are only a few detailed reports concerning the prognosticators following surgical resection of pulmonary metastases (PMs) from renal cell carcinoma (RCC). We investigated the prognosis of patients with RCC PMs undergoing pulmonary metastasectomy and identified prognostic factors in a multi-institutional retrospective study. Methods: We retrospectively evaluated 84 patients who underwent resection of PMs from RCC between 1993 and 2014. We assessed the clinicopathological characteristics, focusing on the histological findings of PMs. We classified the histology into three types: pure clear cell carcinoma (N = 68), clear cell carcinoma combined with other histology type (N = 8), and non-clear cell carcinoma (N = 8). We examined the relationship between these histological types and the prognosis of patients with PMs from RCC. Results: Complete resection was achieved in 78 patients (93%). The 5-year overall survival rate after metastasectomy was 59.7%. In multivariate analysis, three factors were found to be independent favorable prognostic factors of overall survival after lung metastasectomy [tumor size <2 cm, hazard ratio (HR) = 0.31, 95% confidence interval (CI) 0.13–0.78, P = 0.012; clear cell type, HR = 0.37, 95% CI 0.16–0.83, P = 0.025; and complete resection, HR = 0.27, 95% CI 0.10–0.78, P = 0.015]. Conclusions: This study indicates that a histological finding of the clear cell type is a significant favorable prognostic factor in addition to complete resection and a tumor size <2 cm. Histological evaluation of PM lesions is important for predicting survival after metastasectomy.

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